Faculty

Amelia J. Eisch, Ph.D.

faculty photo
Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Abramson Research Center, Room 402D
3615 Civic Center Drive
Philadelphia, PA 19104-4399
Office: sites.google.com/view/eischlab
Education
B.A. (Psychology/Biology)
Yale University, 1990.
Ph.D. (Biological Sciences )
University of California, Irvine, 1997.
Permanent link
 
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Description of Other Expertise

In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.

Description of Research Expertise

I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).

Selected Publications

Dao CK, Babiker NA, Narain PK, Heredia Piniero V, Yun S, Eisch AJ. : Behavioral Pattern Separation Variability and Approaches to Labeling LEC→DG Terminals. University of Pennsylvania Summer Undergraduate Internship Program Symposium August 2026.

Kiffer FC, Scott RT, Martens MT, Mayo III A, Li Y, Mendoza M, Gautam S, Huang J, Bathwal M, Jaikumar S, Mahajan A, Sanders LM, Eisch AJ, Pereira TD : Automated behavioral segmentation and markerless pose tracking of mice during spaceflight bioRxiv July 2026.

D'ambrosio V, Cohen E, Li Z, Nye E, Kiffer F, Yun S, Roufosse C, Eisch AJ, Siew K: Can an antioxidant/anti-inflammatory compound mitigate the kidney damage caused by galactic cosmic radiation on 2.5 year simulated mission to Mars? ERA26 Congress, Glasgow, Scotland June 2026.

Datta R, Colon LM, Eisch AJ: TRAPed in Place: Machine Learning and Chemogenetics Reveal How the Brain Encodes Fentanyl Memories. UPenn NRSC 4999 Research Symposium April 2026.

Narain P, Butler S, Fesi J, Eisch AJ, Zderic S, Yun S: Early-life bladder inflammation alters locus coeruleus neuronal activity and voiding behavior in adult mice. Mahoney Institute for Neurosciences (MINS) Spring 2026 Symposium April 2026.

Leland SP, Haas HA, Bancroft GL, Shi R, Kumar PL, Eisch AJ, Yun S: Machine learning-based behavioral syllabification links paused motor states to cognitive inflexibility and subanesthetic ketamine recovery in a chronic social defeat stress model in male mice. Mahoney Institute for Neurosciences (MINS) Spring 2026 Symposium April 2026.

Heredia Piñeiro V, Babiker NA, Narain P, Yun S, Eisch AJ: To blur or to separate: Characterizing hippocampal ensemble dynamics in a repeated pattern separation task. NEURON (North East Undergraduate Research Organization for Neuroscience), Quinnipiac University Medical School, North Haven, CT April 2026.

O’Connor SA, Narain PK, Mahajan A, Bancroft GL, Haas HA, Wallen-Friedman E, Vasisht S, Takano H, Kiffer FC, Eisch AJ, Yun S : Circuit-selective cognitive vulnerability to environmental stress: multi-domain assessment of space radiation in both sexes reveals countermeasure trade-offs bioRxiv March 2026.

Colón LM, Famuyide OA, Eisch AJ: Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation. The Journal of Neurochemistry March 2026.

F.C. Kiffer, M.T. Martens, A. Mayo III, Y. Li, M. Mendoza, S. Gautam, J. Huang, M. Bathwal, S. Jaikumar, A. Mahajan, L.M. Sanders, R.T. Scott, A.J. Eisch, T.D. Pereira: AUTOMATED BEHAVIORAL AND KINEMATIC CAPTURE OF MICE ABOARD THE INTERNATIONAL SPACE STATION. NASA Human Research Program 2026 January 2026.

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Last updated: 09/10/2026
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