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Rotem Karni, PhD
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Associate Professor of Genetics
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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One Ucity square, floor 4, room 4018
Philadelphia, 19104
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Education:
21 8 BsC c
3b The Hebrew University of Jerusalem, 1997.
21 a Ph.D. 21 (Biological Chemistry) c
44 The Hebrew University of Jerusalem, Israel., 2002.
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Permanent link21 8 BsC c
3b The Hebrew University of Jerusalem, 1997.
21 a Ph.D. 21 (Biological Chemistry) c
44 The Hebrew University of Jerusalem, Israel., 2002.
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137 Amar-Schwartz A, Cohen Y, Elhaj A, Ben-Hur V, Siegfried Z, Karni R, Dor T.: Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy. Hum Mol Genet 32(15): 2455-2463, Jul 2023.
1b3 Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R.: RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature 617(7959): 147-153, May 2023.
b7 Bashari A, Siegfried Z, Karni R.: Targeting splicing factors for cancer therapy. RNA 29(4): 506-515, Apr 2023.
150 Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas GD, Arbib E, Siegfried Z, Mashahreh B, Hassouna F, Shilo A, Abu-Odeh M, Berger M, Wiener R, Aqeilan R, Geiger T, Karni R.: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair. Elife 11: e79128, Oct 2022.
22f Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE.: Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer. Nat Commun 12(1): 5238, Sep 2021.
b7 Jbara A, Siegfried Z, Karni R.: Splice-switching as cancer therapy. Curr Opin Pharmacol 59: 140-148, Aug 2021.
1c9 Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S, Sade-Feldman M, Tabach Y, Yizhak K, Navon A, Stepensky P, Hacohen N, Peretz T, Veillette A, Karni R, Eisenberg G, Lotem M.: Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions. Cancer Immunol Res 9(6): 637-650, Jun 2021.
ee Halperin O, Karni R, Israeli-Korn S, Hassin-Baer S, Zaidel A.: Overconfidence in visual perception in parkinson's disease. Eur J Neurosci 53(6): 2027-2039, Mar 2021.
149 Goldman-Wohl D, Greenfield C, Eisenberg-Loebl I, Denichenko P, Jbara A, Karni R, Ariel I, Yagel S.: Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development. Placenta 100: 142-149, Oct 2020.
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Selected Publications
11a Yu KM, Trimble DJ, Conner CR, Sheinberg DL, Low GMI, Saluja K, Schmitt KM, Karni RJ.: Oligometastatic Parathyroid Carcinoma Presenting as Neck Pain: A Case Report. Ear Nose Throat J 102(19): 635-639, Oct 2023.137 Amar-Schwartz A, Cohen Y, Elhaj A, Ben-Hur V, Siegfried Z, Karni R, Dor T.: Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy. Hum Mol Genet 32(15): 2455-2463, Jul 2023.
1b3 Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R.: RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature 617(7959): 147-153, May 2023.
b7 Bashari A, Siegfried Z, Karni R.: Targeting splicing factors for cancer therapy. RNA 29(4): 506-515, Apr 2023.
150 Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas GD, Arbib E, Siegfried Z, Mashahreh B, Hassouna F, Shilo A, Abu-Odeh M, Berger M, Wiener R, Aqeilan R, Geiger T, Karni R.: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair. Elife 11: e79128, Oct 2022.
22f Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE.: Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer. Nat Commun 12(1): 5238, Sep 2021.
b7 Jbara A, Siegfried Z, Karni R.: Splice-switching as cancer therapy. Curr Opin Pharmacol 59: 140-148, Aug 2021.
1c9 Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S, Sade-Feldman M, Tabach Y, Yizhak K, Navon A, Stepensky P, Hacohen N, Peretz T, Veillette A, Karni R, Eisenberg G, Lotem M.: Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions. Cancer Immunol Res 9(6): 637-650, Jun 2021.
ee Halperin O, Karni R, Israeli-Korn S, Hassin-Baer S, Zaidel A.: Overconfidence in visual perception in parkinson's disease. Eur J Neurosci 53(6): 2027-2039, Mar 2021.
149 Goldman-Wohl D, Greenfield C, Eisenberg-Loebl I, Denichenko P, Jbara A, Karni R, Ariel I, Yagel S.: Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development. Placenta 100: 142-149, Oct 2020.
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