Faculty

Zachary T Schug, Ph.D.

faculty photo
Wistar Institute Assistant Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Room 531
Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
Office: 6098207478
Lab: 2158983705
Education:
B.S. (Biology)
Saint Joseph's University, 2001.
Ph.D. (Molecular Cell Biology)
Thomas Jefferson University, 2007.
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Description of Research Expertise

Cancer Metabolism
Metabolomics
Lipidomics
Acetate Metabolism
Lipid Metabolism
Functional Genomics
Synthetic Lethality

Selected Publications

Veglia Filippo, Tyurin Vladimir A, Blasi Maria, De Leo Alessandra, Kossenkov Andrew V, Donthireddy Laxminarasimha, To Tsun Ki Jerrick, Schug Zach, Basu Subhasree, Wang Fang, Ricciotti Emanuela, DiRusso Concetta, Murphy Maureen E, Vonderheide Robert H, Lieberman Paul M, Mulligan Charles, Nam Brian, Hockstein Neil, Masters Gregory, Guarino Michael, Lin Cindy, Nefedova Yulia, Black Paul, Kagan Valerian E, Gabrilovich Dmitry I: Fatty acid transport proteinĀ 2 reprograms neutrophils in cancer. Nature 569(7754): 73-78, 05 2019.

Patel Sima, Fu Shuyu, Mastio Jerome, Dominguez George A, Purohit Abhilasha, Kossenkov Andrew, Lin Cindy, Alicea-Torres Kevin, Sehgal Mohit, Nefedova Yulia, Zhou Jie, Languino Lucia R, Clendenin Cynthia, Vonderheide Robert H, Mulligan Charles, Nam Brian, Hockstein Neil, Masters Gregory, Guarino Michael, Schug Zachary T, Altieri Dario C, Gabrilovich Dmitry I: Unique pattern of neutrophil migration and function during tumor progression. Nature immunology 19(11): 1236-1247, 11 2018.

Nacarelli Timothy, Lau Lena, Fukumoto Takeshi, Zundell Joseph, Fatkhutdinov Nail, Wu Shuai, Aird Katherine M, Iwasaki Osamu, Kossenkov Andrew V, Schultz David, Noma Ken-Ichi, Baur Joseph A, Schug Zachary, Tang Hsin-Yao, Speicher David W, David Gregory, Zhang Rugang: NAD metabolism governs the proinflammatory senescence-associated secretome. Nature cell biology 21(3): 397-407, 03 2019.

Schug Zachary T, Peck Barrie, Jones Dylan T, Zhang Qifeng, Grosskurth Shaun, Alam Israt S, Goodwin Louise M, Smethurst Elizabeth, Mason Susan, Blyth Karen, McGarry Lynn, James Daniel, Shanks Emma, Kalna Gabriela, Saunders Rebecca E, Jiang Ming, Howell Michael, Lassailly Francois, Thin May Zaw, Spencer-Dene Bradley, Stamp Gordon, van den Broek Niels J F, Mackay Gillian, Bulusu Vinay, Kamphorst Jurre J, Tardito Saverio, Strachan David, Harris Adrian L, Aboagye Eric O, Critchlow Susan E, Wakelam Michael J O, Schulze Almut, Gottlieb Eyal: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer cell 27(1): 57-71, Jan 2015.

Schug Zachary T, Vande Voorde Johan, Gottlieb Eyal: The metabolic fate of acetate in cancer. Nature reviews. Cancer 16(11): 708-717, 11 2016.

Peck Barrie, Schug Zachary T, Zhang Qifeng, Dankworth Beatrice, Jones Dylan T, Smethurst Elizabeth, Patel Rachana, Mason Susan, Jiang Ming, Saunders Rebecca, Howell Michael, Mitter Richard, Spencer-Dene Bradley, Stamp Gordon, McGarry Lynn, James Daniel, Shanks Emma, Aboagye Eric O, Critchlow Susan E, Leung Hing Y, Harris Adrian L, Wakelam Michael J O, Gottlieb Eyal, Schulze Almut: Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer & metabolism 4: 6, 2016.

Schug Zachary T, Vande Voorde Johan, Gottlieb Eyal: The Nurture of Tumors Can Drive Their Metabolic Phenotype. Cell metabolism 23(3): 391-2, Mar 2016.

Bulusu Vinay, Tumanov Sergey, Michalopoulou Evdokia, van den Broek Niels J, MacKay Gillian, Nixon Colin, Dhayade Sandeep, Schug Zachary T, Vande Voorde Johan, Blyth Karen, Gottlieb Eyal, Vazquez Alexei, Kamphorst Jurre J: Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell reports 18(3): 647-658, 01 2017.

Patella Francesca, Schug Zachary T, Persi Erez, Neilson Lisa J, Erami Zahra, Avanzato Daniele, Maione Federica, Hernandez-Fernaud Juan R, Mackay Gillian, Zheng Liang, Reid Steven, Frezza Christian, Giraudo Enrico, Fiorio Pla Alessandra, Anderson Kurt, Ruppin Eytan, Gottlieb Eyal, Zanivan Sara: Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular & cellular proteomics : MCP 14(3): 621-34, Mar 2015.

Schug Z T, Gonzalvez F, Houtkooper R H, Vaz F M, Gottlieb E: BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell death and differentiation 18(3): 538-48, Mar 2011.

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Last updated: 08/29/2019
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