Faculty

Aaron F Alexander-bloch, MD, PhD, MPhil

faculty photo
Assistant Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
Richards Biomedical Research Laboratories, B504
3700 Hamilton Walk
Philadelphia, PA 19104
Education:
AB (Philosophy)
Harvard College, 2006.
MPhil (Computational Biology)
University of Cambridge, 2008.
PhD (Neuroscience)
University of Cambridge, 2013.
MD
David Geffen School of Medicine at UCLA, 2015.
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Description of Research Expertise

Dr Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness, using a multi-disciplinary approach that integrates brain imaging, genomics and clinical information. The lab team's goal is to translate the highly polygenic risk for psychosis and other neurodevelopmental psychiatric disorders into pathophysiologic mechanisms, to inform therapeutic targets and improve risk assessment. Current projects include: 1) Lifespan trajectory models of post-mortem brain gene expression and brain MRI morphological features (n=100,000 scans including shared and open data); 2) Influence of copy number variants and polygenic risk on brain development and psychiatric risk, in the Philadelphia Neurodevelopmental Cohort; 3) Analysis of clinically-acquired brain MRI at CHOP and integration with natural language processing of physician notes from electronic health record; 4) Transcriptome-wide association study of neuroimaging phenotypes in the UK Biobank. Rotation Projects are available within the scope of each of the above projects.

Selected Publications

Alexander-Bloch, AF, Raznahan, A, Shinohara, RT, Mathias, SR, Bathulapalli, H, Bhalla, IP, Goulet, JL, Satterthwaite, TD, Bassett, DS, Glahn, DC, Brandt, CA: The architecture of co-morbidity networks of physical and mental health conditions in military veterans. proceedings of the royal society a-mathematical physical and engineering sciences 476(2239), JUL 29 2020.

Zhao, K, Ding, YH, Han, Y, Fan, Y, Alexander-Bloch, AF, Han, T, Jin, D, Liu, B, Lu, J, Song, CY, Wang, P, Wang, DW, Wang, Q, Xu, KB, Yang, HW, Yao, HX, Zheng, YJ, Yu, CS, Zhou, B, Zhang, XQ, Zhou, YY, Jiang, TZ, Zhang, X, Liu, Y: Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer?s disease: diagnosis, longitudinal progress and biological basis. science bulletin 65(13): 1103-1113, JUL 15 2020.

Alexander-Bloch, A, Raznahan, A, Vandekar, SN, Seidlitz, J, Lu, ZX, Mathias, SR, Knowles, E, Mollon, J, Rodrigue, A, Curran, JE, Gorring, HHH, Satterthwaite, TD, Gur, RE, Bassett, DS, Hoftman, GD, Pearlson, G, Shinohara, RT, Liu, SY, Fox, PT, Almasy, L, Blangero, J, Glahn, DC: Imaging local genetic influences on cortical folding (vol 117, pg 7430, 2020). proceedings of the national academy of sciences of the united states of america 117(24): 13849, JUN 16 2020.

Mathias, SR, Knowles, EEM, Mollon, J, Rodrigue, A, Koenis, MMC, Alexander-Bloch, AF, Winkler, AM, Olvera, RL, Duggirala, R, Goring, HHH, Curran, JE, Fox, PT, Almasy, L, Blangero, J, Glahn, DC: Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. cerebral cortex 30(6): 3439-3450, JUN 2020.

Cui, ZX, Li, HM, Xia, CH, Larsen, B, Adebimpe, A, Baum, GL, Cieslak, M, Gur, RE, Gur, RC, Moore, TM, Oathes, DJ, Alexander-Bloch, AF, Raznahan, A, Roalf, DR, Shinohara, RT, Wolf, DH, Davatzikos, C, Bassett, DS, Fair, DA, Fan, Y, Satterthwaite, TD: Individual Variation in Functional Topography of Association Networks in Youth. neuron 106(2): 340-+ APR 22 2020.

Ronan, L, Alexander-Bloch, A, Fletcher, PC: Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. cerebral cortex 30(4): 2519-2528, APR 2020.

Xenophontos, A, Seidlitz, J, Liu, SY, Clasen, LS, Blumenthal, JD, Giedd, JN, Alexander-Bloch, A, Raznahan, A: Altered Sex Chromosome Dosage Induces Coordinated Shifts in Cortical Anatomy and Anatomical Covariance. cerebral cortex 30(4): 2215-2228, APR 2020.

Alexander-Bloch, AF, Raznahan, A, Vandekar, SN, Seidlitz, J, Lu, ZX, Matthias, SR, Knowles, E, Mollon, J, Rodrigue, A, Curran, JE, Gorring, HHH, Satterthwaite, TD, Gur, RE, Bassett, DS, Hoftman, GD, Pearlson, G, Shinohara, RT, Liu, SY, Fox, PT, Almasy, L, Blangero, J, Glahn, DC: Imaging local genetic influences on cortical folding. proceedings of the national academy of sciences of the united states of america 117(13): 7430-7436, MAR 31 2020.

Baum, GL, Cui, ZX, Roalf, DR, Ciric, R, Betzel, RF, Larsen, B, Cieslak, M, Cook, PA, Xia, CH, Moore, TM, Ruparel, K, Oathes, DJ, Alexander-Bloch, AF, Shinohara, RT, Raznahan, A, Gur, RE, Gur, RC, Bassett, DS, Satterthwaite, TD: Development of structure-function coupling in human brain networks during youth. proceedings of the national academy of sciences of the united states of america 117(1): 771-778, JAN 7 2020.

Alexander-Bloch, A, Raznahan, A, Vandekar, S, Lu, ZX, Hoftman, G, Seidlitz, J, Liu, SY, Curran, J, Rodrigue, A, Mathias, SR, Mollon, J, Knowles, E, Goring, H, Fox, PT, Pearlson, G, Gur, R, Shinohara, R, Satterthwaite, T, Basset, D, Blangero, J, Glahn, D: Local Genetic Influences on Cortical Folding Characterized With In Vivo Brain MRI: A Possible Mediator of Neuropsychiatric Genetic Risk. neuropsychopharmacology 44(SUPPL 1 1): 101-102, DEC 2019.

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Last updated: 07/27/2020
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