Faculty
Glen N. Gaulton, Ph.D.
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
University of Pennsylvania
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Office: (215) 898-0848
Fax: (215) 573-7945
Fax: (215) 573-7945
Publications
Education:
B.S. (Biology, with honors)
University of California, Santa Barbara, 1974.
Ph.D. (Biochemistry/Molecular Biology)
University of California, Santa Barbara, 1981.
B.S. (Biology, with honors)
University of California, Santa Barbara, 1974.
Ph.D. (Biochemistry/Molecular Biology)
University of California, Santa Barbara, 1981.
Links
Search PubMed for articles
Immunology graduate group faculty webpage.
Cell and Molecular Biology graduate group faculty webpage.
Permanent linkSearch PubMed for articles
Immunology graduate group faculty webpage.
Cell and Molecular Biology graduate group faculty webpage.
Description of Research Expertise
Research InterestGlobal Health, Education Program Building, Lymphocyte development and retroviral pathology
Keywords: Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics
Research Techniques:
Molecular genetics, cell biology, imaging, diagnostics, virology, immunology
Research Summary
The interests of the Gaulton laboratory focus on an increased understanding of the molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches.
More specifically, the laboratory has investigated the effects of human and, as experimental models, murine retroviruses during active infection of adult, pediatric and neonatal subjects. Recent results have identified the primary mechanisms whereby retroviruses induce cell destruction through cell-cell fusion, also know as syncytia formation. The laboratory has pioneered the use of magnetic resonance imaging (MRI) techniques to detect HIV infection within cells and is now applying these techniques to in vivo, whole body imaging of active infections. Lastly, using state-of-the-art engineering technology, the laboratory is developing highly sensitive yet mobile, hand-held devices to detect HIV infection in blood. These devices are critical for diagnosing new infections, and to monitor HIV levels in patients undergoing active therapy and/or participating in vaccine trials.
Other functions of Dr. Gaulton relate to the planning and oversight of Penn Medicine's world-wide global health programs.
Lab personnel:
Tomasz Rosmyslowicz,M.D., Sr. Research Investigator
Selected Publications
Lin, G, Murphy, SL, Gaulton, GN, and Hoxie, JA: Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase. Journal of Virology Methods 128(1-2): 135-142, Sep 2005.Levinson, Al, Song, D, Gaulton, GN, and Zheng: The intrathymic pathogenesis of myasthenia gravis. Clinical Development Immunology 11: 215-220, 2005.
Murphy, SL, Honczarenko, MJ, Dugger, NV, Hoffman, PM, Gaulton, GN: Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. Journal of Virology 78: 8392 - 8399, 2004.
Chung Landers, M., Dugger, N., Quadros, M., Hoffman, P. M., and Gaulton, G.N.: Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of primary BALB/c brain capillary endothelium. Virology 321: 57-64, 2004.
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