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John H. Holmes, PhD, FACE, FACMI, FIAHSI
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Professor of Medical Informatics in Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
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Department: Biostatistics and Epidemiology
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Graduate Group Affiliations
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Contact information
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401 Blockley Hall
35 423 Guardian Drive
Philadelphia, PA 19104
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35 423 Guardian Drive
Philadelphia, PA 19104
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Office: 215-898-4833
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33 Fax: 215-573-5325
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Publications
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Education:
21 9 A.B. 16 (Sociology) c
33 University of Pennsylvania, 1976.
21 9 M.S. 20 (Information Systems) c
2a Drexel University, 1987.
21 a Ph.D. 20 (Information Science) c
2a Drexel University, 1996.
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21 9 A.B. 16 (Sociology) c
33 University of Pennsylvania, 1976.
21 9 M.S. 20 (Information Systems) c
2a Drexel University, 1987.
21 a Ph.D. 20 (Information Science) c
2a Drexel University, 1996.
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Links
19a Search PubMed for articles
43 Center for Clinical Epidemiology and Biostatistics faculty
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Permanent link19a Search PubMed for articles
43 Center for Clinical Epidemiology and Biostatistics faculty
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Description of Research Expertise
ca medical informatics; data mining; evolutionary computation; machine learning; artificial intelligence; database design and implementation for clinical research; medical decision making;26 29
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130 Sultan L, Venkatakrishna SSB, Anupindi S, Andronikou S, Acord M, Otero H, Holmes JH: ChatGPT-4-Driven Liver Ultrasound Radiomics Analysis: Advantages and Drawbacks Compared to Traditional Techniques. JMIR AI doi:10.2196/68144 2025.
1c4 Skarke C, Yang W, Sha D, Lahens NF, Isakova T, Unruh M, Deo R, Carmona-Powell E, Holmes JH, Ficarra E, Chen J, Jiang He, Rincon-Choles H, Shah V, Hsu CY, Anderson AH, Lash JP, Rahman M: A multi-center study to discern the diurnal variation of wearable device-based heart rate variability (HRV) in the Chronic Renal Insufficiency Cohort (CRIC) Study. npj Digit. Med. 8(653), 2025.
f4 Beidler E, Teel E, Schmitt AJ, Muccio G, Holmes JH, Bretzin AC: Anxiety-Related Concussion Perceptions of Parents of Youth Athletes. Journal of Athletic Training Dec 2024.
152 Moutchia J, McClelland RL, Al-Naamani N, Appleby, Holmes JH, Minhas J, Mazurek JA, Palevsky HI, Ventetuolo CE, Kawut SM: Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis. European Heart Journal Page: ehae049, Feb 2024.
1dd Getzen E, Tan AL, Brat G, Omenn GS, Strasser Z; Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (Collaborative Group/Consortium); Long Q, Holmes JH, Mowery D: Leveraging informative missing data to learn about acute respiratory distress syndrome and mortality in long-term hospitalized COVID-19 patients throughout the years of the pandemic. AMIA Annu Symp Proc Page: 942-950, Jan 2024.
16b Minhas J, Moutchia J, Al-Naamani N, Mazurek JA, Holmes JH, Appleby D, Smith KA, Fritz JS, Pugliese SC, Palevsky HI, Kawut SM: Electrocardiographic Abnormalities and Their Association with Outcomes in Randomized Clinical Trials of Pulmonary Arterial Hypertension. Ann Am Thorac Soc Jan 2024.
105 Bretzin AC, Schmitt AJ, Teel E, Holmes JH, Wiebe DJ, Beidler E: Parent and Youth Athlete Perceptions of Concussion Injury: Establishing a Factor Structure. Arch Clin Neuropsychol Jan 2024.
f9 Koch S, Holmes JH, Sacchi L: Unlocking the Potential of the Next Generation: Methods of Information in Medicine Student Paper Award 2024. Methods Inf Med 63(3-04): 63-65, 2024.
16d Dixon BE, Holmes JH: Special Section on Digital Health for Precision in Prevention: Notable Papers that Leverage Informatics Approaches to Support Precision Prevention Efforts in Health Systems. International Medical Informatics Association Yearbook of Medical Informatics 33(1): 70-72, 2024.
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Selected Publications
170 Lutfi W, Pan Z, Grasty MA, Goel NJ, Catalano MA, Sperry AE, Szeto J, Kurzan P, Lawrence KM, Desai, ND, Szeto WY, Holmes JH, Brown CR: Cardiac Valve Prosthesis Choice for Left-sided Infective Endocarditis in Medicare Patients. JTCVS Open. https://doi.org/10.1016/j.xjon.2025.09.050 November 2025.130 Sultan L, Venkatakrishna SSB, Anupindi S, Andronikou S, Acord M, Otero H, Holmes JH: ChatGPT-4-Driven Liver Ultrasound Radiomics Analysis: Advantages and Drawbacks Compared to Traditional Techniques. JMIR AI doi:10.2196/68144 2025.
1c4 Skarke C, Yang W, Sha D, Lahens NF, Isakova T, Unruh M, Deo R, Carmona-Powell E, Holmes JH, Ficarra E, Chen J, Jiang He, Rincon-Choles H, Shah V, Hsu CY, Anderson AH, Lash JP, Rahman M: A multi-center study to discern the diurnal variation of wearable device-based heart rate variability (HRV) in the Chronic Renal Insufficiency Cohort (CRIC) Study. npj Digit. Med. 8(653), 2025.
f4 Beidler E, Teel E, Schmitt AJ, Muccio G, Holmes JH, Bretzin AC: Anxiety-Related Concussion Perceptions of Parents of Youth Athletes. Journal of Athletic Training Dec 2024.
152 Moutchia J, McClelland RL, Al-Naamani N, Appleby, Holmes JH, Minhas J, Mazurek JA, Palevsky HI, Ventetuolo CE, Kawut SM: Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis. European Heart Journal Page: ehae049, Feb 2024.
1dd Getzen E, Tan AL, Brat G, Omenn GS, Strasser Z; Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (Collaborative Group/Consortium); Long Q, Holmes JH, Mowery D: Leveraging informative missing data to learn about acute respiratory distress syndrome and mortality in long-term hospitalized COVID-19 patients throughout the years of the pandemic. AMIA Annu Symp Proc Page: 942-950, Jan 2024.
16b Minhas J, Moutchia J, Al-Naamani N, Mazurek JA, Holmes JH, Appleby D, Smith KA, Fritz JS, Pugliese SC, Palevsky HI, Kawut SM: Electrocardiographic Abnormalities and Their Association with Outcomes in Randomized Clinical Trials of Pulmonary Arterial Hypertension. Ann Am Thorac Soc Jan 2024.
105 Bretzin AC, Schmitt AJ, Teel E, Holmes JH, Wiebe DJ, Beidler E: Parent and Youth Athlete Perceptions of Concussion Injury: Establishing a Factor Structure. Arch Clin Neuropsychol Jan 2024.
f9 Koch S, Holmes JH, Sacchi L: Unlocking the Potential of the Next Generation: Methods of Information in Medicine Student Paper Award 2024. Methods Inf Med 63(3-04): 63-65, 2024.
16d Dixon BE, Holmes JH: Special Section on Digital Health for Precision in Prevention: Notable Papers that Leverage Informatics Approaches to Support Precision Prevention Efforts in Health Systems. International Medical Informatics Association Yearbook of Medical Informatics 33(1): 70-72, 2024.
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