Faculty

Eric F. Joyce, Ph.D.

faculty photo
Associate Professor of Genetics
Department: Genetics

Contact information
564 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
Education:
B.A. (Genetics and Microbiology)
Rutgers University, 2004.
Ph.D. (Microbiology and Molecular Genetics)
Rutgers University, 2010.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.

Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization

Rotation Projects: Please contact Eric for more details.

Selected Publications

Park DS, Nguyen SC, Isenhart R, Shah PP, Kim W, Barnett RJ, Chandra A, Luppino JM, Harke J, Wai M, Walsh PJ, Abdill RJ, Yang R, Lan Y, Yoon S, Yunker R, Kanemaki MT, Vahedi G, Phillips-Cremins JE, Jain R, Joyce EF.: High-throughput Oligopaint screen identifies druggable 3D genome regulators. Nature 620(7972): 209-217, Aug 2023.

Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Abdill RJ, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF.: Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression. PLoS Genet 18: e1010528, Nov 2022.

Luan J, Vermunt MW, Syrett CM, Coté A, Tome JM, Zhang H, Huang A, Luppino JM, Keller CA, Giardine BM, Zhang S, Dunagin MC, Zhang Z, Joyce EF, Lis JT, Raj A, Hardison RC, Blobel GA.: CTCF blocks antisense transcription initiation at divergent promoters. Nat Struct Mol Biol 29(11): 1136-1144, Nov 2022 Notes: This was a collaboration in which my lab contributed the nascent expression data for human cells depleted of CTCF.

Wang W, Chandra A, Goldman N, Yoon S, Ferrari EK, Nguyen SC, Joyce EF, Vahedi G.: TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nat Immunol 23(7): 1052-1062, Jun 2022 Notes: This was a collaboration in which my lab contributed the design and generation of custom Oligopaint probes and imaging support.

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R.: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet 53(1): 1480-1492, Oct 2021 Notes: This was a collaboration in which my lab contributed the design and generation of custom Oligopaint probes and imaging support.

Luppino, J. M., Park, D. S., Nguyen, S. C., Lan, Y., Xu, Z., Yunker, R., Joyce, E. F.: Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. Nat Genet 52(8): 840-848, Aug 2020.

Luppino Jennifer M, Joyce Eric F: Single cell analysis pushes the boundaries of TAD formation and function. Current opinion in genetics & development 61: 25-31, Apr 2020.

Ren Wenqing, Medeiros Nicole, Warneford-Thomson Robert, Wulfridge Phillip, Yan Qingqing, Bian Joyce, Sidoli Simone, Garcia Benjamin A, Skordalakes Emmanuel, Joyce Eric, Bonasio Roberto, Sarma Kavitha: Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Nature communications 11(1): 2219, May 2020.

Gozalo Alejandro, Duke Ashley, Lan Yemin, Pascual-Garcia Pau, Talamas Jessica A, Nguyen Son C, Shah Parisha P, Jain Rajan, Joyce Eric F, Capelson Maya: Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Molecular cell 77(1): 67-81, Jan 2020.

Rosin Leah F, Crocker Olivia, Isenhart Randi L, Nguyen Son C, Xu Zhuxuan, Joyce Eric F: Chromosome territory formation attenuates the translocation potential of cells. eLife 8, Nov 2019.

back to top
Last updated: 02/22/2024
The Trustees of the University of Pennsylvania