Joel D. Mainland, PhD

Adjunct Associate Professor of Neuroscience
Department: Neuroscience
Graduate Group Affiliations
Contact information
Monell Chemical Senses Center
3500 Market Street
Philadelphia, PA 19104
3500 Market Street
Philadelphia, PA 19104
Email:
jmainland@monell.org
jmainland@monell.org
Publications
Education:
Bachelor (Neuroscience)
Columbia University, 2001.
PhD (Neuroscience)
University of California at Berkeley, 2006.
Permanent linkBachelor (Neuroscience)
Columbia University, 2001.
PhD (Neuroscience)
University of California at Berkeley, 2006.
Description of Research Expertise
Research InterestsDevelop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
Keywords
olfactory receptor, psychophysics, coding, cell culture, human
Research Details
A fundamental problem in neuroscience is mapping the physical properties of a stimulus to perceptual characteristics. In vision, wavelength translates into color; in audition, frequency translates into pitch. By contrast, the mapping from chemical structure to olfactory percept is unknown. In other words, there is not a scientist or perfumer in the world who can view a novel molecular structure and predict how it will smell. My research goal is to develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
Selected Publications
Mainland JD, Matsunami H. : RAMP-like proteins: RTP and REEP family of proteins. Receptor Activity Modifying Proteins. Spielman W and Parameswaran N, ed (eds.). Feb 2012.Mainland Joel D, Matsunami Hiroaki: Taste perception: how sweet it is (to be transcribed by you). Current Biology 19(15): R655-6, Aug 2009.
Matsunami H, Mainland JD, Dey S: Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Annals of the New York Academy of Sciences 1170: 153-6, Jul 2009.
Saito Harumi, Chi Qiuyi, Zhuang Hanyi, Matsunami Hiroaki, Mainland Joel D: Odor coding by a Mammalian receptor repertoire. Science signaling 2(60): ra9, Mar 2009.
Mainland JD, Sobel N: The sniff is part of the olfactory percept. Chemical Senses 31(2): 181-96, Feb 2006.
Mainland JD, Johnson BN, Khan R, Ivry RB, Sobel N: Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril. The Journal of Neuroscience 25(27): 6362-71, Jul 2005.
Zelano C, Bensafi M, Porter J, Mainland J, Johnson B, Bremner E, Telles C, Khan R, Sobel N: Attentional modulation in human primary olfactory cortex. Nature Neuroscience 8(1): 114-20, Jan 2005.
Bensafi M, Zelano CM, Johnson BN, Mainland JD, Khan R, Sobel N: Olfaction: From Sniff to Percept. The Cognitive Neurosciences, 3rd Edition Gazzaniga MS, ed (eds.). Camridge, MA: MIT Press, Page: 259-280, 2004.
Bensafi M, Brown WM, Tsutsui T, Mainland JD, Johnson BN, Bremner EA, Young N, Mauss I, Ray B, Gross J, Richards J, Stappen I, Levenson RW, Sobel N: Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behavioral Neuroscience 117(6): 1125-34, Dec 2003.
Bensafi M, Porter J, Pouliot S, Mainland J, Johnson B, Zelano C, Young N, Bremner E, Aframian D, Khan R, Sobel N: Olfactomotor activity during imagery mimics that during perception. Nature Neuroscience 6(11): 1142-4, Nov 2003.