Daniel J. Licht, MD
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
New York University, 1984.
New Jersey Medical School - UMDNJ, 1997.
House officer, The Children's Hospital of Philadelphia, 1997-1999.
Neurology fellow, Hospital of the University of Pennsylvania, The Children's Hospital of Philadelphia, 1999-2002.
Epilepsy and Critical Care Fellowship, The Children's Hospital of Philadelphia, 2002-2004.
The American Board of Pediatrics, 2002.
The American Board of Psychiatry and Neurology, 2003.
ABPN recertification, 2013.
Description of Research ExpertiseI am a child neurologist with expertise in the care of the critically ill infants and children. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.
As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.
Description of Clinical ExpertiseMy clinical expertise is in the neurological care for children who are critically ill infants and children. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.
My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.
Selected PublicationsBusch David R, Baker Wesley B, Mavroudis Constantine D, Ko Tiffany S, Lynch Jennifer M, McCarthy Ann L, Du Pont-Thibodeau Genevieve, Buckley Erin M, Jacobwitz Marin, Boorady Timothy, Mensah-Brown Kobina, Connelly James, Yodh Arjun G, Kilbaugh Todd J, Licht Daniel J: Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient. Pediatric research Mar 2020.
Thibault Céline, Naim Maryam Y, Abend Nicholas S, Licht Daniel J, Gaynor J William, Xiao Rui, Massey Shavonne L: A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. Epilepsia Mar 2020.
Porcari Giulia S, Jordan Lori C, Ichord Rebecca N, Licht Daniel J, Smith Sabrina E, Beslow Lauren A: Outcome Trajectories after Primary Perinatal Hemorrhagic Stroke. Pediatric neurology 105: 41-47, Dec 2019.
White Brian R, Padawer-Curry Jonah A, Cohen Akiva S, Licht Daniel J, Yodh Arjun G: Brain segmentation, spatial censoring, and averaging techniques for optical functional connectivity imaging in mice. Biomedical optics express 10(11): 5952-5973, Nov 2019.
McGovern Patrick E, Lawrence Kendall, Baumgarten Heron, Rossidis Avery, Mejaddam Ali, Licht Daniel J, Grinspan Judith, Schupper Alexander, Rychik Jack, Didier Ryne A, Vossough Arastoo, Spray Thomas L, Peranteau William H, Davey Marcus G, Flake Alan W, Gaynor J William: EX-UTERO EXTRACORPOREAL SUPPORT AS A MODEL FOR FETAL HYPOXIA AND BRAIN DYSMATURITY. The Annals of thoracic surgery 109(3): 810-819, Sep 2019.
Massey Shavonne L, Abend Nicholas S, Gaynor J William, Licht Daniel J, Nadkarni Vinay M, Topjian Alexis A, Xiao Rui, Naim Maryam Y: Electroencephalographic Patterns Preceding Cardiac Arrest in Neonates Following Cardiac Surgery. Resuscitation 144: 67-74, Sep 2019.
Lawrence Kendall M, McGovern Patrick E, Mejaddam Ali, Rossidis Avery C, Baumgarten Heron, Kim Aimee G, Grinspan Judith B, Licht Daniel J, Radaelli Enrico, Rychik Jack, Peranteau William H, Davey Marcus G, Flake Alan W, Gaynor J William: Prenatal hypoxemia alters microglial morphology in fetal sheep. The Journal of thoracic and cardiovascular surgery Aug 2019.
Geocadin Romergryko G, Callaway Clifton W, Fink Ericka L, Golan Eyal, Greer David M, Ko Nerissa U, Lang Eddy, Licht Daniel J, Marino Bradley S, McNair Norma D, Peberdy Mary Ann, Perman Sarah M, Sims Daniel B, Soar Jasmeet, Sandroni Claudio: Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 140(9): CIR0000000000000702, Jul 2019.
Lautz Andrew J, Morgan Ryan W, Karlsson Michael, Mavroudis Constantine D, Ko Tiffany S, Licht Daniel J, Nadkarni Vinay M, Berg Robert A, Sutton Robert M, Kilbaugh Todd J: Hemodynamic-Directed Cardiopulmonary Resuscitation Improves Neurologic Outcomes and Mitochondrial Function in the Heart and Brain. Critical care medicine 47(3): e241-e249, Mar 2019.
Lawrence Kendall M, McGovern Patrick E, Mejaddam Ali, Rossidis Avery C, Baumgarten Heron, Kim Aimee, Grinspan Judith B, Licht Daniel J, Didier Ryne A, Vossough Arastoo, Radaelli Enrico, Rychik Jack, Song Limei, Peranteau William H, Davey Marcus G, Flake Alan W, Gaynor J William: Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep. The Journal of thoracic and cardiovascular surgery 157(5): 1982-1991, Jan 2019.