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Corey T McMillan, PhD

Associate Professor of Neurology
Member, University of Pennsylvania, Institute for Translational Medicine & Therapeutics
Member, University of Pennsylvania, Center for Functional Neuroimaging
Member, University of Pennsylvania, Penn Neurodegeneration Genomics Center
Member, University of Pennsylvania, MindCORE
Fellow, University of Pennsylvania, Institute on Aging, Division of Clinical and Translational Neurodegenerative Disease Research
Research Director, University of Pennsylvania, Penn Frontotemporal Degeneration Center
Senior Fellow, University of Pennsylvania, Institute for Biomedical Informatics
Department: Neurology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Neurology
3400 Spruce Street
3 West Gates
Philadelphia, PA 19104
Office: 215 614 0987
Fax: 215 349 8464
Lab: 215 349 5863
Graduate Group Affiliations
BA (Psychology & Cognitive Neuroscience)
Temple University, 2000.
MSc (Psycholinguistics)
University of Edinburgh, 2004.
PhD (Psychology)
University of Edinburgh, 2008.
Post-Graduate Training
IGERT Postdoctoral Fellow, University of Pennsylvania, Institute for Research in Cognitive Science, 2008-2009.
NRSA Postdoctoral Fellow, University of Pennsylvania, Department of Neurology, 2009-2012.
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Description of Research Expertise

Research Interests:
The overall mission of my integrative neuroscience lab is to use multimodal and bioinformatic approaches to improve our understanding of the biological basis of neurodegenerative conditions. My lab aims to develop robust biomarkers that can be used to better diagnose neurodegenerative diseases, accelerate drug discovery of disease-modifying agents, and to define essential clinical trial endpoint measures. My clinical-translation research program focuses on two classes of neurodegenerative proteinopathies including the misfolded tau protein that contributes to Alzheimer’s disease (AD), primary age-related tauopathy (PART), and frontotemporal lobar degeneration (FTLD), as well as the TDP-43 protein that contributes to a spectrum of FTLD and amyotrophic lateral sclerosis (ALS). My lab emphasizes biologically-grounded hypotheses with novel analytic and multimodal approaches integrating MRI and PET imaging modalities with genomics and clinical datasets.

neurodegeneration, neuroimaging, biomarkers, frontotemporal degeneration (FTD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS).

Rotation Projects:
Typical projects involve analysis of neuroimaging datasets to address clinical translation questions (e.g., Can diffusion tensor imaging identify underlying sources of pathology in neurodegenerative disease patients?) or basic science questions (e.g., How is a genetic polymorphism related to neuroanatomical structure?).

Lab Personnel:
All lab personnel are members of the Penn Frontotemporal Degeneration Center (FTDC).

Selected Publications

McMillan, C. T., Avants, B. B., Cook, P., Ungar, L., Trojanowksi, J. Q., & Grossman, M.: The power of neuroimaging biomarkers for screening frontotemporal dementia. Human Brain Mapping 35(9): 4827-4840, 2014.

McMillan, C. T., Toledo, J., Avants, B., Cook, P., Wood, E. M., Suh, E., Irwin, D. J., Powers, J., Olm, C., Elman, L., McCluskey, L., Schellenberg, G., Lee, V. M.-Y., Trojanowksi, J. Q., Van Deerlin, V. M., & Grossman, M. : Genetic & neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of Aging 35(6): 1473-1482, 2014.

McMillan, C. T., Irwin, D. J., Avants, B. B., Powers, J, Cook, P. A., Toledo, J. B., Wood, E. M., Van Deerlin, V. M., Lee, V. M.-Y., Trojanowksi, J. Q., & Grossman, M.: White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry 84(9): 949-955, 2013.

McMillan, C. T., Avants, B., Irwin, D. J., Toledo, J. B., Wolk, D. A., Van Deerlin, V. M., Shaw, L. M., Trojanowksi, J Q., & Grossman, M.: Can MRI screen for cerebrospinal fluid biomarkers in neurodegenerative disease? Neurology 80(2): 132-138, 2013.

McMillan C. T., Brun, C., Siddiqui, S., Churgin, M., Yuskevich, P., Zhang, H., Libon, D., Gee, J., & Grossman, M. : White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration. Neurology 78(22): 1761-1768, 2012.

Cook, P. A., McMillan, C. T., Avants, B. B., Peelle, J. E., Gee, J. C., & Grossman, M. : Relating brain anatomy and cognitive ability using a multivariate multimodal framework. NeuroImage 99: 477-486, 2014.

Russ, J., Liu, E.Y., Wu, K., Neal, D., Suh, E., Irwin, D. J., McMillan, C. T., Harms, M. B., Cairns, N. J., Wood, E. M., Xie, S. X., Elman, L., McCluskey, L., Grossman, M., Van Deerlin V. M., & Lee, E. B.: Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta Neuropathologica 129(1): 39-52, 2015.

Irwin, D. J., McMillan, C. T., Brettschneider, J., Libon, D. J., Powers, J., Rascovsky, K., Toledo, J. B., Boller, A., Bekisz, J., Chandrasekaren, K., Wood, E. M., Shaw, L., Woo, J. H., Cook, P. A., Wolk, D. A., Arnold, S. E., Van Deerlin, V. M., McCluskey, L. F., Elman, L., Lee, V. M.-Y., Trojanowski, J. Q., & Grossman, M.: Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 84(2): 163-169, 2013.

Irwin, D., McMillan, C. T., Toledo, J. B., Arnold, S. E., Shaw, L. M., Wang, L.-S., Lee, V.-Y., Trojanowski, J. Q., & Grossman, M.: Comparison of cerebrospinal fluid levels of tau and Abeta1-42 in Alzheimer's disease and frontotemporal degeneration using two analytical platforms. Archives of Neurology 69(8): 1018-1025, 2012.

Irwin, D. J., McMillan, C. T., Suh, E., Powers, J., Rascovsky, K., Wood, E. M., Toledo, J. B., Arnold, S. E., Lee, V. M., Van Deerlin, V. M., Trojanowski, J. Q., & Grossman, M.: Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology 83(6): 502-509, 2014.

McMillan, C. T., Rascovsky, K., Khella, M. C., Clark, R., & Grossman, M.: The neural basis of establishing a focal point in pure coordination games. Social, Cognitive, & Affective Neuroscience 7(8): 881-887, 2012.

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Last updated: 01/22/2024
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