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Joel D. Mainland, PhD
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Adjunct Professor of Neuroscience
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Department: Neuroscience
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Graduate Group Affiliations
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- Neuroscience e
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Contact information
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Monell Chemical Senses Center
35 3500 Market Street
Philadelphia, PA 19104
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35 3500 Market Street
Philadelphia, PA 19104
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Email:
jmainland@monell.org
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jmainland@monell.org
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Publications
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Education:
21 d Bachelor 19 (Neuroscience) c
2c Columbia University, 2001.
21 8 PhD 19 (Neuroscience) c
3d University of California at Berkeley, 2006.
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Permanent link21 d Bachelor 19 (Neuroscience) c
2c Columbia University, 2001.
21 8 PhD 19 (Neuroscience) c
3d University of California at Berkeley, 2006.
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90 Develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
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10 Keywords
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46 olfactory receptor, psychophysics, coding, cell culture, human
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18 Research Details
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253 A fundamental problem in neuroscience is mapping the physical properties of a stimulus to perceptual characteristics. In vision, wavelength translates into color; in audition, frequency translates into pitch. By contrast, the mapping from chemical structure to olfactory percept is unknown. In other words, there is not a scientist or perfumer in the world who can view a novel molecular structure and predict how it will smell. My research goal is to develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
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Description of Research Expertise
23 Research Interests8
90 Develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
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10 Keywords
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46 olfactory receptor, psychophysics, coding, cell culture, human
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18 Research Details
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253 A fundamental problem in neuroscience is mapping the physical properties of a stimulus to perceptual characteristics. In vision, wavelength translates into color; in audition, frequency translates into pitch. By contrast, the mapping from chemical structure to olfactory percept is unknown. In other words, there is not a scientist or perfumer in the world who can view a novel molecular structure and predict how it will smell. My research goal is to develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.
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d4 Mainland Joel D, Matsunami Hiroaki: Taste perception: how sweet it is (to be transcribed by you). Current Biology 19(15): R655-6, Aug 2009.
fe Matsunami H, Mainland JD, Dey S: Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Annals of the New York Academy of Sciences 1170: 153-6, Jul 2009.
eb Saito Harumi, Chi Qiuyi, Zhuang Hanyi, Matsunami Hiroaki, Mainland Joel D: Odor coding by a Mammalian receptor repertoire. Science signaling 2(60): ra9, Mar 2009.
b3 Mainland JD, Sobel N: The sniff is part of the olfactory percept. Chemical Senses 31(2): 181-96, Feb 2006.
130 Mainland JD, Johnson BN, Khan R, Ivry RB, Sobel N: Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril. The Journal of Neuroscience 25(27): 6362-71, Jul 2005.
10a Zelano C, Bensafi M, Porter J, Mainland J, Johnson B, Bremner E, Telles C, Khan R, Sobel N: Attentional modulation in human primary olfactory cortex. Nature Neuroscience 8(1): 114-20, Jan 2005.
11b Bensafi M, Zelano CM, Johnson BN, Mainland JD, Khan R, Sobel N: Olfaction: From Sniff to Percept. The Cognitive Neurosciences, 3rd Edition Gazzaniga MS, ed (eds.). Camridge, MA: MIT Press, Page: 259-280, 2004.
179 Bensafi M, Brown WM, Tsutsui T, Mainland JD, Johnson BN, Bremner EA, Young N, Mauss I, Ray B, Gross J, Richards J, Stappen I, Levenson RW, Sobel N: Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behavioral Neuroscience 117(6): 1125-34, Dec 2003.
12b Bensafi M, Porter J, Pouliot S, Mainland J, Johnson B, Zelano C, Young N, Bremner E, Aframian D, Khan R, Sobel N: Olfactomotor activity during imagery mimics that during perception. Nature Neuroscience 6(11): 1142-4, Nov 2003.
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Selected Publications
f3 Mainland JD, Matsunami H. : RAMP-like proteins: RTP and REEP family of proteins. Receptor Activity Modifying Proteins. Spielman W and Parameswaran N, ed (eds.). Feb 2012.d4 Mainland Joel D, Matsunami Hiroaki: Taste perception: how sweet it is (to be transcribed by you). Current Biology 19(15): R655-6, Aug 2009.
fe Matsunami H, Mainland JD, Dey S: Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Annals of the New York Academy of Sciences 1170: 153-6, Jul 2009.
eb Saito Harumi, Chi Qiuyi, Zhuang Hanyi, Matsunami Hiroaki, Mainland Joel D: Odor coding by a Mammalian receptor repertoire. Science signaling 2(60): ra9, Mar 2009.
b3 Mainland JD, Sobel N: The sniff is part of the olfactory percept. Chemical Senses 31(2): 181-96, Feb 2006.
130 Mainland JD, Johnson BN, Khan R, Ivry RB, Sobel N: Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril. The Journal of Neuroscience 25(27): 6362-71, Jul 2005.
10a Zelano C, Bensafi M, Porter J, Mainland J, Johnson B, Bremner E, Telles C, Khan R, Sobel N: Attentional modulation in human primary olfactory cortex. Nature Neuroscience 8(1): 114-20, Jan 2005.
11b Bensafi M, Zelano CM, Johnson BN, Mainland JD, Khan R, Sobel N: Olfaction: From Sniff to Percept. The Cognitive Neurosciences, 3rd Edition Gazzaniga MS, ed (eds.). Camridge, MA: MIT Press, Page: 259-280, 2004.
179 Bensafi M, Brown WM, Tsutsui T, Mainland JD, Johnson BN, Bremner EA, Young N, Mauss I, Ray B, Gross J, Richards J, Stappen I, Levenson RW, Sobel N: Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behavioral Neuroscience 117(6): 1125-34, Dec 2003.
12b Bensafi M, Porter J, Pouliot S, Mainland J, Johnson B, Zelano C, Young N, Bremner E, Aframian D, Khan R, Sobel N: Olfactomotor activity during imagery mimics that during perception. Nature Neuroscience 6(11): 1142-4, Nov 2003.
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Contact Us
34Department of Neuroscience
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Perelman School of Medicine at the University of Pennsylvania
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