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Ethan M. Goldberg, M.D., Ph.D.
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Associate Professor of Neurology
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Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
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Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
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Department: Neurology
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Graduate Group Affiliations
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- Neuroscience e
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Contact information
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The Children's Hospital of Philadelphia
1d Division of Neurology
2b Abramson Research Center, Room 510D
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
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1d Division of Neurology
2b Abramson Research Center, Room 510D
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
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Office: 215-590-6894
32 Fax: 215-590-1771
32 Lab: 215-590-5671
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32 Fax: 215-590-1771
32 Lab: 215-590-5671
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Email:
goldberge@email.chop.edu
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goldberge@email.chop.edu
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Publications
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Links
e1 Search PubMed for articles
95 Division of Neurology, The Children's Hospital of Philadelphia
7a The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
5b Goldberg Lab Web Link
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e1 Search PubMed for articles
95 Division of Neurology, The Children's Hospital of Philadelphia
7a The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
5b Goldberg Lab Web Link
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Education:
21 9 B.A. 19 (Neurobiology) c
2b Harvard University, 1999.
21 a Ph.D. 26 (Physiology & Neuroscience) c
3f New York University School of Medicine, 2006.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 2008.
21 a Cert. 6d (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER)) c
39 University of Wisconsin-Madison , 2022.
21 a Cert. 31 (Raising a Resilient Scientist Series) c
6d National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
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Permanent link21 9 B.A. 19 (Neurobiology) c
2b Harvard University, 1999.
21 a Ph.D. 26 (Physiology & Neuroscience) c
3f New York University School of Medicine, 2006.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 2008.
21 a Cert. 6d (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER)) c
39 University of Wisconsin-Madison , 2022.
21 a Cert. 31 (Raising a Resilient Scientist Series) c
6d National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
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Description of Clinical Expertise
8e Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.71
Description of Research Expertise
60 Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.e 29
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182 Hill, S.F., Enakhimion, E.A., Furlanis, E., Dai, M., Garcia, B.L., Willis, S., Tran, T., Fishell, G., Wang, Y., Goldberg, E.M.: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome. bioRxiv 2026.02.02.702918, 2026 Notes: doi: https://doi.org/10.64898/2026.02.02.702918.
232 Ellis, C.A., Copeland, J., Velez, I., Oliver, K.L., Shalaby, H., Baldwin, A., Armstrong, C., Back, A., Berlin, B., Cohen, S., Cuddapah, V.A., deCampo, D., Dubbs, H., Ginn, N., Harrison, A.G., Lewin, N., Lusk, L., Marsh, E.D., Massey, S.L., McDonnell, P.P., McKee, J.L., Ortiz-Gonzalez, X., Prentice, A.J., Sullivan, K.R., Taub, K.S., Ruggiero, S.M., Fitzgerald, M.P., Goldberg, E., Helbig, I.: Genetic testing for familial epilepsies: diagnostic yield and genetic findings. Epilepsia 2026.
f9 Clatot, J., Monnerie, H., Panzer, A., Platzer, K., Goldberg, E.M.: An epilepsy-associated KV3.1 potassium channel variant acts via dominant positive effect. J Gen Physiol 2026.
127 Sherer, M., Goldberg, E.M.: Flip of the Switch: Targeting GABA Dysregulation to Treat Nonseizure Comorbidities in Dravet Syndrome. Epilepsy Currents Nov 14 2025 Notes: Online ahead of print. doi: 10.1177/15357597251389967.
134 Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.
181 Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. 50 bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 1e Jun 2025.
1c9 Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.
3a6 Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron 32 113(10): 1525-1547, May 2025.
1e5 Clatot, J., Thompson, C.H., Susan Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S.M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, Jr., A.L., Goldberg, E.M.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.
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Selected Publications
ef Hill, S.F., Goldberg, E.M.: A hit for base editing: Treatment of developmental epilepsy in a mouse model. Journal of Clinical Investigation 136(3): e200689, Feb 2026.182 Hill, S.F., Enakhimion, E.A., Furlanis, E., Dai, M., Garcia, B.L., Willis, S., Tran, T., Fishell, G., Wang, Y., Goldberg, E.M.: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome. bioRxiv 2026.02.02.702918, 2026 Notes: doi: https://doi.org/10.64898/2026.02.02.702918.
232 Ellis, C.A., Copeland, J., Velez, I., Oliver, K.L., Shalaby, H., Baldwin, A., Armstrong, C., Back, A., Berlin, B., Cohen, S., Cuddapah, V.A., deCampo, D., Dubbs, H., Ginn, N., Harrison, A.G., Lewin, N., Lusk, L., Marsh, E.D., Massey, S.L., McDonnell, P.P., McKee, J.L., Ortiz-Gonzalez, X., Prentice, A.J., Sullivan, K.R., Taub, K.S., Ruggiero, S.M., Fitzgerald, M.P., Goldberg, E., Helbig, I.: Genetic testing for familial epilepsies: diagnostic yield and genetic findings. Epilepsia 2026.
f9 Clatot, J., Monnerie, H., Panzer, A., Platzer, K., Goldberg, E.M.: An epilepsy-associated KV3.1 potassium channel variant acts via dominant positive effect. J Gen Physiol 2026.
127 Sherer, M., Goldberg, E.M.: Flip of the Switch: Targeting GABA Dysregulation to Treat Nonseizure Comorbidities in Dravet Syndrome. Epilepsy Currents Nov 14 2025 Notes: Online ahead of print. doi: 10.1177/15357597251389967.
134 Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.
181 Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. 50 bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 1e Jun 2025.
1c9 Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.
3a6 Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron 32 113(10): 1525-1547, May 2025.
1e5 Clatot, J., Thompson, C.H., Susan Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S.M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, Jr., A.L., Goldberg, E.M.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.
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