Faculty

Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology

Department: Neurology

Graduate Group Affiliations

Neuroscience

Contact information

The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104

Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671

Email:
goldberge@email.chop.edu

Publications

Search PubMed for articles

Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.

Links
Search PubMed for articles
Goldberg Lab Web Link
Division of Neurology, The Children's Hospital of Philadelphia
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link

Permanent link

NGG Home » NGG Faculty » Epilepsy

Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Prentice, A.J., McSalley, I., Magielski, J.H., Mercurio, J., Tefft, S., Winters, A., Kaufman, M.C., Ruggiero, S.M., McGarry, L., Hood, V., McKee, J.L., Goldberg, E., Helbig, I.: Characterizing SCN1A-Related Disorders Using Real-World Data Across 681 Patient-Years. medRxiv Mar 2026.

Hill, S.F., Goldberg, E.M.: A hit for base editing: Treatment of developmental epilepsy in a mouse model. Journal of Clinical Investigation 136(3): e200689, Feb 2026.

Hill, S.F., Enakhimion, E.A., Furlanis, E., Dai, M., Garcia, B.L., Willis, S., Tran, T., Fishell, G., Wang, Y., Goldberg, E.M.: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome. bioRxiv 2026.02.02.702918, 2026 Notes: doi: https://doi.org/10.64898/2026.02.02.702918.

Dabrowski, A., Somarowthu, A., Liebergall, S., Lorenzo, D., Goldberg, E.M.: Compensatory rearrangement of parvalbumin interneuron voltage-gated sodium channel subunits in a mouse model of Dravet syndrome. Epilepsia 2026.

Ellis, C.A., Copeland, J., Velez, I., Oliver, K.L., Shalaby, H., Baldwin, A., Armstrong, C., Back, A., Berlin, B., Cohen, S., Cuddapah, V.A., deCampo, D., Dubbs, H., Ginn, N., Harrison, A.G., Lewin, N., Lusk, L., Marsh, E.D., Massey, S.L., McDonnell, P.P., McKee, J.L., Ortiz-Gonzalez, X., Prentice, A.J., Sullivan, K.R., Taub, K.S., Ruggiero, S.M., Fitzgerald, M.P., Goldberg, E., Helbig, I.: Genetic testing for familial epilepsies: diagnostic yield and genetic findings. Epilepsia 2026.

Clatot, J., Monnerie, H., Panzer, A., Platzer, K., Goldberg, E.M.: An epilepsy-associated KV3.1 potassium channel variant acts via dominant positive effect. J Gen Physiol 2026.

Sherer, M., Goldberg, E.M.: Flip of the Switch: Targeting GABA Dysregulation to Treat Nonseizure Comorbidities in Dravet Syndrome. Epilepsy Currents Nov 14 2025 Notes: Online ahead of print. doi: 10.1177/15357597251389967.

Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.

Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 Jun 2025.

Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.