Faculty

Eric F. Joyce, Ph.D.

Associate Professor of Genetics

Department: Genetics

Graduate Group Affiliations

Contact information

564 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145

Email:
erjoyce@upenn.edu

Education:
B.A. (Genetics and Microbiology)
Rutgers University, 2004.
Ph.D. (Microbiology and Molecular Genetics)
Rutgers University, 2010.

Links
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.

Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization

Rotation Projects: Please contact Eric for more details.

Selected Publications

Harke J, Lee JR, Nguyen SC, Arab A, Rakowiecki SM, Hugelier S, Paliou C, Rauseo A, Yunker R, Xu K, Yao Y, Lakadamyali M, Andrey G, Epstein DJ, Joyce EF.: Multiple allelic configurations govern long-range Shh enhancer-promoter communication in the embryonic forebrain. Mol Cell Nov 2024.

Mokhtaridoost M, Chalmers JJ, Soleimanpoor M, McMurray BJ, Lato DF, Nguyen SC, Musienko V, Nash JO, Espeso-Gil S, Ahmed S, Delfosse K, Browning JWL, Barutcu AR, Wilson MD, Liehr T, Shlien A, Aref S, Joyce EF, Weise A, Maass PG.: Inter-chromosomal contacts demarcate genome topology along a spatial gradient. Nat Commun 15: 9813, Nov 2024.

Chavan A, Isenhart R, Nguyen SC, Kotb NM, Harke J, Sintsova A, Ulukaya G, Uliana F, Ashiono C, Kutay U, Pegoraro G, Rangan P, Joyce EF, Jagannathan M.: A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate. Genes Dev 38: 415-435, Jun 2024.

Park DS, Nguyen SC, Isenhart R, Shah PP, Kim W, Barnett RJ, Chandra A, Luppino JM, Harke J, Wai M, Walsh PJ, Abdill RJ, Yang R, Lan Y, Yoon S, Yunker R, Kanemaki MT, Vahedi G, Phillips-Cremins JE, Jain R, Joyce EF.: High-throughput Oligopaint screen identifies druggable 3D genome regulators. Nature 620(7972): 209-217, Aug 2023.

Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Abdill RJ, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF.: Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression. PLoS Genet 18: e1010528, Nov 2022.

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R.: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet 53(1): 1480-1492, Oct 2021 Notes: This was a collaboration in which my lab contributed the design and generation of custom Oligopaint probes and imaging support.

Luppino, J. M., Park, D. S., Nguyen, S. C., Lan, Y., Xu, Z., Yunker, R., Joyce, E. F.: Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. Nat Genet 52(8): 840-848, Aug 2020.

Luppino Jennifer M, Joyce Eric F: Single cell analysis pushes the boundaries of TAD formation and function. Current opinion in genetics & development 61: 25-31, Apr 2020.

Rosin Leah F, Crocker Olivia, Isenhart Randi L, Nguyen Son C, Xu Zhuxuan, Joyce Eric F: Chromosome territory formation attenuates the translocation potential of cells. eLife 8, Nov 2019.