Matthew Tudor
Adjunct Assistant Professor of Cell and Developmental Biology
Department: Cell and Developmental Biology
Contact information
Screening & Protein Sciences
Merck Research Laboratories, NW-1
502 Louise Lane
North Wales, PA 19454
Merck Research Laboratories, NW-1
502 Louise Lane
North Wales, PA 19454
Office: 267-305-1517
Fax: 267-305-3625
Fax: 267-305-3625
Education:
B.S. (Biology, With Honors)
Cornell University, 1995.
Ph.D. (Biology (Advisors: Rudolf Jaenish, Rick Young))
Massachusetts Institute of Technology, 2004.
Permanent linkB.S. (Biology, With Honors)
Cornell University, 1995.
Ph.D. (Biology (Advisors: Rudolf Jaenish, Rick Young))
Massachusetts Institute of Technology, 2004.
Description of Research Expertise
High throughput liquid handling and cell-based assay technologies, laboratory automation, small molecule and genetic screening, high content assay development and analysis, high throughput expression profiling, combinatorial screening, flow cytometry, microscopy, molecular biology, biochemistry, transgenic mouse generation and phenotyping, microarray technologiesSelected Publications
Coyne, C.B., Bozym, R., Morosky, S.A., Hanna, S.L., Mukherjee, A., Tudor, M., Kim, K.S., Cherry S.: RNAi screening reveals host factors involved in enteroviruses infection of polarized endothelial monolayers. Cell Host Microbe 9: 70-82, 2010.Tudor, M., Akbarian, S., Chen, R. Z. & Jaenisch, R.: Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A 99: 15536-41, 2002.
Chen, Z.H., Akbarian, S., Tudor, M., Jaenisch, R.: Deficiency of methyl-CpG binding protein 2 (MeCP2) in CNS neurons results in a Rett-like phenotype in mice, Nat Genet Nat Genet 27: 327-31, 2001.
Wilson C.J., Guglielmo C., Moua N.D., Tudor M., Grosveld G., Young R.A., Murray P.J: Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. Anal Biochem 296: 270-8, 2001.
Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., and Jaenisch, R.: Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 27: 31-9, 2001.
Tudor, M., Murray, P. J., Onufryk, C., Jaenisch, R., and Young, R. A.: Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev 13: 2365-8, 1999.
Takenaka, T., Hendrickson, C. S., Tworek, D. M., Tudor, M., Schiffmann, R., Brady, R. O., and Medin, J. A.: Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. Exp Hematol 27: 1149-59, 1999.
Lyko, F., Ramsahoye, B. H., Kashevsky, H., Tudor, M., Mastrangelo, M. A., Orr-Weaver, T. L., and Jaenisch, R.: Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat Gen 23: 363-6, 1999.
Fan H.Y., Hu Y., Tudor M., Ma H.: Specific interactions between the K domains of AG and AGLs, members of the MADS domain family of DNA binding proteins. Plant J 12: 999-1010, 1997.
Mizukami Y., Huang H., Tudor M., Hu Y., Ma H.: Functional domains of the floral regulator AGAMOUS: characterization of the DNA binding domain and analysis of dominant negative mutations. Plant Cell 8: 831-45, 1996.