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Eugene Khandros, MD, PhD
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Assistant Professor of Pediatrics (Hematology)
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Department: Pediatrics
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Graduate Group Affiliations
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Contact information
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Children's Hospital of Philadelphia
26 Abramson Research Center, 316A
39 3615 Civic Center Blvd
Philadelphia, PA 19104
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26 Abramson Research Center, 316A
39 3615 Civic Center Blvd
Philadelphia, PA 19104
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Lab: (215) 590-4461
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Email:
khandrose@chop.edu
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khandrose@chop.edu
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Publications
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Education:
21 7 BA 19 (Biochemistry) c
2c Columbia University, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
46 University of Pennsylvania School of Medicine, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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21 7 BA 19 (Biochemistry) c
2c Columbia University, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
46 University of Pennsylvania School of Medicine, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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Links
b9 Search PubMed for articles
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Permanent linkb9 Search PubMed for articles
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1b Sickle cell disease
12 Thalassemia
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18 Fetal hemoglobin
1f Red blood cell disorders
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Description of Clinical Expertise
25 Pediatric hematology1b Sickle cell disease
12 Thalassemia
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Description of Research Expertise
23 Hemoglobinopathies18 Fetal hemoglobin
1f Red blood cell disorders
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ca Khandros E, Steinberg MH: One cell at a time: HbF distribution in sickle cell disease. Blood Advances 10(4): 1278-1280, Feb 2026.
184 Traxler EA, Hotan Q, Shao Y, Komar C, Chen Q, Saari MS, Thrasher AJ, Yang S, Qin K, Wang M, Peslak SA, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Minn AJ, Khandros E, Shi J, Blobel GA: Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing. Blood Jan 2026.
187 Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS: Outcomes of Unrelated Donor Stem Cell Transplantation with Partial T Cell Depletion for Pediatric Patients with Hemoglobinopathies. Transplant Cell Ther 31(10): 828, July 2025.
142 Gibson NM, Khandros E, Elgarten CW, Worster E, Monos DS, Thompson AA, Kwiatkowski JL, Olson T: Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia. Blood 145(22): 2666-2670, May 2025.
14f Lechauve C, Keith J, Fernandez AG, Khandros E, Mayberry K, Mayuranathan T, Palmer LE, Qiu X, Sheppard H, Telange R, Herz HM, Weiss MJ: Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model. Blood Advances 8(23): 5988-5992, Dec 2024.
cc Khandros E, Blobel GA: Elevating fetal hemoglobin - recently discovered regulators and mechanisms. Blood 144(8): 845-852, Aug 2024.
121 Huang P, Peslak SA, Shehu V, Keller CA, Giardine BM, Shi J, Hardison RC, Blobel GA, Khandros E: Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood 143(19): 1980-1991, May 2024.
91 Khandros E, Kwiatkowski JL: Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin 92 Chain Synthesis. Wintrobe's Clinical Hematology, 15th edition. Means, RT (eds.). Wolters Kluwer, Page: 883-932, July 2023.
12e Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood 141(22): 2756-2770, Jun 2023.
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Selected Publications
18a Bagchi A, Billakanti S, Shehu V, Farrell KM, Cotteta SA, Godfrey BN, Alpert M, Flores Zeranski J, Budinich KA, Geng Z, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Shi J, Khandros E: Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex. Blood 147(6): 675-688, Feb 2026.ca Khandros E, Steinberg MH: One cell at a time: HbF distribution in sickle cell disease. Blood Advances 10(4): 1278-1280, Feb 2026.
184 Traxler EA, Hotan Q, Shao Y, Komar C, Chen Q, Saari MS, Thrasher AJ, Yang S, Qin K, Wang M, Peslak SA, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Minn AJ, Khandros E, Shi J, Blobel GA: Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing. Blood Jan 2026.
187 Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS: Outcomes of Unrelated Donor Stem Cell Transplantation with Partial T Cell Depletion for Pediatric Patients with Hemoglobinopathies. Transplant Cell Ther 31(10): 828, July 2025.
142 Gibson NM, Khandros E, Elgarten CW, Worster E, Monos DS, Thompson AA, Kwiatkowski JL, Olson T: Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia. Blood 145(22): 2666-2670, May 2025.
14f Lechauve C, Keith J, Fernandez AG, Khandros E, Mayberry K, Mayuranathan T, Palmer LE, Qiu X, Sheppard H, Telange R, Herz HM, Weiss MJ: Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model. Blood Advances 8(23): 5988-5992, Dec 2024.
cc Khandros E, Blobel GA: Elevating fetal hemoglobin - recently discovered regulators and mechanisms. Blood 144(8): 845-852, Aug 2024.
121 Huang P, Peslak SA, Shehu V, Keller CA, Giardine BM, Shi J, Hardison RC, Blobel GA, Khandros E: Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood 143(19): 1980-1991, May 2024.
91 Khandros E, Kwiatkowski JL: Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin 92 Chain Synthesis. Wintrobe's Clinical Hematology, 15th edition. Means, RT (eds.). Wolters Kluwer, Page: 883-932, July 2023.
12e Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood 141(22): 2756-2770, Jun 2023.
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