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John A. Wolf, Ph.D.
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Research Associate Professor of Neurosurgery
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Department: Neurosurgery
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Contact information
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Rm.172A Stemmler Hall
35 3450 Hamilton Walk
Philadelphia, PA 19104
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35 3450 Hamilton Walk
Philadelphia, PA 19104
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Office: 215-746-4680
3e Lab: 215-898-5102
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Email:
wolfjo@mail.med.upenn.edu
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wolfjo@mail.med.upenn.edu
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Publications
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Education:
21 9 B.A. 14 (Biology) c
33 University of Pennsylvania, 1994.
21 a Ph.D. 19 (Neuroscience) c
33 University of Pennsylvania, 2006.
21 b M.S.Ed 30 (School and Mental Health Counseling) c
33 University of Pennsylvania, 2011.
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Permanent link21 9 B.A. 14 (Biology) c
33 University of Pennsylvania, 1994.
21 a Ph.D. 19 (Neuroscience) c
33 University of Pennsylvania, 2006.
21 b M.S.Ed 30 (School and Mental Health Counseling) c
33 University of Pennsylvania, 2011.
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Description of Research Expertise
199 My laboratory focuses on the effects of traumatic brain injury on the limbic system, including the hippocampus, PFC, and amygdala. We are particularly interested in the changes in coding in these structures, as well as the interactions between them, in both cognition and emotional processing. We are developing new targets of neuromodulation for these regions and their connections as well.26 29
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13d Harary PM, Jgamadze D, Kim J, Wolf JA, Song H, Ming GL, Cullen DK, Chen HI.: Cell Replacement Therapy for Brain Repair: Recent Progress and Remaining Challenges for Treating Parkinson's Disease and Cortical Injury. Brain Sci 13: 1654, Nov 2023.
17b Lu Y, Lee J, Li J, Allu SR, Wang J, Kim H, Bullaughey KL, Fisher SA, Nordgren CE, Rosario JG, Anderson SA, Ulyanova AV, Brem S, Chen HI, Wolf JA, Grady MS, Vinogradov SA, Kim J, Eberwine J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Nat Commun 14: 7346, Nov 2023.
18e Alexandra V. Ulyanova, Carlo Cottone, Christopher D. Adam, Nikhil Maheshwari, Michael R. Grovola, Oceane E. Fruchet, Jami Alamar, Paul F. Koch, Victoria E. Johnson, D. Kacy Cullen, John A. Wolf: Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion. Communications Biology October 2023.
1d9 James P. Harris, Constance J. Mietus, Kevin D. Browne, Kathryn L. Wofford, Carolyn E. Keating, Daniel P. Brown, Brian N. Johnson, John A. Wolf, Douglas H. Smith, Akiva S. Cohen, John E. Duda, D. Kacy Cullen: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study. Frontiers Cellular Neuroscience 17, July 2023.
184 Harris JP, Mietus CJ, Browne KD, Wofford KL, Keating CE, Brown DP, Johnson BN, Wolf JA, Smith DH, Cohen AS, Duda JE, Cullen DK.: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs-An exploratory study. Front Cell Neurosci 17: 1055455, Jul 2023.
16a Eberwine J, Kim J, Anafi RC, Brem S, Bucan M, Fisher SA, Grady MS, Herr AE, Issadore D, Jeong H, Kim H, Lee D, Rubakhin S, Sul JY, Sweedler JV, Wolf JA, Zaret KS, Zou J.: Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput. Nat Methods March 2023.
1e1 Jgamadze D, Lim JT, Zhang Z, Harary PM, Germi J, Mensah-Brown K, Adam CD, Mirzakhalili E, Singh S, Gu JB, Blue R, Dedhia M, Fu M, Jacob F, Qian X, Gagnon K, Sergison M, Fruchet O, Rahaman I, Wang H, Xu F, Xiao R, Contreras D, Wolf JA, Song H, Ming GL, Chen HI.: Structural and functional integration of human forebrain organoids with the injured adult rat visual system. Cell Stem Cell 30: 137-152, Feb 2023.
1ab Smith DH, Burrell JC, Browne KD, Katiyar KS, Ezra MI, Dutton JL, Morand JP, Struzyna LA, Laimo FA, Chen HI, Wolf JA, Kaplan HM, Rosen JM, Ledebur HC, Zager EL, Ali ZS, Cullen DK.: Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs. Sci Adv 8: eabm3291, Nov 2022.
257 Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian: Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open 6(2): 276-296, Jun 2021.
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Selected Publications
40 Adam, Christopher D. 15 Mirzakhalili, Ehsan 15 Gagnon, Kimberly G. 10 Cottone, Carlo 10 Arena, John D. 18 Ulyanova, Alexandra V. 16 Johnson, Victoria E. b2 Wolf, John A.: Disrupted Hippocampal Theta-Gamma Coupling and Spike-field Coherence Following Experimental Traumatic Brain Injury. eLife July 2024.13d Harary PM, Jgamadze D, Kim J, Wolf JA, Song H, Ming GL, Cullen DK, Chen HI.: Cell Replacement Therapy for Brain Repair: Recent Progress and Remaining Challenges for Treating Parkinson's Disease and Cortical Injury. Brain Sci 13: 1654, Nov 2023.
17b Lu Y, Lee J, Li J, Allu SR, Wang J, Kim H, Bullaughey KL, Fisher SA, Nordgren CE, Rosario JG, Anderson SA, Ulyanova AV, Brem S, Chen HI, Wolf JA, Grady MS, Vinogradov SA, Kim J, Eberwine J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Nat Commun 14: 7346, Nov 2023.
18e Alexandra V. Ulyanova, Carlo Cottone, Christopher D. Adam, Nikhil Maheshwari, Michael R. Grovola, Oceane E. Fruchet, Jami Alamar, Paul F. Koch, Victoria E. Johnson, D. Kacy Cullen, John A. Wolf: Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion. Communications Biology October 2023.
1d9 James P. Harris, Constance J. Mietus, Kevin D. Browne, Kathryn L. Wofford, Carolyn E. Keating, Daniel P. Brown, Brian N. Johnson, John A. Wolf, Douglas H. Smith, Akiva S. Cohen, John E. Duda, D. Kacy Cullen: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study. Frontiers Cellular Neuroscience 17, July 2023.
184 Harris JP, Mietus CJ, Browne KD, Wofford KL, Keating CE, Brown DP, Johnson BN, Wolf JA, Smith DH, Cohen AS, Duda JE, Cullen DK.: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs-An exploratory study. Front Cell Neurosci 17: 1055455, Jul 2023.
16a Eberwine J, Kim J, Anafi RC, Brem S, Bucan M, Fisher SA, Grady MS, Herr AE, Issadore D, Jeong H, Kim H, Lee D, Rubakhin S, Sul JY, Sweedler JV, Wolf JA, Zaret KS, Zou J.: Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput. Nat Methods March 2023.
1e1 Jgamadze D, Lim JT, Zhang Z, Harary PM, Germi J, Mensah-Brown K, Adam CD, Mirzakhalili E, Singh S, Gu JB, Blue R, Dedhia M, Fu M, Jacob F, Qian X, Gagnon K, Sergison M, Fruchet O, Rahaman I, Wang H, Xu F, Xiao R, Contreras D, Wolf JA, Song H, Ming GL, Chen HI.: Structural and functional integration of human forebrain organoids with the injured adult rat visual system. Cell Stem Cell 30: 137-152, Feb 2023.
1ab Smith DH, Burrell JC, Browne KD, Katiyar KS, Ezra MI, Dutton JL, Morand JP, Struzyna LA, Laimo FA, Chen HI, Wolf JA, Kaplan HM, Rosen JM, Ledebur HC, Zager EL, Ali ZS, Cullen DK.: Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs. Sci Adv 8: eabm3291, Nov 2022.
257 Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian: Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open 6(2): 276-296, Jun 2021.
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