Claire H. Mitchell, Ph.D.

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Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology

Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Lab: chm@upenn.edu
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Single Ion Channels )
Institute of Ophthalmology, University College London, U.K., 1994.
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Description of Research Expertise

My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.

Selected Publications

Klionsky, D.J.; Abdel-Aziz, A.K.; Abdelfatah et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17: 1-382, 2021.

Campagno, K.E., Mitchell, C.H.: The P2X7 receptor in microglial cells modulates the endolysosomal axis, autophagy and phagocytosis. Frontiers in Cellular Neuroscience 15: 61, 2021.

Hersh, E.V.; Moore, P.A.; Grosser, T.; Polomano, R.C.; Farrar, J.T.; Saraghi, M.; Juska, S.A.; Mitchell, C.H.; Theken, K.N., J Dent Res 2020, 99 (7), 777-786: Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain. J Dent Res 99: 777-786, 2020.

Lally, E.T.; Boesze-Battaglia, K.; Dhingra, A.; Gomez, N.M.; Lora, J.; Mitchell, C.H.; Giannakakis, A.; Fahim, S.A.; Benz, R.; Balashova, N., : Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes. Pathogens 9: 74, 2020.

Guan, H.; Nuth, M.; Lee, V.; Lin, C.; Mitchell, C.H.; Lu, W.; Scott, R.W.; Parker, M.H.; Kulp, J.L., 3rd; Reitz, A.B.; Ricciardi, R.P.: Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis. Ocular Surface 19: 313-321, 2020.

Rossi, H.L.; See, L.P.; Foster, W.; Pitake, S.; Gibbs, J.; Schmidt, B.; Mitchell, C.H.; Abdus-Saboor, I.,: Evoked and spontaneous pain assessment during tooth pulp injury. Sci Rep 10: 2759, 2020.

Shao, X.; Guha, S.; Lu, W.; Campagno, K.E.; Beckel, J.M.; Mills, J.A.; Yang, W.; Mitchell, C.H., : Polarized cytokine release triggered by P2X7 receptor from retinal pigmented epithelial cells dependent on calcium influx. Cells 9: 2537, 2020.

Ventura, A.L.M.; dos Santos-Rodrigues, A.; Mitchell, C.H.; Faillace, M.P.: Purinergic signaling in the retina: From development to disease. Brain Research Bulletin 151: 92-108, 2019.

Li, Ziqing, Liu, Tongjun, Gilmore, Alyssa, Gómez, Néstor Más, Fu, Chuanyun, Lim, Jormay, Yang, Shuting, Mitchell, Claire H, Li, Yi-ping, Oursler, Merry J, Yang, Shuying: Regulator of G protein signaling protein 12 (Rgs12) controls mouse osteoblast differentiation via calcium channel/oscillation and Gαi-ERK signaling. Journal of Bone and Mineral Research(ja), 2019.

Lu, W.; Campagno, K.E.; Tso, H.Y.; Cenaj, A.; Laties, A.M.; Carlsson, L.G.; Mitchell, C.H., : Oral delivery of the P2Y12 receptor antagonist ticagrelor prevents loss of photoreceptors in an ABCA4-/- mouse model of retinal degeneration. Investigative Ophthalmology & Visual Science 60: 3046-3053 2019.

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Last updated: 04/29/2021
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