Faculty

Bin Tian, PhD

Wistar Institute Professor of Biochemistry and Biophysics

Department: Biochemistry and Biophysics

Graduate Group Affiliations

Contact information

3601 Spruce Street
Philadelphia, PA 19104

Office: (215) 898-3922
Lab: (215) 898-3920

Email:
btian@wistar.org

Publications

Search PubMed for articles

Education:
Ph.D. (Molecular Biology)
Rutgers Biomedical and Health Sciences (formerly UMDNJ), 2000.

Links
Search PubMed for articles
Lab Page

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Molecular Systems Biology, RNA processing, mRNA metabolism, RNA-binding proteins, Cancer

Selected Publications

Cui Y*, Wang L*, Ding Q, Shin J, Cassel J, Liu Q, Salvino JM, Tian B: Elevated pre-mRNA 3’ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation. Nat Commun. 14(1): 4480, 2023.

Shin J, Ding Q, Wang L, Cui Y, Baljinnyam E, Guvenek A, Tian B: CRISPRpas: programmable regulation of alternative polyadenylation by dCas9. Nucleic Acids Res. 50: e25, 2022.

Li WV#, Zheng D, Wang R, Tian B#.: MAAPER: model-based analysis of alternative polyadenylation using 3’ end-linked reads. Genome Biol. 22: 222, 2021.

Cheng LC*, Zheng D*, Zhang Q, Guvenek A, Cheng H, Tian B. : Alternative 3’UTRs play a widespread role in translation-independent mRNA association with endoplasmic reticulum. Cell Rep. 36: 109407, 2021.

Wang R#, Tian B#. : APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms. Bioinformatics. 36: 3907, 2020.

Cheng LC, Zheng D, Baljinnyam E, Sun F, Ogami K, Yeung PL, Hoque M, Shin J, Ding Q, Lu CW, Manley JL, Tian B. : Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation. Nat Commun. 11: 3182, 2020.

Chen S*, Wang R*, Zheng D*, Zhang H*, Chang X, Wang K, Li W, Fan J, Tian B#, Cheng H#. : The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export. Mol Cell. 74: 118-131, 2019.

Wang R, Zheng D, Wei L, Ding Q, Tian B. : Regulation of intronic polyadenylation by PCF11 impacts mRNA expression of long genes. Cell Rep. 26(10): 2766-2778, 2019.

Wang R, Zheng D, Yehia G, Tian B. : A compendium of conserved cleavage and polyadenylation events in mammals. Genome Res. 28: 1427-1441, 2018.

Zheng D*, Wang R*, Ding Q, Wang T, Xie B, Wei L, Zhong Z, Tian B. : Cellular stress alters 3’UTR landscape through alternative polyadenylation and isoform-specific degradation. Nat Commun. 9: 2268, 2018.