Faculty

Michael J. Gandal, MD, Ph.D.

William & Noreen Hetznecker Associate Professor in Psychiatry

Department: Psychiatry

Graduate Group Affiliations

Contact information

3615 Civic Center Blvd
Abramson Pediatric Research Center, 1016C
Philadelphia, PA 19104

Office: 215-573-4438
Fax: 844-316-5129

Publications

Search PubMed for articles

Education:
BS (Engineering (concentration in Biomedical Computation))
Stanford University, 2006.
Ph.D (Bioengineering)
University of Pennsylvania, 2011.
MD (Medical Scientist Training Program (MSTP), Clinical Neuroscience Training Program )
University of Pennsylvania, 2013.

Links
Search PubMed for articles
Gandal Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

adolescents and adults with neurodevelopmental psychiatric disorders

Description of Research Expertise

Research Interests: We integrate computational biology and functional genomics in the human brain to understand the genetic mechanisms contributing to -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders.

Keywords: Psychiatric genetics, functional genomics, transcriptomics, human brain development, gene network biology, neurodevelopmental disorders, genome-wide association studies (GWAS), whole genome sequencing, Autism Spectrum Disorder (ASD), ADHD, bipolar disorder, and schizophrenia.

Research Details, Rotation Projects, Lab Personnel
See: www.gandallab.org

Selected Publications

Tsai YC, Ozaki H, Wang X, Almet AA, Fleming I, Shiraiwa K, Noh MJM, Nie C, Trejo S, Sugita BK, Dalal J, Gonzalez RA, De Jesus B, Chen GL, Gandal MJ, Nie Q, Watanabe M.: Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology. bioRxiv Sep 2025.

Sha Z, Sun KY, Jung B, Barzilay R, Moore TM, Almasy L, Forsyth JK, Prem S, Gandal MJ, Seidlitz J, Glessner JT, Alexander-Bloch AF.: Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study. Am J Psychiatry 182: 763-778, Aug 2025.

Vuong CK, Weber A, Seong P, Matoba N, Shafie B, Salinda A, Zhang P, Chen YJ, Nichterwitz S, Younesi S, Qi L, Gandal MJ, Geschwind DH, Stein JL, de la Torre-Ubieta L.: A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex. bioRxiv Jul 2025.

Hernandez LM, Amirtha Ganesh SS, Gandal MJ, Fuligni AJ.: Genetic prediction of early adolescent chronotype: effects of sex and pubertal status. Sleep 48: zsaf094, Jun 2025.

Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hettema JM, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Robinson EB, Sanchez-Roige SS, Santangelo SL, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR; Anxiety Disorders Working Group; Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group; Autism Spectrum Disorders Working Group; Bipolar Disorder Working Group; Eating Disorders Working Group; Major Depressive Disorder Working Group; Nicotine Dependence GenOmics (iNDiGO) Consortium; Obsessive-Compulsive Disorder Working Group; Post-Traumatic Stress Disorder Working Group; Schizophrenia Working Group; Substance Use Disorders Working Group; Tourette Syndrome Working Group; Lee PH, Kendler KS, Smoller JW.: The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders. medRxiv Jan 2025.

Cai N, Verhulst B, Andreassen OA, Buitelaar J, Edenberg HJ, Hettema JM, Gandal M, Grotzinger A, Jonas K, Lee P, Mallard TT, Mattheisen M, Neale MC, Nurnberger JI Jr, Peyrot WJ, Tucker-Drob EM, Smoller JW, Kendler KS.: Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research. Mol Psychiatry 2025.

Cai N, Verhulst B, Andreassen OA, Buitelaar J, Edenberg HJ, Hettema JM, Gandal M, Grotzinger A, Jonas K, Lee P, Mallard TT, Mattheisen M, Neale MC, Nurnberger JI Jr, Peyrot WJ, Tucker-Drob EM, Smoller JW, Kendler KS.: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research. Mol Psychiatry 2025.

Aygün N, Vuong C, Krupa O, Mory J, Le BD, Valone JM, Liang D, Shafie B, Zhang P, Salinda A, Wen C, Gandal MJ, Love MI, de la Torre-Ubieta L, Stein JL.: Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis. Am J Hum Genet 111: 1877-1898, Sep 2024.

Sha Z, Sun KY, Jung B, Barzilay R, Moore TM, Almasy L, Forsyth JK, Prem S, Gandal MJ, Seidlitz J, Glessner JT, Alexander-Bloch AF.: The copy number variant architecture of psychopathology and cognitive development in the ABCD (®) study. medRxiv May 2024.

Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM; PsychENCODE Consortium‡; Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS; PsychENCODE Consortium.: Massively parallel characterization of regulatory elements in the developing human cortex. Science 384: eadh0559, May 2024.