Faculty

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Brian Litt, MD

Perelman Professor of Neurology

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Department: Neurology

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1f Graduate Group Affiliations 8

Bioengineering
Neuroscience

46 Contact information
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Hospital: HUP
1b 3 West Gates / 4283
1a 34th Spruce Street
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1d Lab: 301 Hayden Hall
32 3320 Smith Walk
Philadelphia, PA 19104

30 Office: (215) 746-4850
34 Fax: (215)-349-5733
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Email:
littb@pennmedicine.upenn.edu

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18 Publications
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26 Search PubMed for articles c

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13 Education:
21 9 A.B. c
57 Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
21 9 M.D. e ( ) c
44 Johns Hopkins University School of Medicine, 1986.
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Links
9d Search PubMed for articles
73 Penn Neuroengineering Research Lab
6b Center for Neuroengineering and Therapeutics
68 PennBrain
82 Institute of Neurological Sciences Faculty
c0 News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
147 News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
85 Penn Center for Health, Devices & Technology (Penn Health-Tech)
59 Lab Web Page
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5 3 3 8f Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

fa Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.
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Description of Clinical Expertise

ed Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG
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Description of Other Expertise

23 Entrepreneurship:
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34 I have helped found the following companies:
30 1. IntelliMedix, Inc. Atlanta, GA ~1997
2e 2. Bioquantix, Inc, Atlanta, GA ~2000
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46 I consult or have consulted for the following other companies:
1b 1. NeuroVista, Inc.
28 2. MC10 (agreement under review)
1a 3. Medtronic, Inc.
14 4. KCI, Inc.
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49 I am on the Scientific Advisory Board of the following companies:
1b 1. NeuroVista, Inc.
24 2. MC10 (agreement pending).
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3e I have licensed technology to the following companies:
1a 1. NeuroPace, Inc.
15 2. MC10, Inc.
2e 3. NeuroVista (under potential review)
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57 I have participated in helping bring several implantable NeuroDevices to market.
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Selected Publications

14e Galer PD, McKee JL, Ruggiero SM, Kaufman MC, Ojemann WKS, McSalley I, Ganesan S, Gonzalez AK, Cao Q, Litt B, Helbig I, Conrad EC.: Quantitative EEG Biomarkers in the Genetic Epilepsies and Associations With Neurologic Outcomes. Neurology 105: e214148, Oct 2025.

143 Vizcarra JA, Hefter K, Lafontant DE, Duong MT, Ertefaie A, Litt B, Bassett DS, Siderowf A; Parkinson’s Progression Markers Initiative.: Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis. medRxiv Sep 2025.

120 Sheybani L, Vivekananda U, Sinha N, Conrad E, Litt B, Burgess N, Bush D, Walker MC.: Dynamic Interplay Between Wake Slow Waves and Epileptiform Discharges in the Epileptogenic Zone. Neurology 105: e214001, Sep 2025.

16b Ojemann WKS, Armstrong C, Pattnaik A, Petillo N, Josyula M, Daum A, Zhou DJ, LaRocque J, Korzun J, Kulick-Soper CV, Cornblath EJ, Damaraju S, Shinohara RT, Marsh ED, Davis KA, Litt B, Conrad EC.: Can electrical stimulation replace spontaneous seizures in epilepsy surgery? medRxiv Sep 2025.

13a Ghosn NJ, Walsh K, Xie K, Aguila C, Pattnaik A, Ma D, Krieger A, Conrad E, Litt B.: Inter-ictal spike rates are not modulated by anti-seizure medication taper in the epilepsy monitoring unit: a tale of two confounders. J Neural Eng Sep 2025.

132 Xie K, Korzun J, Zhou DJ, Chang E, Ghosn NJ, Lavelle S, Oganisian A, Acton EK, Gelfand MA, Roth D, Litt B, Ellis CA.: Comparative effectiveness of anti-seizure medications in emulated trials using medical informatics. Brain Jul 2025.

150 Xu Z, Scheid BH, Conrad EC, Davis KA, Ganguly T, Gelfand MA, Gugger JJ, Jiang X, LaRocque JJ, Ojemann WKS, Sinha SR, Waldman GJ, Wagenaar J, Sinha N, Litt B.: Annotating neurophysiologic data at scale with optimized human input. J Neural Eng 22: 046003, Jul 2025.

1b1 Lamberta LK, Asmar M, Fredwall MM, Ahrens SM, Bai S, Eisner M, Lado FA, Schuele SU, Clarke DF, Abdelmoity AT, Davis KA, Hopp JL, Koubeissi MZ, Bensalem Owen MK, Herman ST, Ostendorf AP; NAEC Center Director Study Group.: Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members. Neurology 104: e213689, Jun 2025.

119 Ojemann WKS, Xie K, Liu K, Chang E, Roth D, Litt B, Ellis CA.: Zero-Shot Extraction of Seizure Outcomes from Clinical Notes Using Generative Pretrained Transformers. J Healthc Inform Res 9: 380-400, Apr 2025.

170 Aguila CA, Lucas A, Lavelle S, Pattnaik AR, Kim J, Ojemann WKS, Ma D, Josyula M, Petillo N, LaRocque JJ, Sinha SR, Ellis CA, Parashos A, Gleichgerrcht E, Davis KA, Litt B, Conrad EC.: Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy. Epilepsia 2025.

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26 Last updated: 10/09/2025
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