Faculty

Kristopher R. Bosse, MD

faculty photo
Assistant Professor of Pediatrics (Oncology)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
Office: 651-492-6726
Fax: 267-426-0685
Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania School of Medicine, 2010.
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Selected Publications

Giudice A, Pascual-Pasto G, Matlaga S, Rouin G, McIntyre B, Schuerch P, Bosse K. : Neuroblastoma extracellular vesicles contain GPC2 and activate GPC2 CAR T cells in an antigen-dependent manner. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Giudice A, Pascual-Pasto G, Matlaga S, Schuerch P, Samanta M, Bosse K. : Development of murine Gpc2 CAR T cells and syngeneic preclinical models to identify mechanisms of immunotherapeutic resistance in neuroblastoma. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Bosse KR, Gladney W, Giudice AM, Pascual-Pasto G, McIntyre B, Foster J, Buongervino S, Lane M, Chagin K, Fountaine TJ, Peddareddigari V, Martinez D, Assenmacher CA, Radaelli E, Pawel B, Grupp S, Barrett D, Maris JM.: GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Pascual-Pasto G, McIntyre B, Giudice AM, Hoffman J, Garcia-Gerique L, Buongervino S, Yararkovich M, Hoffman, TJ, Wolpaw A, Dimitrov D, Li W, Bosse K.: Multi-antigen targeting of neuroblastoma with CAR T-cells secreting bispecific innate immune cell engagers. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Schuerch P, Zecchino VP, McIntyre BC, Groff D, Shraim R, Garrigan E, Bosse K. : CHRNA3 as a super-enhancer-driven oncoprotein and potential immunotherapeutic target in high-risk neuroblastoma. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Bosse KR, Randall MP, Egolf LE, Vaksman Z, Samanta M, Tsang M, Groff D, Evans JP, Rokita JL, Maris JM, Diskin S.: BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. Presented at the Advances in Neuroblastoma Research Congress May 2023.

Randall MP, Egolf LE, Vaksman Z, Samanta M, Tsang M, Groff D, Evans JP, Rokita JL, Layeghifard M, Shlien A, Maris JM, Diskin SJ, Bosse KR. : BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. BioRxiv Page: doi: https://doi.org/10.1101/2023.01.31.525066. February 2023.

Kim J, Vaksman Z, Egolf LE, Kaufman R, Evans JP, Conkrite KL, Danesh A, Lopez G, Randall MP, Dent MH, Farra LM, Menghani N, Dymek M, Desai H, Hausler R, Penn Medicine BioBank, Regeneron Genetics Center, Cancer Genomics Research Laboratory, Auvil JG, Gerhard DS, Hakonarson H, Maxwell KN, Cole KA, Pugh TJ, Bosse KR, Khan J, Wei JS, Maris JM, Stewart DR, Diskin SJ.: Germline pathogenic variants in 786 neuroblastoma patients. MedRxiv Page: doi: https://doi.org/10.1101/2023.01.23.23284864. January 2023.

Bosse KR, Giudice AM, Lane MV, McIntyre B, Schurch PM, Pascual-Pasto G, Buongervino S, Suresh S, Fitzsimmons A, Hyman A, Gemino-Borromeo M, Saggio J, Berko E, Daniels A, Stundon J, Friedrichsen M, Liu X, Margolis M, Li MM, Tierno M, Oxnard G, Maris J, Mosse YP. : Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma. Cancer Discovery 12(12): 2800-2819, December 2022 Notes: doi: 10.1158/2159-8290.CD-22-0287. Online ahead of print.

Pascual-Pasto G, McIntyre B, Shraim R, Buongervino SN, Erbe AK, Zhelev DV, Sadirova S, Giudice AM, Martinez D, Garcia-Gerique L, Dimitrov DS, Sondel PM, Bosse KR. : A GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies. Journal for ImmunoTherapy of Cancer 10(12): e004704, December 2022.

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Last updated: 06/05/2023
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