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Tristan Hayeck, PhD
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Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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Contact information
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Abramson Research Bldg. 710B
2f The Children's Hospital of Philadelphia
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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2f The Children's Hospital of Philadelphia
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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Office: 267-426-7588
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Education:
21 9 B.S. 23 (Mechanical Engineering) c
3e Massachusetts Institute of Technology, 2006.
21 9 M.S. 1b (Biostatistics,) c
43 Harvard T. H. Chan School of Public Health, 2012.
21 a Ph.D. 1a (Biostatistics) c
43 Harvard T. H. Chan School of Public Health, 2015.
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Permanent link21 9 B.S. 23 (Mechanical Engineering) c
3e Massachusetts Institute of Technology, 2006.
21 9 M.S. 1b (Biostatistics,) c
43 Harvard T. H. Chan School of Public Health, 2012.
21 a Ph.D. 1a (Biostatistics) c
43 Harvard T. H. Chan School of Public Health, 2015.
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14a Duan Y, Stavrianidis C, Shaw GT wen, Sottolano C, Rajagopalan R, Jadhav T, Rhodes GE, Hayeck TJ, Allen AS: Functional Category-Specific Intolerance Reflects Genic Function and Clinical Relevance. http://biorxiv.org/lookup/doi/10.1101/2025.09.24.678298 2025.
18b Hu T, Mosbruger TL, Tairis NG, Dinou A, Jayaraman P, Sarmady M, Brewster K, Li Y, Hayeck TJ, Duke JL, Monos DS.: Targeted and complete genomic sequencing of the major histocompatibility complex in haplotypic form of individual heterozygous samples. Genome Res 34(10): 1500-1513, Oct 2024 Notes: doi: 10.1101/gr.278588.123.
175 Askar, Medhat, Timothy L Mosbruger, Grace Tzun-wen Shaw, Haedong Kim, Yuncheng Duan, Andrew S Allen, Jamie L Duke, Timothy S Olson, Dimitri S Monos, and Tristan J Hayeck.: Machine Learning Insights into HLA Noncoding Sequence Mismatches and Their Impact on DPB1 Matching in Hematopoietic Cell Transplantation. MedRxiv 57 Sept 2024 Notes: doi: https://doi.org/10.1101/2024.09.13.24313580.
1e7 Gilbert MA, Keefer-Jacques E, Jadhav T, Antfolk D, Ming Q, Valente N, Shaw GT, Sottolano CJ, Matwijec G, Luca VC, Loomes KM, Rajagopalan R, Hayeck TJ, Spinner NB.: Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation. Am J Hum Genet 8(111): 1656-1672, Aug 2024 Notes: https://pubmed.ncbi.nlm.nih.gov/39327030/
1d1 Hayeck, T. J., Li, Y., Mosbruger, T. L., Bradfield, J. P., Gleason, A. G., Damianos, G., Shaw, G. T.-W., Duke, J. L., Conlin, J. L., Turner, T. N., Fernández-Viña, M. A., Sarmady, M., & Monos, D. S.: The Impact of Patterns in Linkage Disequilibrium and Sequencing Quality on the Imprint of Balancing Selection. Genome Biology and Evolution 1;16(2), Feb 2024 Notes: doi: 10.1093/gbe/evae009.
14b Tristan Hayeck: Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry Podcast. https://www.myadlm.org/science-and-research/clinical-chemistry/clinical-chemistry-podcasts/2023/polygenic-risk-scores_genomes-to-risk-prediction (eds.). June 2023.
1cd Margolis DJ, Duke JL, Mitra N, Berna RA, Hoffstad OJ, Wasserman JR, Dinou A, Damianos G, Kotsopoulou I, Tairis N, Ferriola DA, Mosbruger TL, Hayeck TJ, Yan AC, Monos DS: A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis. Front Genet. 23(14), Jan 2023 Notes: 1004138. doi: 10.3389/fgene.2023. 2 14
11d Hayeck TJ, Busby GB, Chun Sung, Lewis ACF, Roberts MC, BJ Vilhjálmsson: Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry 69(6): 551-557, 2023 Notes: https://doi.org/10.1093/clinchem/hvad049.
173 Hayeck, T.J., Stong, N., Baugh, E., Dhindsa, R., Turner, T.N., Malakar, A., Mosbruger, T.L., Duan, Y., Ionita-Laza, I., Goldstein, D. and Allen, A.S: Ancestry adjustment improves genome-wide estimates of regional intolerance. Genetics 221(2): iyac050, Apr 2022 Notes: doi: 10.1093/genetics/iyac050.
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Selected Publications
193 Mosbruger TL, Dinou A, Duke JL, Ferriola D, Li Y, Hayeck TJ, Monos DS.: Haplotypic resolution of the challenging genomic regions of MHC and KIR using a combination of targeted sequencing and a novel assembly pipeline. Nucleic Acids Res 53(10), May 2025 Notes: https://academic.oup.com/nar/article/doi/10.1093/nar/gkaf441/8156621.14a Duan Y, Stavrianidis C, Shaw GT wen, Sottolano C, Rajagopalan R, Jadhav T, Rhodes GE, Hayeck TJ, Allen AS: Functional Category-Specific Intolerance Reflects Genic Function and Clinical Relevance. http://biorxiv.org/lookup/doi/10.1101/2025.09.24.678298 2025.
18b Hu T, Mosbruger TL, Tairis NG, Dinou A, Jayaraman P, Sarmady M, Brewster K, Li Y, Hayeck TJ, Duke JL, Monos DS.: Targeted and complete genomic sequencing of the major histocompatibility complex in haplotypic form of individual heterozygous samples. Genome Res 34(10): 1500-1513, Oct 2024 Notes: doi: 10.1101/gr.278588.123.
175 Askar, Medhat, Timothy L Mosbruger, Grace Tzun-wen Shaw, Haedong Kim, Yuncheng Duan, Andrew S Allen, Jamie L Duke, Timothy S Olson, Dimitri S Monos, and Tristan J Hayeck.: Machine Learning Insights into HLA Noncoding Sequence Mismatches and Their Impact on DPB1 Matching in Hematopoietic Cell Transplantation. MedRxiv 57 Sept 2024 Notes: doi: https://doi.org/10.1101/2024.09.13.24313580.
1e7 Gilbert MA, Keefer-Jacques E, Jadhav T, Antfolk D, Ming Q, Valente N, Shaw GT, Sottolano CJ, Matwijec G, Luca VC, Loomes KM, Rajagopalan R, Hayeck TJ, Spinner NB.: Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation. Am J Hum Genet 8(111): 1656-1672, Aug 2024 Notes: https://pubmed.ncbi.nlm.nih.gov/39327030/
1d1 Hayeck, T. J., Li, Y., Mosbruger, T. L., Bradfield, J. P., Gleason, A. G., Damianos, G., Shaw, G. T.-W., Duke, J. L., Conlin, J. L., Turner, T. N., Fernández-Viña, M. A., Sarmady, M., & Monos, D. S.: The Impact of Patterns in Linkage Disequilibrium and Sequencing Quality on the Imprint of Balancing Selection. Genome Biology and Evolution 1;16(2), Feb 2024 Notes: doi: 10.1093/gbe/evae009.
14b Tristan Hayeck: Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry Podcast. https://www.myadlm.org/science-and-research/clinical-chemistry/clinical-chemistry-podcasts/2023/polygenic-risk-scores_genomes-to-risk-prediction (eds.). June 2023.
1cd Margolis DJ, Duke JL, Mitra N, Berna RA, Hoffstad OJ, Wasserman JR, Dinou A, Damianos G, Kotsopoulou I, Tairis N, Ferriola DA, Mosbruger TL, Hayeck TJ, Yan AC, Monos DS: A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis. Front Genet. 23(14), Jan 2023 Notes: 1004138. doi: 10.3389/fgene.2023. 2 14
11d Hayeck TJ, Busby GB, Chun Sung, Lewis ACF, Roberts MC, BJ Vilhjálmsson: Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry 69(6): 551-557, 2023 Notes: https://doi.org/10.1093/clinchem/hvad049.
173 Hayeck, T.J., Stong, N., Baugh, E., Dhindsa, R., Turner, T.N., Malakar, A., Mosbruger, T.L., Duan, Y., Ionita-Laza, I., Goldstein, D. and Allen, A.S: Ancestry adjustment improves genome-wide estimates of regional intolerance. Genetics 221(2): iyac050, Apr 2022 Notes: doi: 10.1093/genetics/iyac050.
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