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Franz Weber, Ph.D.
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Associate Professor of Neuroscience
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Department: Neuroscience
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Graduate Group Affiliations
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- Cell and Molecular Biology 41
- Bioengineering 64
- Neuroscience 6a
- Pharmacology e
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Contact information
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Department of Neuroscience,
1e Chronobiology Program,
24 Perelman School of Medicine,
22 University of Pennsylvania
26 10-132 Smilow Research Center
43 3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
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1e Chronobiology Program,
24 Perelman School of Medicine,
22 University of Pennsylvania
26 10-132 Smilow Research Center
43 3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
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Office: 215-898-0254
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Publications
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Education:
21 a B.Sc. 1b (Bioinformatics) c
5b Ludwig Maximilians University Munich / Technical University Munich, 2006.
21 a M.Sc. 1a (Neurosciences) c
3d Ludwig Maximilians University Munich, 2009.
21 8 PhD 23 (Systemic Neurosciences) c
3d Max Planck Institute of Neurobiology, 2011.
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Permanent link21 a B.Sc. 1b (Bioinformatics) c
5b Ludwig Maximilians University Munich / Technical University Munich, 2006.
21 a M.Sc. 1a (Neurosciences) c
3d Ludwig Maximilians University Munich, 2009.
21 8 PhD 23 (Systemic Neurosciences) c
3d Max Planck Institute of Neurobiology, 2011.
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aa We are interested in the neural and homeostatic mechanisms controlling REM sleep and the functional role of this brain state in emotional memories and behaviors.
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19 Research Projects
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1a5 We study REM sleep and its functional roles in the mouse model. Our lab employs a wide range of methods including optogenetics, in vivo electrophysiology, calcium imaging, viral tracing and quantitative modeling to disentangle the neural and homeostatic mechanisms controlling REM sleep. We further seek to develop a circuit-based understanding of how REM sleep affects emotional behaviors in health and disease.
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10 Keywords
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9b Sleep, REM sleep, neural circuits, in vivo electrophysiology, calcium imaging, modeling, optogenetics, viral traching, Chronobiology, gene profiling
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Description of Research Expertise
23 Research Interests8
aa We are interested in the neural and homeostatic mechanisms controlling REM sleep and the functional role of this brain state in emotional memories and behaviors.
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19 Research Projects
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1a5 We study REM sleep and its functional roles in the mouse model. Our lab employs a wide range of methods including optogenetics, in vivo electrophysiology, calcium imaging, viral tracing and quantitative modeling to disentangle the neural and homeostatic mechanisms controlling REM sleep. We further seek to develop a circuit-based understanding of how REM sleep affects emotional behaviors in health and disease.
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10 Keywords
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9b Sleep, REM sleep, neural circuits, in vivo electrophysiology, calcium imaging, modeling, optogenetics, viral traching, Chronobiology, gene profiling
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dd J. Hong, D. Lozano, K.T. Beier, S. Chung, F. Weber : Prefrontal cortical regulation of REM sleep. Nature Neuroscience 26(10): 1820-1832, Oct 2023.
dd A.L. Schott, J. Baik, S. Chung, F. Weber : A medullary hub for controlling REM sleep and pontine waves. Nature Communications 14(1): 3922, Jul 2023.
f5 J.A. Stucynski, A.L. Schott, J. Baik, S. Chung, F. Weber : Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla. Current Biology 32(1): 37-50, Jan 2021.
10c S.H. Park, J. Baik, J. Hong, H. Antila, B. Kurland, S. Chung, F. Weber : A probabilistic model for the ultradian timing of REM sleep in mice. PLOS Computational Biology 17(8): e1009316, Aug 2021.
d6 Weber F, Chung S, Beier KT, Xu M, Luo L, Dan Y: Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8, Oct 2015.
12a Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S: Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545(7655): 477-481, May 2017.
3a Weber F, Dan Y 71 : Circuit-based interrogation of sleep control. Nature 538(7623): 51-59, Oct 2016.
f7 Weber F, Machens CK, Borst A: Disentangling the functional consequences of the connectivity between optic-flow processing neurons. Nature Neuroscience 15(3): 441-8, Mar 2012.
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Selected Publications
100 J. Hong, K. Choi, M.V. Fuccillo, S. Chung, F. Weber: Infralimbic activity during REM sleep facilitates extinction memory consolidation. Current Biology 34(10): 2247-2255.E5, May 2024.dd J. Hong, D. Lozano, K.T. Beier, S. Chung, F. Weber : Prefrontal cortical regulation of REM sleep. Nature Neuroscience 26(10): 1820-1832, Oct 2023.
dd A.L. Schott, J. Baik, S. Chung, F. Weber : A medullary hub for controlling REM sleep and pontine waves. Nature Communications 14(1): 3922, Jul 2023.
f5 J.A. Stucynski, A.L. Schott, J. Baik, S. Chung, F. Weber : Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla. Current Biology 32(1): 37-50, Jan 2021.
10c S.H. Park, J. Baik, J. Hong, H. Antila, B. Kurland, S. Chung, F. Weber : A probabilistic model for the ultradian timing of REM sleep in mice. PLOS Computational Biology 17(8): e1009316, Aug 2021.
d6 Weber F, Chung S, Beier KT, Xu M, Luo L, Dan Y: Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8, Oct 2015.
12a Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S: Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545(7655): 477-481, May 2017.
3a Weber F, Dan Y 71 : Circuit-based interrogation of sleep control. Nature 538(7623): 51-59, Oct 2016.
f7 Weber F, Machens CK, Borst A: Disentangling the functional consequences of the connectivity between optic-flow processing neurons. Nature Neuroscience 15(3): 441-8, Mar 2012.
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Contact Us
34Department of Neuroscience
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Perelman School of Medicine at the University of Pennsylvania
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415 Curie Blvd
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Philadelphia, PA 19104
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Fax: (215) 573-0833
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(215) 898-8754
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Email Us
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