Faculty

John A. Detre

Professor of Neurology

Department: Neurology

Graduate Group Affiliations

Contact information

3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104

Office: (215) 349-8465
Fax: (215) 614-1927

Email:
DETRE@MAIL.MED.UPENN.EDU

Publications

Search PubMed for articles

Education
B.S. (Chemistry)
Yale University , 1981.
M.D.
Yale University, 1986.

Links
Search PubMed for articles
Brain Science Center website
Lab Website
Neuroscience graduate group faculty webpage.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

KEY WORDS:
magnetic resonance, brain mapping, cerebral blood flow, brain injury

RESEARCH INTERESTS
Brain physiology and pathophysiology of functional activation. Clinical and translational neuroimaging.

RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.

RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, epilepsy, traumatic brain injury, aging, and dementia. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods.

Description of Clinical Expertise

headache, facial pain syndromes, stroke

Selected Publications

Wu, P. H., Rodriguez-Soto, A. E., Wiemken, A., Englund, E. K., Rodgers, Z. B., Langham, M. C., Schwab, R. J., Detre, J. A., Guo, W., Wehrli, F. W.: MRI evaluation of cerebral metabolic rate of oxygen (CMRO2) in obstructive sleep apnea. J Cereb Blood Flow Metab 42(6): 1049-1060, 2022.

Tisdall, M. D., Ohm, D. T., Lobrovich, R., Das, S. R., Mizsei, G., Prabhakaran, K., Ittyerah, R., Lim, S., McMillan, C. T., Wolk, D. A., Gee, J., Trojanowski, J. Q., Lee, E. B., Detre, J. A., Yushkevich, P., Grossman, M., Irwin, D. J.: Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. Neuroimage Clin 33: 102913, 2022.

Quan, P., He, L., Mao, T., Fang, Z., Deng, Y., Pan, Y., Zhang, X., Zhao, K., Lei, H., Detre, J. A., Kable, J. W., Rao, H.: Cerebellum anatomy predicts individual risk-taking behavior and risk tolerance. Neuroimage 254: 119148, 2022.

Moonen, J. E. F., Nasrallah, I. M., Detre, J. A., Dolui, S., Erus, G., Davatzikos, C., Meirelles, O., Bryan, R. N., Launer, L. J.: Race, sex, and mid-life changes in brain health: Cardia MRI substudy. Alzheimers Dement 2022.

Lucas, A., Nanga, R. P. R., Hadar, P., Chen, S., Gibson, A., Oechsel, K., Elliott, M. A., Stein, J. M., Das, S., Reddy, R., Detre, J. A., Davis, K. A.: Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging. Hum Brain Mapp 2022.

Liu, W., Liu, J., Bhavsar, R., Mao, T., Mamikonyan, E., Raizen, D., Detre, J. A., Weintraub, D., Rao, H.: Perfusion Imaging of Fatigue and Time-on-Task Effects in Patients With Parkinson''s Disease. Front Aging Neurosci 14: 901203, 2022.

Kurella Tamura, M., Gaussoin, S., Pajewski, N. M., Zaharchuk, G., Freedman, B. I., Rapp, S. R., Auchus, A. P., Haley, W. E., Oparil, S., Kendrick, J., Roumie, C. L., Beddhu, S., Cheung, A. K., Williamson, J. D., Detre, J. A., Dolui, S., Bryan, R. N., Nasrallah, I. M., Sprint Research Group: Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure. Am J Kidney Dis 79(5): 677-687 e1, 2022.

Kissas, G., Hwuang, E., Thompson, E. W., Schwartz, N., Detre, J. A., Witschey, W. R., Perdikaris, P.: Feasibility of Vascular Parameter Estimation for Assessing Hypertensive Pregnancy Disorders. J Biomech Eng 2022.

Kim, W. S. H., Luciw, N. J., Atwi, S., Shirzadi, Z., Dolui, S., Detre, J. A., Nasrallah, I. M., Swardfager, W., Bryan, R. N., Launer, L. J., MacIntosh, B. J.: Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy. Hum Brain Mapp 43(12): 3680-3693, 2022.

Jiang, H., Simms, A. G., Sadaghiani, S., Jiang, Y. Y., Morgan, J. I. W., Aguirre, G. K., Pattany, P. M., Detre, J. A., Wang, J.: Multi-Center Repeatability of Macular Capillary Perfusion Density Using Optical Coherence Tomography Angiography. Clin Ophthalmol 16: 3069-3078, 2022.