Faculty

Amelia J. Eisch, Ph.D.

faculty photo
Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Abramson Research Center, Room 402D
3615 Civic Center Drive
Philadelphia, PA 19104-4399
Office: sites.google.com/view/eischlab
Education:
B.A. (Psychology/Biology)
Yale University, 1990.
Ph.D. (Biological Sciences )
University of California, Irvine, 1997.
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Description of Other Expertise

In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.

Description of Research Expertise

I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).

Selected Publications

D Guez-Barber, SE Nicolayevsky, KJ Johnson, S Yun, AJ Eisch. : Microglia Depletion Affects Brain Lesion Size after Hypoxia-Ischemia in Male and Female C57Bl/6J Mice. Child Neurology Society Annual Meeting (CNS, Vancouver), October 2023. Notes: Poster Presentation. Child Neurology Society Annual Meeting (CNS, Vancouver) October 2023 Notes: Notes: Poster Presentation.

SE Nicolayevsky, DJ Russo, AJ Eisch, D Guez-Barber. : Effects Of Microglia Depletion On Brain Lesion Size And Developmental Milestones After Hypoxia-ischemia In Male and Female C57Bl/6J Mice. 148th Annual Meeting of the American Neurological Association (ANA, Philadelphia) September 2023 Notes: Notes: Poster Presentation.

Johnson NS, Kiffer FC, Eisch AJ. : Whole mouse brain analysis of social stimulus-induced changes in cFos 6 months after space radiation exposure. University of Pennsylvania Biomedical Graduate Studies Neuroscience Graduate Group Rotation Presentation. September 2023 Notes: Notes: Oral Presentation.

Hong YR, Mahajan AI, Haas HA, Liebergall SR, Yun S, Eisch AJ, Goldberg EM. : Investigating Pattern Separation Ability in an Epileptic Mouse Model of Dravet Syndrome. University of Pennsylvania Fall 2023 Research Expo September 2023 Notes: Notes: Poster Presentation.

Golynker I, Nicolayevsky SE, Guez-Barber D, Eisch AJ. : The Role of Brain Macrophages in Neonatal Hypoxia Ischemia. University of Pennsylvania Biomedical Graduate Studies Neuroscience Graduate Group Rotation Presentation. September 2023 Notes: Notes: Oral Presentation.

HA Haas, I Soler, C Adams, AJ Eisch, S Yun. : Subanesthetic ketamine’s antidepressant potential: In vivo recording of a mouse memory circuit. University of Pennsylvania Fall 2023 Research Expo September 2023 Notes: Notes: Poster Presentation.

Noh H, Mahajan AI, Hong Y, Eisch AJ, Yun S. : Cellular Pathophysiology of the Hippocampal Dentate Gyrus in a Mouse Model of Dravet Syndrome. The CHOP Research Institute Summer Scholars Program. August 2023 Notes: Notes: Poster Presentation.

HA Haas, I Soler, C Adams, AJ Eisch, S Yun. S: Subanesthetic ketamine’s antidepressant potential: In vivo recording of a mouse memory circuit. University of Pennsylvania Summer Undergraduate Internship Program Scientific Symposium. August 2023 Notes: Notes: Poster Presentation.

Mahajan AI, Yun S, Eisch AJ. : Investigating the Effect of Neuronal Inhibition during Memory Encoding. University of Pennsylvania Vagelos Fellow Summer Presentation. July 2023 Notes: Notes: Oral Presentation.

Johnson KJ, Guez-Barber D, Eisch AJ. : Sex-dependence of perinatal hypoxia-ischemia and the effects of microglia depletion. University of Pennsylvania Vagelos Fellow Summer Presentation. July 2023 Notes: Notes: Oral Presentation.

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Last updated: 08/30/2023
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