c
38
b
24
2
4c
16
14
38
1d
1d
a
2
13
c
4
a
19
1
49
5
5
8a
c
e
1b
1d
18
3f
51
1d
2 29
1d
25
Janardhan Prasad Bhattarai, Ph.D.
88
51
Research Assistant Professor of Neuroscience
7
63
Department: Neuroscience
4
1
b
1d
46
Contact information
43
4
3
3
1d
43
109 Johnson Pavilion
50 University of Pennsylvania School of Medicine
Philadelphia, PA 19104
26
50 University of Pennsylvania School of Medicine
Philadelphia, PA 19104
35
99
Email:
janab@pennmedicine.upenn.edu
12
janab@pennmedicine.upenn.edu
18
Publications
23 a
3
2
29
23 a
Links
be Search PubMed for articles
d
4
b
1f
be Search PubMed for articles
d
13
Education:
21 9 B.S. c
43 Hemwati Nandan Bahuguna Garhwal University, 2005.
21 9 M.S. c
35 Chonbuk National University , 2009.
21 a Ph.D. c
34 Chonbuk National University, 2013.
c
3
3
3
3
92
Permanent link21 9 B.S. c
43 Hemwati Nandan Bahuguna Garhwal University, 2005.
21 9 M.S. c
35 Chonbuk National University , 2009.
21 a Ph.D. c
34 Chonbuk National University, 2013.
c
2 29
21
1e
1d
24
2b
29
27
23
256 Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H.: Brain-wide neuronal circuit connectome of human glioblastoma. Nature 641(8061):222-231, May 2025.
12d Janke E, Zhang M, Ryu SE, Bhattarai JP, Schreck MR, Moberly AH, Luo W, Ding L, Wesson DW, Ma M: Machine learning-based clustering and classification of mouse behaviors via respiratory patterns. iScience 25(12): 105625, Nov 2022.
18e Sniffen SE, Ryu SE, Kokoska MM, Bhattarai J, Wang Y, Thomas ER, Skates GM, Johnson NL, Chavez AA, Iaconis SR, Janke E, Zhang YF, Ma M, Wesson DW.: Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions. Mol Psychiatry 30(10):4801-4814, Oct 2025.
100 Schreck MR, Zhuang L, Janke E, Moberly AH, Bhattarai JP, Gottfried JA, Wesson DW, Ma M: State-dependent olfactory processing in freely behaving mice. Cell Rep 38(9): 110450, Mar 2022.
195 Yang K, Hasegawa Y, Bhattarai JP, Hua J, Dower M, Etyemez S, Prasad N, Duvall L, Paez A, Smith A, Wang Y, Zhang YF, Lane AP, Ishizuka K, Kamath V, Ma M, Kamiya A, Sawa A.: Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders. Mol Psychiatry 29(5):1453-1464, May 2024.
16d Choi A, Kim B, Labriola E, Wiest A, Wang Y, Smith J, Shin H, Jin X, An I, Hong J, Antila H, Thomas S, Bhattarai JP, Beier K, Ma M, Weber F, Chung S.: Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience 27(12):111285, Oct 2024.
1cd Zhang YF, Vargas Cifuentes L†, Wright KN†, Bhattarai JP†, Mohrhardt J†, Fleck D†, Janke E, Jiang C, Cranfill SL, Goldstein N, Schreck M, Moberly AH, Yu Y, Arenkiel BR, Betley JN, Luo W, Stegmaier J, Wesson DW, Spehr M, Fuccillo MV, Ma M: Ventral striatal islands of Calleja neurons control grooming in mice. Nat Neurosci 24(12): 1699-1710, dec 2021 Notes: †equal contribution
cd Janke E, Bhattarai JP, Ma M.: Intranasal Pressure Recording for Monitoring Mouse Respiration. Methods Mol Biol 2710:49-60, Sep 2023.
10a Bhattarai JP*, Schreck M, Moberly AH, Luo W, Ma M*: Aversive Learning Increases Release Probability of Olfactory Sensory Neurons. Curr Biol 30(1): 31-41, Jan 2020 Notes: *corresponding authors.
117 Moberly AH, Schreck M, Bhattarai JP, Zweifel LS, Luo W, Ma M: Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior. Nat Commun 9(1): 1528, Apr 2018.
15c Bhattarai P†, Rijal S†, Bhattarai JP, Cho DH, Han SK: Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model. Front Endocrinol (Lausanne) 13: 1059255, Jan 2023 Notes: †equal contribution
110 Bhattarai JP, Roa J, Herbison AE, Han SK: Serotonin acts through 5-HT1 and 5-HT2 receptors to exert biphasic actions on GnRH neuron excitability in the mouse. Endocrinology 155(2): 513-524, Feb 2014.
12e Bhattarai JP†, Kaszás A†, Park SA, Yin H, Park SJ, Herbison AE, Han SK, Abrahám IM: Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice. Endocrinology 2010 Notes: †equal contribution
152 Bhattarai JP†, Park SA†, Park JB, Lee SY, Herbison AE, Ryu PD, Han SK: Tonic extrasynaptic GABA(A) receptor currents control gonadotropin-releasing hormone neuron excitability in the mouse. Endocrinology 152(4): 1551-1561, Apr 2011 Notes: †equal contribution
136 Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W: Glutamate in primary afferents is required for itch transmission. Neuron 110(5): 809-823, Mar 2022.
14b Wang L, Ren W, Li X, Zhang X, Tian H, Bhattarai JP, Challis RC, Lee AC, Zhao S, Yu H, Ma M, Yu Y: Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation. J Neurosci 41(26): 5620-5637, Jun 2021.
104 Bhattarai JP, Park SJ, Chun SW, Cho DH, Han SK: Activation of synaptic and extrasynaptic glycine receptors by taurine in preoptic hypothalamic neurons. Neurosci Lett 608: 51-56, Nov 2015.
f8 Tran PT, Lee YH, Bhattarai JP, Park SJ, Yi HK, Han SK: Existence of ATP sensitive potassium currents on human periodontal ligament cells. Arch Oral Biol 76: 48-54, April 2017.
128 Nguyen TT, Bhattarai JP, Park SJ, Han SK: Activation of glycine and extrasynaptic GABA(A) receptors by taurine on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis. Neural Plast 2013: 740581, Nov 2013.
15d Porteous R, Petersen SL, Yeo SH, Bhattarai JP, Ciofi P, de Tassigny XD, Colledge WH, Caraty A, Herbison AE: Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus. J Comp Neurol 519: 3456-3469, Dec 2011.
147 Dhungel KU, Kim TW, Sharma N, Bhattarai JP, Park SA, Han SK, Kim CJ: Magnesium increases iberiotoxin-sensitive large conductance calcium activated potassium currents on the basilar artery smooth muscle cells in rabbits. Neurol Res 34(1): 11-16, Jan 2012.
11c Sharma N†, Bhattarai JP†, Hwang PH, Han SK: Nitric oxide suppresses L-type calcium currents in basilar artery smooth muscle cells in rabbits. Neurol Res 35(4): 424-428, May 2013 Notes: †equal contribution
f3 Bhattarai JP, Ábrahám IM, Han SK: Genistein Excitation of Gonadotropin-Releasing Hormone Neurons in Juvenile Female Mice. J Neuroendocrinology 25(5): 497-505, May 2013.
2c
7
1d
1f
Selected Publications
13c Bhattarai JP, Etyemez S, Jaaro-Peled H, Janke E, Leon Tolosa UD, Kamiya A, Gottfried JA, Sawa A, Ma M: Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition. Semin Cell Dev Biol 129: 31-39, Sep 2022.256 Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H.: Brain-wide neuronal circuit connectome of human glioblastoma. Nature 641(8061):222-231, May 2025.
12d Janke E, Zhang M, Ryu SE, Bhattarai JP, Schreck MR, Moberly AH, Luo W, Ding L, Wesson DW, Ma M: Machine learning-based clustering and classification of mouse behaviors via respiratory patterns. iScience 25(12): 105625, Nov 2022.
18e Sniffen SE, Ryu SE, Kokoska MM, Bhattarai J, Wang Y, Thomas ER, Skates GM, Johnson NL, Chavez AA, Iaconis SR, Janke E, Zhang YF, Ma M, Wesson DW.: Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions. Mol Psychiatry 30(10):4801-4814, Oct 2025.
100 Schreck MR, Zhuang L, Janke E, Moberly AH, Bhattarai JP, Gottfried JA, Wesson DW, Ma M: State-dependent olfactory processing in freely behaving mice. Cell Rep 38(9): 110450, Mar 2022.
195 Yang K, Hasegawa Y, Bhattarai JP, Hua J, Dower M, Etyemez S, Prasad N, Duvall L, Paez A, Smith A, Wang Y, Zhang YF, Lane AP, Ishizuka K, Kamath V, Ma M, Kamiya A, Sawa A.: Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders. Mol Psychiatry 29(5):1453-1464, May 2024.
16d Choi A, Kim B, Labriola E, Wiest A, Wang Y, Smith J, Shin H, Jin X, An I, Hong J, Antila H, Thomas S, Bhattarai JP, Beier K, Ma M, Weber F, Chung S.: Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience 27(12):111285, Oct 2024.
1cd Zhang YF, Vargas Cifuentes L†, Wright KN†, Bhattarai JP†, Mohrhardt J†, Fleck D†, Janke E, Jiang C, Cranfill SL, Goldstein N, Schreck M, Moberly AH, Yu Y, Arenkiel BR, Betley JN, Luo W, Stegmaier J, Wesson DW, Spehr M, Fuccillo MV, Ma M: Ventral striatal islands of Calleja neurons control grooming in mice. Nat Neurosci 24(12): 1699-1710, dec 2021 Notes: †equal contribution
cd Janke E, Bhattarai JP, Ma M.: Intranasal Pressure Recording for Monitoring Mouse Respiration. Methods Mol Biol 2710:49-60, Sep 2023.
10a Bhattarai JP*, Schreck M, Moberly AH, Luo W, Ma M*: Aversive Learning Increases Release Probability of Olfactory Sensory Neurons. Curr Biol 30(1): 31-41, Jan 2020 Notes: *corresponding authors.
117 Moberly AH, Schreck M, Bhattarai JP, Zweifel LS, Luo W, Ma M: Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior. Nat Commun 9(1): 1528, Apr 2018.
15c Bhattarai P†, Rijal S†, Bhattarai JP, Cho DH, Han SK: Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model. Front Endocrinol (Lausanne) 13: 1059255, Jan 2023 Notes: †equal contribution
110 Bhattarai JP, Roa J, Herbison AE, Han SK: Serotonin acts through 5-HT1 and 5-HT2 receptors to exert biphasic actions on GnRH neuron excitability in the mouse. Endocrinology 155(2): 513-524, Feb 2014.
12e Bhattarai JP†, Kaszás A†, Park SA, Yin H, Park SJ, Herbison AE, Han SK, Abrahám IM: Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice. Endocrinology 2010 Notes: †equal contribution
152 Bhattarai JP†, Park SA†, Park JB, Lee SY, Herbison AE, Ryu PD, Han SK: Tonic extrasynaptic GABA(A) receptor currents control gonadotropin-releasing hormone neuron excitability in the mouse. Endocrinology 152(4): 1551-1561, Apr 2011 Notes: †equal contribution
136 Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W: Glutamate in primary afferents is required for itch transmission. Neuron 110(5): 809-823, Mar 2022.
14b Wang L, Ren W, Li X, Zhang X, Tian H, Bhattarai JP, Challis RC, Lee AC, Zhao S, Yu H, Ma M, Yu Y: Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation. J Neurosci 41(26): 5620-5637, Jun 2021.
104 Bhattarai JP, Park SJ, Chun SW, Cho DH, Han SK: Activation of synaptic and extrasynaptic glycine receptors by taurine in preoptic hypothalamic neurons. Neurosci Lett 608: 51-56, Nov 2015.
f8 Tran PT, Lee YH, Bhattarai JP, Park SJ, Yi HK, Han SK: Existence of ATP sensitive potassium currents on human periodontal ligament cells. Arch Oral Biol 76: 48-54, April 2017.
128 Nguyen TT, Bhattarai JP, Park SJ, Han SK: Activation of glycine and extrasynaptic GABA(A) receptors by taurine on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis. Neural Plast 2013: 740581, Nov 2013.
15d Porteous R, Petersen SL, Yeo SH, Bhattarai JP, Ciofi P, de Tassigny XD, Colledge WH, Caraty A, Herbison AE: Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus. J Comp Neurol 519: 3456-3469, Dec 2011.
147 Dhungel KU, Kim TW, Sharma N, Bhattarai JP, Park SA, Han SK, Kim CJ: Magnesium increases iberiotoxin-sensitive large conductance calcium activated potassium currents on the basilar artery smooth muscle cells in rabbits. Neurol Res 34(1): 11-16, Jan 2012.
11c Sharma N†, Bhattarai JP†, Hwang PH, Han SK: Nitric oxide suppresses L-type calcium currents in basilar artery smooth muscle cells in rabbits. Neurol Res 35(4): 424-428, May 2013 Notes: †equal contribution
f3 Bhattarai JP, Ábrahám IM, Han SK: Genistein Excitation of Gonadotropin-Releasing Hormone Neurons in Juvenile Female Mice. J Neuroendocrinology 25(5): 497-505, May 2013.
2c
26
1b
c
Contact Us
34Department of Neuroscience
2
43
Perelman School of Medicine at the University of Pennsylvania
14
415 Curie Blvd
1c
Philadelphia, PA 19104
6
19
Fax: (215) 573-0833
2
51
(215) 898-8754
2
5d
Email Us
2
e8
54
6
13