Charles C. Clark, Ph.D.
Emeritus Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Contact information
McKay Orthopaedic Research Laboratory
376A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
376A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8653
Fax: 215-573-2133
Fax: 215-573-2133
Education:
B.A. (Chemistry)
Gannon University, Erie, PA, 1965.
Ph.D. (Biochemistry)
Northwestern University, Chicago, IL, 1970.
Permanent linkB.A. (Chemistry)
Gannon University, Erie, PA, 1965.
Ph.D. (Biochemistry)
Northwestern University, Chicago, IL, 1970.
Selected Publications
Li D., Clark CC., Myers JC.: Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. Journal of Biological Chemistry 275(29): 22339-47, Jul 21 2000.Myers JC., Li D., Rubinstein NA., Clark CC.: Up-regulation of type XIX collagen in rhabdomyosarcoma cells accompanies myogenic differentiation. Experimental Cell Research 253(2): 587-98, Dec 15 1999.
Jones AR., Brighton CT., Clark CC.: Collagen production by microvascular pericytes in long term culture. Trans. Orthop. Res. Soc. 16: 401, 1997.
Chesmel KD., Clark CC., Brighton CT., Black J.: Cellular responses to chemical and morphologic aspects of biomaterial surfaces. II. The biosynthetic and migratory response of bone cell populations. Journal of Biomedical Materials Research 29(9): 1101-10, Sep 1995.
Jones AR., Clark CC., Brighton CT.: Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures. Journal of Orthopaedic Research 13(4): 553-61, Jul 1995.
Bulman WA., Iannotti JP., Glowacki K., Bleuit J., Clark CC.: Serum fractions and related agonists with calcium-mobilizing activity in the bovine growth plate chondrocyte. Journal of Orthopaedic Research 13(2): 220-9, Mar 1995.
Nelson CL., Knight KZ., Clark CC.: The role of type I collagen in osteoblast differentiation. Trans. Orthop. Res. Soc. 20: 460, 1995.
Clark CC., Iannotti JP., Misra S., Richards CF.: Effects of thapsigargin, an intracellular calcium-mobilizing agent, on synthesis and secretion of cartilage collagen and proteoglycan. Journal of Orthopaedic Research 12(5): 601-11, Sep 1994.
Clark CC., Cohen I., Eichstetter I., Cannizzaro LA., McPherson JD., Wasmuth JJ., Iozzo RV.: Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 18(2): 249-60, Nov 1993.
Richardson DW., Clark CC.: Effects of short-term cast immobilization on equine articular cartilage. American Journal of Veterinary Research 54(3): 449-53, Mar 1993.