Faculty

Pablo G Cámara, PhD

Associate Professor of Genetics

Department: Genetics

Graduate Group Affiliations

Contact information

D105 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104-6145

Office: 215-746-3545

Email:
pcamara@pennmedicine.upenn.edu

Education:
BS (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2002.
PhD (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2006.

Links
Camara Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Research in the Camara lab is focused on the development and application of innovative computational approaches to the study of cellular heterogeneity and its role in disease. To this end, we draw ideas from topology, geometry, statistics, physics, and computer science. Combining these approaches with the use of high-throughput single-cell technologies and large-scale population studies, we aim to achieve a better understanding of the cellular composition and cell-to-cell signaling networks of tumors in relation to their genomes. We are particularly interested in deciphering the cellular ecosystem and heterotypic signaling networks of tumors of the central nervous system, both in adults and children; however, we expect our methods to be of utility to a broader community and collaborate with groups working in related areas of research.

Selected Publications

Zoga, K., Villiere, S., Tikiyani, V., Edwards-Cintron, F., Thokachichu, P., Nicodemus, P., Camara, P. G., Hart, M. P.: Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories. bioRxiv 2025.

Noller, K., Botsis, T., Camara, P. G., Ciotti, L., Cooper, L. A., Goecks, J., Griffith, M., Haas, B. J., Ideker, T., Karchin, R., Kontos, D., Lai, J., Marcus, D., Meyer, C. A., Naegle, K., Pati, S., Peters, B., Pratt, D., Raphael, B. J., Reich, M., Savova, G. K., Wright, C., Fertig, E. J., Bakas S.: Informatics at the frontier of cancer research. Cancer Research 2025.

Camara, P. G.: Quantum information in Riemannian spaces. Journal of Physics A: Mathematical and Theoretical 58: 225304, 2025.

Aubin, R. G., Montelongo, J., Hu, R., Gunther, E., Nicodemus, P., Camara, P. G.: Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. Cell Reports Methods 4: 100905, 2024.

Bai, Z., Feng, B., McClory, S. E., Coutinho de Oliveira, B., Diorio, C., Gregoire, C., Tao, B., Yang, L., Zhao, Z., Peng, L., Sferruzza, G., Zhou, L., Zhou, X., Kerr, J., Baysoy, A., Su, G., Yang, M., Camara, P. G., Chen, S., Tang, L.*, June, C. H.*, Melenhorst, J. J.*, Grupp, S. A.*, Fan, R.*: Single-cell CAR T atlas reveals type2 function in 8-year leukemia remission. Nature 634: 702-711, 2024.

Govek, K. W., Nicodemus, P., Lin, Y., Crawford, J., Saturnino, A. B., Cui, H., Zoga, K., Hart, M. P., Camara, P. G.: CAJAL enables analysis and integration of single-cell morphological data using metric geometry. Nature Communications 14: 3672, 2023.

Bai, Z.*, Woodhouse, S.*, Zhao, Z., Arya, R., Govek, K., Kim, D., Lundh, S., Baysoy, A., Sun, H., Deng, Y., Xiao, Y., Barrett, D. M., Myers, R. M., Grupp, S. A., June, C. H., Fan, R.#, Camara, P. G.#, Melenhorst, J. J.#: Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science Advances 8: eabj2820, 2022 Notes: #corresponding authors. *authors contributed equally.

Govek, K. W., Crawford, J., Saturnino, A. B., Zoga, K., Hart, M. P., Camara, P. G.: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells using metric geometry. 30th Conference on Intelligent Systems for Molecular Biology (ISMB2022) 2022 Notes: Abstract selected for a poster presentation by Kiya Govek at ISMB2022, July 10-14, 2022, Madison, WI.

Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo MV, Epstein DJ, Camara PG: Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation. Cell Reports 41(10): 111768, 2022 Notes: doi: 10.1016/j.celrep.2022.111768.

Aubin, R.*, Troisi, E. C.*, Montelongo, J., Alghalith, A. N., Nasrallah, M. P., Santi, M., Camara, P. G.: Pro-Inflammatory Cytokines Mediate the Epithelial-to-Mesenchymal-Like Transition of Pediatric Posterior Fossa Ependymoma. Nature Communications 13: 3936, 2022.