Faculty

Yi-Wei Chang, Ph.D.

Assistant Professor of Biochemistry and Biophysics

Department: Biochemistry and Biophysics

Graduate Group Affiliations

Contact information

Department of Biochemistry and Biophysics
Perelman School of Medicine
University of Pennsylvania
913B Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6059

Office: (215) 898-7789
Lab: (215) 898-1191

Email:
ywc@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
B.S. (Mechanical Engineering )
Chung Hua University, Taiwan, 2004.
Ph.D. (Structural Biology )
Academia Sinica & National Tsing Hua University, Taiwan, 2010.
Cert. (Research Mentor Training: Effective Communication and Aligning Expectations)
Perelman School of Medicine, University of Pennsylvania, 2022.

Links
Search PubMed for articles
- 2019 Packard Fellowships in Science and Engineering, The David and Lucile Packard Foundation
- 2022 FIB-Milling Sample Preparation for Cellular CryoET Award, The Arnold and Mabel Beckman Foundation
- Google Scholar Citations
- 2019 ASPIRE Award, The Mark Foundation for Cancer Research
- 2022 Catalysts Fellow, The EMBO Journal
- 2023 Investigators in the Pathogenesis of Infectious Disease, The Burroughs Wellcome Fund
- Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Structural biology;
Cryo-electron microscopy;
Cryo-electron tomography;
Correlative light and electron microscopy;
Cellular imaging;
Microbiology;
Host-pathogen interaction

Selected Publications

Benjamin C Creekmore†, Kathryn Kixmoeller†, Ben E Black, Edward B Lee*, Yi-Wei Chang*: Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling. Nature Communications 15: 2660, March 2024.

Nicolas Dos Santos Pacheco†, Albert Tell i Puig†, Amandine Guérin†, Matthew Martinez, Bohumil Maco, Nicolò Tosetti, Estefanía Delgado-Betancourt, Matteo Lunghi, Boris Striepen, Yi-Wei Chang*, Dominique Soldati-Favre*: Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins. Nature Communications 15: 379, January 2024.

Matthew Martinez†, Shrawan Kumar Mageswaran†, Amandine Guérin, William David Chen, Cameron Thompson, Sarbin Chavin, Dominique Soldati-Favre, Boris Striepen, Yi-Wei Chang: Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography. Nature Communications 14: 4800, August 2023.

Xiangrui Zeng, Anson Kahng, Liang Xue, Julia Mahamid, Yi-Wei Chang, Min Xu: High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering. Proceedings of the National Academy of Sciences 120: e2213149120, April 2023.

Jose J. Gorbea Colón†, Leon Palao III†, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang*, Kuang-Lei Tsai*, Kenji Murakami*: Structural basis of a transcription pre-initiation complex on a divergent promoter. Molecular Cell 83: 574-588, February 2023.

Matthew Martinez, William David Chen, Marta Cova, Petra Andrea Molnár, Shrawan Kumar Mageswaran, Amandine Guérin, Audrey Ragan Odom John, Maryse Lebrun, Yi-Wei Chang: Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography. Nature Microbiology 7: 1230-1238, August 2022.

Liam Theveny†, Shrawan Kumar Mageswaran†, William David Chen, Matthew Martinez, Amandine Guérin, Yi-Wei Chang: Parasitology meets cryo-electron tomography - exciting prospects await. Trends in Parasitology 38(5): 365-378, May 2022.

Shrawan Kumar Mageswaran, Amandine Guérin†, Liam M. Theveny†, William David Chen†, Matthew Martinez, Maryse Lebrun, Boris Striepen, Yi-Wei Chang: In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems. Nature Communications 12: 4983, August 2021.

Eleonora Aquilini†, Marta Mendonça Cova†, Shrawan Kumar Mageswaran, Nicolas Dos Santos Pacheco, Daniela Sparvoli, Diana Marcela Penarete-Vargas, Rania Najm, Arnault Graindorge, Catherine Suarez, Marjorie Maynadier, Laurence Berry-Sterkers, Serge Urbach, Pilar Ruga Fahy, Amandine Guérin, Boris Striepen, Jean-François Dubremetz, Yi-Wei Chang, Aaron Turkewitz, Maryse Lebrun: An Alveolata secretory machinery adapted to parasite host cell invasion. Nature Microbiology 6: 425–434, January 2021.

Yi-Wei Chang, Songye Chen, Elitza I Tocheva, Anke Treuner-Lange, Stephanie Löbach, Lotte Søgaard-Andersen, Grant J Jensen: Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography. Nature Methods 11(7): 737, July 2014.