Hongjun Song

faculty photo
Perelman Professor of Neuroscience
Department: Neuroscience

Contact information
Perelman School of Medicine
Department of Neuroscience
415 Curie Blvd, Suite 111B
1st Floor Clinical Research Building
Philadelphia, PA 19104
Office: 215-573-2449
B.S. (Biology)
Peking University, P.R. China, 1992.
MA, M Phil (Biology)
Columbia University, New York, 1995.
Ph.D. (Biology)
University of California at San Diego, La Jolla, 1998.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Research in Dr. Hongjun Song's laboratory focuses on two core topics: (1) neural stem cell regulation and neurogenesis in the developing and adult mammalian brain and how these processes affect neural function; (2) epigenetic and epitranscriptomic mechanisms and their functions in the mammalian nervous system. The lab is also interested in addressing how dysfunction of these mechanisms may be involved in brain disorders.

Selected Publications

Yoon Ki-Jun, Ringeling Francisca Rojas, Vissers Caroline, Jacob Fadi, Pokrass Michael, Jimenez-Cyrus Dennisse, Su Yijing, Kim Nam-Shik, Zhu Yunhua, Zheng Lily, Kim Sunghan, Wang Xinyuan, Doré Louis C, Jin Peng, Regot Sergi, Zhuang Xiaoxi, Canzar Stefan, He Chuan, Ming Guo-Li, Song Hongjun: Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell 171(4): 877-889.e17, Nov 2017.

Su Yijing, Shin Jaehoon, Zhong Chun, Wang Sabrina, Roychowdhury Prith, Lim Jongseuk, Kim David, Ming Guo-Li, Song Hongjun: Neuronal activity modifies the chromatin accessibility landscape in the adult brain. Nature neuroscience 20(3): 476-483, Mar 2017.

Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C, Yoon KJ, Jeang W, Lin L, Li Y, Thakor J, Berg DA, Zhang C, Kang E, Chickering M, Nauen D, Ho CY, Wen Z, Christian KM, Shi PY, Maher BJ, Wu H, Jin P, Tang H, Song HJ, Ming GL: Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165(5): 1238-54, May 2016.

Shin J, Berg DA, Zhu Y, Shin JY, Song J, Bonaguidi MA, Enikolopov G, Nauen DW, Christian KM, Ming GL, Song HJ: Single-cell RNA-seq with Waterfall reveals molecular cascades underlying adult neurogenesis. Cell Stem Cell 17(3): 360-72, Sep 2015.

Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL, Song HJ: Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience 18(6): 836-43, Jun 2015.

Song J, Zhong C, Bonaguidi MA, Sun GJ, Hsu D, Gu Y, Meletis K, Huang ZJ, Ge S, Enikolopov G, Deisseroth K, Luscher B, Christian KM, Ming GL, Song HJ: Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature 489(7414): 150-4, Sep 2012.

Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song HJ: In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145(7): 1142-55, Jun 2011.

Guo JU, Su Y, Zhong C, Ming GL, Song HJ: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145(3): 423-34, Apr 2011 Notes: (Cover).

Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul Na, Flavell RA, Lu B, Ming GL, Song HJ: Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323(5917): 1074-7, Feb 2009.

Ge S, Goh ELK, Sailor KA, Kitabatake Y, Ming GL, Song HJ: GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439(7076): 589-93, Feb 2006.

back to top
Last updated: 12/12/2017
The Trustees of the University of Pennsylvania