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Shinjae Chung, Ph.D.
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Associate Professor of Neuroscience
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Department: Neuroscience
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Graduate Group Affiliations
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- Pharmacology 64
- Neuroscience 6b
- Cell and Molecular Biology 41
- Bioengineering e
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Contact information
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Department of Neuroscience
29 Chronobiology and Sleep Institute
23 Perelman School of Medicine
22 University of Pennsylvania
3d Smilow Center for Translational Research, Room 10-133
44 3400 Civic Center Blvd. Bldg. 421
Philadelphia, PA 19151
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29 Chronobiology and Sleep Institute
23 Perelman School of Medicine
22 University of Pennsylvania
3d Smilow Center for Translational Research, Room 10-133
44 3400 Civic Center Blvd. Bldg. 421
Philadelphia, PA 19151
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Education:
21 9 B.S. 2c (Life Sciences and Biotechnology) c
29 Korea University, 2002.
21 a Ph.D. 39 (Pharmacology; Developmental and Cell Biology) c
39 University of California, Irvine, 2008.
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Permanent link21 9 B.S. 2c (Life Sciences and Biotechnology) c
29 Korea University, 2002.
21 a Ph.D. 39 (Pharmacology; Developmental and Cell Biology) c
39 University of California, Irvine, 2008.
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3e Neural circuits for sleep and emotional brain function
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11 Key words
5c Sleep, neuropsychiatric diseases, hypothalamus, stress, neurodevelopmental disorders
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1b Research techniques
85 Optogenetics, deep brain calcium imaging, in vivo physiology, gene profiling, virus-mediated circuit mapping, sleep recording
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18 Research summary
186 The goal of our lab is to identify the molecular and neural mechanisms controlling sleep, and to understand how these are interconnected with the neural circuits regulating emotional states in health and disease. To accomplish this, we employ a multi-disciplinary approach including optogenetics, in vivo electrophysiology, imaging, virus-mediated circuit mapping and gene profiling.
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Description of Research Expertise
23 Research interests3e Neural circuits for sleep and emotional brain function
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11 Key words
5c Sleep, neuropsychiatric diseases, hypothalamus, stress, neurodevelopmental disorders
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1b Research techniques
85 Optogenetics, deep brain calcium imaging, in vivo physiology, gene profiling, virus-mediated circuit mapping, sleep recording
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18 Research summary
186 The goal of our lab is to identify the molecular and neural mechanisms controlling sleep, and to understand how these are interconnected with the neural circuits regulating emotional states in health and disease. To accomplish this, we employ a multi-disciplinary approach including optogenetics, in vivo electrophysiology, imaging, virus-mediated circuit mapping and gene profiling.
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174 Choi A, Kim B, Labriola E, Wiest A, Wang Y, Smith J, Shin H,Jin X, An I, Hong J, Antila H, Thomas S, Bhattarai JP, Beier KT, Ma M, Weber F, and Chung S. : Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience 27(12): 111285, Dec 2024.
104 Smith J, Honig-Frand A, Antila H, Beier K, Weber F, Chung S. : Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons. Current Biology 34(1): 12-23, Jan 2024.
116 Maurer J, Lin A, Jin X, Hong J, Sathi N, Cardis R, Osorio-Forero A, Lüthi A, Weber, F, Chung S. : Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus. eLife 12: RP92095, Jun 2024.
d6 Hong J, Lozano DE, Beier KT, Chung S, Weber F: Prefrontal cortical regulation of REM sleep. Nature Neuroscience 26(10): 1820-1832, Oct 2023.
15b Antila H, Kwak I, Choi A, Pisciotti A, Covarrubias I, Baik J, Eisch A, Beier K, Thomas S, Weber F, Chung S. : A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances. Proceedings of the National Academy of Sciences 119(45): e2123528119, Nov 2022.
ee Stucynski JA, Schott AL, Baik J, Chung S, Weber F: Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla. Current Biology 32(1): 37-50, Jan 2022.
16b Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y. : Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545: 477–481, May 2017.
12f Xu M, Chung S, Zhang S, Zhong P, Ma C, Chang WC, Weissbourd B, Sakai N, Luo L, Nishino S, Dan Y: Basal forebrain circuit for sleep-wake control. Nature Neuroscience 18(11): 1641-7, Nov 2015 Notes: Xu and Chung are co-first author.
d6 Weber F, Chung S, Beier KT, Xu M, Luo L, Dan Y: Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8, Oct 2015.
119 Chung S, Liao XH, Di Cosmo C, Van Sande J, Wang Z, Refetoff S, Civelli O: Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology 153(12): 6145-54, Dec 2012.
121 Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O: The melanin-concentrating hormone system modulates cocaine reward. Proceedings of the National Academy of Sciences, USA 106(16): 6772-7, Apr 2009.
177 Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O: The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. European Journal of Pharmacology 602(2-3): 194-202, Jan 2009 Notes: Nagasaki and Chung are co-first author.
126 Chung S, Pohl S, Zeng J, Civelli O, Reinscheid RK: Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance. The Journal of Pharmacology and Experimental Therapeutics 318(1): 262-7, Jul 2006.
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Selected Publications
106 Wiest A, Maurer JJ, Beier KT, Weber F, Chung S: A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep. Journal of Neuroscience 45(27): e2146242025, July 2025.174 Choi A, Kim B, Labriola E, Wiest A, Wang Y, Smith J, Shin H,Jin X, An I, Hong J, Antila H, Thomas S, Bhattarai JP, Beier KT, Ma M, Weber F, and Chung S. : Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience 27(12): 111285, Dec 2024.
104 Smith J, Honig-Frand A, Antila H, Beier K, Weber F, Chung S. : Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons. Current Biology 34(1): 12-23, Jan 2024.
116 Maurer J, Lin A, Jin X, Hong J, Sathi N, Cardis R, Osorio-Forero A, Lüthi A, Weber, F, Chung S. : Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus. eLife 12: RP92095, Jun 2024.
d6 Hong J, Lozano DE, Beier KT, Chung S, Weber F: Prefrontal cortical regulation of REM sleep. Nature Neuroscience 26(10): 1820-1832, Oct 2023.
15b Antila H, Kwak I, Choi A, Pisciotti A, Covarrubias I, Baik J, Eisch A, Beier K, Thomas S, Weber F, Chung S. : A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances. Proceedings of the National Academy of Sciences 119(45): e2123528119, Nov 2022.
ee Stucynski JA, Schott AL, Baik J, Chung S, Weber F: Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla. Current Biology 32(1): 37-50, Jan 2022.
16b Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y. : Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545: 477–481, May 2017.
12f Xu M, Chung S, Zhang S, Zhong P, Ma C, Chang WC, Weissbourd B, Sakai N, Luo L, Nishino S, Dan Y: Basal forebrain circuit for sleep-wake control. Nature Neuroscience 18(11): 1641-7, Nov 2015 Notes: Xu and Chung are co-first author.
d6 Weber F, Chung S, Beier KT, Xu M, Luo L, Dan Y: Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8, Oct 2015.
119 Chung S, Liao XH, Di Cosmo C, Van Sande J, Wang Z, Refetoff S, Civelli O: Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology 153(12): 6145-54, Dec 2012.
121 Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O: The melanin-concentrating hormone system modulates cocaine reward. Proceedings of the National Academy of Sciences, USA 106(16): 6772-7, Apr 2009.
177 Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O: The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. European Journal of Pharmacology 602(2-3): 194-202, Jan 2009 Notes: Nagasaki and Chung are co-first author.
126 Chung S, Pohl S, Zeng J, Civelli O, Reinscheid RK: Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance. The Journal of Pharmacology and Experimental Therapeutics 318(1): 262-7, Jul 2006.
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Contact Us
34Department of Neuroscience
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Perelman School of Medicine at the University of Pennsylvania
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415 Curie Blvd
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Philadelphia, PA 19104
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Fax: (215) 573-0833
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