Jonathan Chernoff

faculty photo
Adjunct Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Fox Chase Cancer Center
333 Cottman Avenue - Room W455
Philadelphia, PA 19111
Office: 215-728-5319
Fax: 215-728-3616
Lab: 215-728-5320
B.A. (Molecular Biophysics/Biochemistry)
Yale College, 1978.
M.D (Biochemistry)
Mount Sinai School of Medicine, 1984.
Ph.D. (Biochemistry)
Mount Sinai School of Medicine, 1984.
Permanent link

Selected Publications

Kosoff Rachelle, Chow Hoi Yee, Radu Maria, Chernoff Jonathan: Pak2 Restrains Mast Cell Fc{varepsilon}RI-Signaling through Modulation of Rho GEF Activity. The Journal of biological chemistry Nov 2012.

Chow Hoi Yee, Jubb Adrian M, Koch Jennifer N, Jaffer Zahara M, Stepanova Dina, Campbell David A, Duron Sergio G, O'Farrell Marie, Cai Kathy Q, Klein-Szanto Andres J P, Gutkind J Silvio, Hoeflich Klaus P, Chernoff Jonathan: p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model. Cancer research 72(22): 5966-75, Nov 2012.

Chiang Yuting Alex, Shao Weijuan, Xu Xiao Xue, Chernoff Jonathan, Jin Tianru: P21-Activated Protein Kinase 1 (Pak1) Mediates the Cross Talk between Insulin and β-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C57BL/6 Mice. Endocrinology Nov 2012.

Menges Craig W, Sementino Eleonora, Talarchek Jacqueline, Xu Jinfei, Chernoff Jonathan, Peterson Jeffrey R, Testa Joseph R: Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Molecular cancer research : MCR 10(9): 1178-88, Sep 2012.

Kelly Mollie L, Chernoff Jonathan: Mouse models of PAK function. Cellular logistics 2(2): 84-88, Apr 2012.

Semenova Galina, Chernoff Jonathan: PKM2 enters the morpheein academy. Molecular cell 45(5): 583-4, Mar 2012.

Yip Shu-Chin, Cotteret Sophie, Chernoff Jonathan: Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. Journal of cell science 125(Pt 2): 310-6, Jan 2012.

Monasky Michelle M, Taglieri Domenico M, Patel Bindiya G, Chernoff Jonathan, Wolska Beata M, Ke Yunbo, Solaro R John: p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. American journal of physiology. Heart and circulatory physiology 302(1): H224-30, Jan 2012.

Hoover Wyn C, Zhang Wenwu, Xue Zhidong, Gao Huanling, Chernoff Jonathan, Clapp D Wade, Gunst Susan J, Tepper Robert S: Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PloS one 7(8): e42601, 2012.

Jhaveri K A, Debnath P, Chernoff J, Sanders J, Schwartz M A: The role of p21-activated kinase in the initiation of atherosclerosis. BMC cardiovascular disorders 12: 55, 2012.

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Last updated: 09/18/2017
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