Faculty
Bin Tian, PhD
Wistar Institute Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations
Contact information
3601 Spruce Street
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: (215) 898-3922
Lab: (215) 898-3920
Lab: (215) 898-3920
Email:
btian@wistar.org
btian@wistar.org
Publications
Education:
Ph.D. (Molecular Biology)
Rutgers Biomedical and Health Sciences (formerly UMDNJ), 2000.
Permanent linkPh.D. (Molecular Biology)
Rutgers Biomedical and Health Sciences (formerly UMDNJ), 2000.
Description of Research Expertise
Molecular Systems Biology, RNA processing, mRNA metabolism, RNA-binding proteins, CancerSelected Publications
Cui Y*, Wang L*, Ding Q, Shin J, Cassel J, Liu Q, Salvino JM, Tian B: Elevated pre-mRNA 3’ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation. Nat Commun. 14(1): 4480, 2023.Shin J, Ding Q, Wang L, Cui Y, Baljinnyam E, Guvenek A, Tian B: CRISPRpas: programmable regulation of alternative polyadenylation by dCas9. Nucleic Acids Res. 50: e25, 2022.
Li WV#, Zheng D, Wang R, Tian B#.: MAAPER: model-based analysis of alternative polyadenylation using 3’ end-linked reads. Genome Biol. 22: 222, 2021.
Cheng LC*, Zheng D*, Zhang Q, Guvenek A, Cheng H, Tian B. : Alternative 3’UTRs play a widespread role in translation-independent mRNA association with endoplasmic reticulum. Cell Rep. 36: 109407, 2021.
Wang R#, Tian B#. : APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms. Bioinformatics. 36: 3907, 2020.
Cheng LC, Zheng D, Baljinnyam E, Sun F, Ogami K, Yeung PL, Hoque M, Shin J, Ding Q, Lu CW, Manley JL, Tian B. : Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation. Nat Commun. 11: 3182, 2020.
Chen S*, Wang R*, Zheng D*, Zhang H*, Chang X, Wang K, Li W, Fan J, Tian B#, Cheng H#. : The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export. Mol Cell. 74: 118-131, 2019.
Wang R, Zheng D, Wei L, Ding Q, Tian B. : Regulation of intronic polyadenylation by PCF11 impacts mRNA expression of long genes. Cell Rep. 26(10): 2766-2778, 2019.
Wang R, Zheng D, Yehia G, Tian B. : A compendium of conserved cleavage and polyadenylation events in mammals. Genome Res. 28: 1427-1441, 2018.
Zheng D*, Wang R*, Ding Q, Wang T, Xie B, Wei L, Zhong Z, Tian B. : Cellular stress alters 3’UTR landscape through alternative polyadenylation and isoform-specific degradation. Nat Commun. 9: 2268, 2018.
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