Faculty

Kristopher R. Bosse, MD

Assistant Professor of Pediatrics

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104

Office: 651-492-6726
Fax: 267-426-0685

Email:
bossek@email.chop.edu

Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2010.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Sussman RT, Rokita JL, Huang K, Raman P, Rathi KS, Martinez D, Bosse KR, Lane M, Hart LS, Bhatti T, Pawel B, Maris JM.: CAMKV is a candidate immunotherapeutic target in MYCN amplified neuroblastoma. Frontiers Oncology 10(302): 1-11, March 2020.

Bosse KR, Majzner RG, Mackall CL, Maris JM. : Immune-based approaches for the treatment of pediatric malignancies. Annual Reviews Cancer Biology 4: 535-70, March 2020.

Heitzeneder S, Bosse KR, Majzner RG, Theruvath JL, Dhingra S, Xu P, Anbunathan H, Alag A, Dimitrov DS, Sotillo E, Maris JM, Mackall CL.: CAR T-cells targeting Glypican-2 effectively eradicate representative neuroblastoma disease models in the absence of toxicity. Presented at the Emerging Cellular Therapies: Cancer and Beyond Keystone Symposia, Alberta, Canada February 2020 Notes: poster.

Chen D, Cox J, Annam J, Weingart M, Essien G, Rathi K, Rokita JL, Khurana P, Cuya SM, Bosse KR, Pilgrim A, Li D, Maris JM, Schnepp RW: LIN28B-PDZ binding kinase signaling promotes neuroblastoma metastasis. Neoplasia In press 2020.

Chen D, Cox J, Annam J, Weingart M, Essien G, Rathi K, Khurana P, Cuya S, Harenza JL, Bosse K, Pilgrim A, Maris JM, Schnepp RW. : A LIN28B-PDZ kinase axis promotes neuroblastoma metastasis. Presented at the American Association for Cancer Research Advances in Pediatric Cancer Research Meeting, Montreal, Canada September 2019 Notes: poster.

Heitzeneder S, Bosse KR, Zhu Z, Majzner RG, Theruvath JL, Xu P, Dhingra S, Anbunathan H, Alag A, Dimitrov DS, Maris JM, Mackall CL. : Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity. Presented at the American Association for Cancer Research Advances in Pediatric Cancer Research Meeting, Montreal, Canada September 2019 Notes: poster.

Bosse KR, Raman S, Buongervino S, Lane M, Upton K, Cui H, Martinez B, Martinez D, Zhelev DV, Pawel B, Dimitrov D, Julien J-P, Maris JM. : Characterization and development of a GPC2 ADC for neuroblastoma and other cancers. Presented at the American Association for Cancer Research Advances in Pediatric Cancer Research Meeting, Montreal, Canada September 2019 Notes: poster.

Heitzeneder S, Bosse KR, Majzner RG, Theruvath JL, Dhingra S, Xu P, Anbunathan H, Alag A, Dimitrov D, Sotillo E, Maris JM, Mackall CL.: Rationally designed Glypican-2 (GPC2) CAR T-cells effectively eradicate endogenous site density solid tumors in the absence of toxicity. Presented at the American Association for Cancer Research Immune Cell Therapies for Cancer: Successes and Challenges of CAR T Cells and Other Forms of Adoptive Therapy Meeting, San Francisco, CA USA July 2019 Notes: poster.

Buongervino S, Lane M, Martinez D, Zhelev DV, Maris J, Dimitrov DS, Bosse KR : Elucidation of the mechanisms of cytotoxicity of the GPC2-targeting antibody-drug conjugate D3-GPC2-PBD in high-risk neuroblastoma. Presented at the Children’s Hospital of Philadelphia Research Poster Day, Philadelphia, PA USA May 2019 Notes: poster.

Foster J, Griffin C, Stern A, Brimley C, Lane M, Buongervino S, Dimitrov DS, Barrett D, Resnick A, Maris J, Bosse K : Development of GPC2-directed chimeric antigen receptor therapy for pediatric brain tumors with in vitro transcribed mRNA Presented at the Society for Neuro-Oncology (SNO) Annual Meeting, San Francisco, CA USA May 2019 Notes: poster.