Faculty

Delia Maria Talos, MD

faculty photo
Research Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
University of Pennsylvania
Perelman School of Medicine
263 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8328
Fax: 215-662-3362
Education:
MD (Medicine)
University of Cologne, Germany, 1992.
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Description of Research Expertise

1) Key words: epilepsy, neurodevelopment, aging, neuroinflammation

2) Research interests: Neuronal and glial development, synaptic function, epilepsy, autism, cognition.

3) Research techniques: Quantitative protein and gene expression, immunohistochemistry, fluorescence microscopy, transgenic animals, EEG recordings, mouse behavior

4) Research summary: My research focuses on understanding the cellular and molecular mechanisms of epilepsy and its associated neuropsychiatric co-morbidities, with a particular emphasis on genetic, immunological and neurodegenerative processes. The laboratory uses both human brain samples and translational mouse models to study and treat genetic epilepsies such as Tuberous Sclerosis Complex and CDKL5 deficiency disorder, as well as more common forms of epilepsy, caused by status epilepticus, traumatic brain injury and neurodegenerative brain disorders.

Selected Publications

Gourmaud S, Shou H, Irwin DJ, Sansalone K, Jacobs LM, Lucas TH, Marsh ED, Davis KA, Jensen FE* Talos DM*. : Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy Brain 143(1): 191–209, 2020 Notes: *Equal contribution.

Song Y, Jensen FE, Talos DM: Developmental expression of neuronal chloride transporters in different brain regions and sensory organs. Neuronal Chloride Transporters in Health and Disease. Xin Tang (eds.). UK: Academic Press, Page: 215-242, 2020.

Jones JE, Asato MR, Brown MG, Doss JL, Felton EA, Kearney JA, Talos DM, Dacks PA, Whittemore V*, Poduri A* : Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Lifespan Epilepsy Currents Vol. 20(1S): 31S-39S, 2020 Notes: *For the NINDS/AES Benchmarks Stewards Committee

Gourmaud S, Eberwine G, Vassar RJ, Talos DM, Jensen FE : Exacerbation of Alzheimer's Disease Neuropathology by Induced Seizures in the 5XFAD Mouse Model American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 1.287 2019.

Wacker JC, Sansalone K, Yennawar M, Jensen, FE, Talos DM. : Neuronal and Synaptic Pathology in Human CDKL5 Deficiency Disorder. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No. 123.10. Online. 2019 Notes: Poster.

Massa S, Sansalone K, Gourmaud S, Lucas T, Jensen FE, Davis KA, Talos DM. : Dysregulation of Glutamate-Glutamine Cycle Transporters in Human Drug-Resistant Epilepsy American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 1.087. 2019 Notes: Poster.

Roberts N, Ito Y, Talos DM, Jensen FE. : Effects of Perampanel on Hyperthermia-Induced Seizures in a Dravet Syndrome Mouse Model. American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 2.198. 2019 Notes: Poster.

Bagga P, Reddy D, Talos D, Sansalone K, Jacobs L, Verma G, Hariharan H, Reddy R.: Imaging the Effect of High Protein Diet on the Brain Glutaryl-CoA Dehydrogenase Deficient Mice Using GluCEST MRI. International Society for Magnetic Resonance in Medicine, Paris/ France 2018 Notes: Poster.

Gourmaud S, Sansalone K, Irwin DJ, Talos DM, Jensen FE.: Excitation: inhibition imbalance associates with increased pathology in Alzheimer's disease. Society for Neuroscience, San Diego, CA. Neuroscience Meeting Planner. Program No. 738.10. Online. 2018 Notes: Poster.

Talos, DM*, Jacobs LM, Gourmaud, S, Coto, CA, Sun, H, Lim, KC, Lucas TH, Davis, KA, Martinez-Lage, M, Jensen, FE: Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol 83(2): 311-327, 2018 Notes: Corresponding author.

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Last updated: 01/29/2021
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