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Daniel J. Licht, MD

Associate Professor of Neurology at the Children's Hospital of Philadelphia
Attending, Neurology ICU Consults, Children's Hospital, Philadelphia
Attending, PACT consults (Palliative Care), Children's Hospital, Philadelphia
Attending, Neuro-Cardiac Care Program, Children's Hospital, Philadelphia
Attending, Fetal Neurology Consults, Children's Hospital, Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
Post-Graduate Training
House officer, The Children's Hospital of Philadelphia, 1997-1999.
Neurology fellow, Hospital of the University of Pennsylvania, The Children's Hospital of Philadelphia, 1999-2002.
Epilepsy and Critical Care Fellowship, The Children's Hospital of Philadelphia, 2002-2004.
The American Board of Pediatrics, 2002.
The American Board of Psychiatry and Neurology, 2003.
ABPN recertification, 2013.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Clinical Expertise

My clinical expertise is in the neurological care for children who are critically ill. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.

As a consequence of caring for critically ill children, I am also a palliative care provider and attending on the Pediatric Advanced Care Team at CHOP. The PACT team is a multidisciplinary palliative care team with a directive to provide symptom relief at the end of life, with a goal of achieving the best quality of life in the face of terminal illness.

My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.

Selected Publications

Jalali Ali, Simpao Allan F, Gálvez Jorge A, Licht Daniel J, Nataraj Chandrasekhar: Prediction of Periventricular Leukomalacia in Neonates after Cardiac Surgery Using Machine Learning Algorithms. Journal of medical systems 42(10): 177, Aug 2018.

Mavroudis Constantine D, Mensah-Brown Kobina G, Ko Tiffany S, Boorady Timothy W, Massey Shavonne L, Abend Nicholas S, Nicolson Susan C, Morgan Ryan W, Mascio Christopher E, Gaynor J William, Kilbaugh Todd J, Licht Daniel J: Electroencephalographic Response to Deep Hypothermic Circulatory Arrest in Neonatal Swine and Humans. The Annals of thoracic surgery Jul 2018.

Porcari Giulia S, Beslow Lauren A, Ichord Rebecca N, Licht Daniel J, Kleinman Jonathan T, Jordan Lori C: Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage: A Prospective Study. Stroke 49(7): 1755-1758, Jun 2018 Notes: epub ahead of print.

Lynch Jennifer M, Ko Tiffany, Busch David R, Newland John J, Winters Madeline E, Mensah-Brown Kobina, Boorady Timothy W, Xiao Rui, Nicolson Susan C, Montenegro Lisa M, Gaynor J William, Spray Thomas L, Yodh Arjun G, Naim Maryam Y, Licht Daniel J: Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease. The Journal of thoracic and cardiovascular surgery May 2018 Notes: epub ahead of print.

Rychik Jack, Goff Donna, McKay Eileen, Mott Antonio, Tian Zhiyun, Licht Daniel J, Gaynor J William: Characterization of the Placenta in the Newborn with Congenital Heart Disease: Distinctions Based on Type of Cardiac Malformation. Pediatric cardiology 39(6): 1165-1171, May 2018 Notes: epub ahead of print.

Gaynor J William, Nicolson Susan C, Spray Diane M, Burnham Nancy B, Chittams Jesse L, Sammarco Therese, Walsh Kevin W, Spray Thomas L, Licht Daniel J: Remote Ischemic Preconditioning does not Prevent White Matter Injury in Neonates. The Annals of thoracic surgery 106(1): 151-155, Mar 2018.

Grasty Madison A, Ittenbach Richard F, Knightly Carol, Solot Cynthia B, Gerdes Marsha, Bernbaum Judy C, Wernovsky Gil, Spray Thomas L, Nicolson Susan C, Clancy Robert R, Licht Daniel J, Zackai Elaine, Gaynor J William, Burnham Nancy B: Hearing Loss after Cardiac Surgery in Infancy: An Unintended Consequence of Life-Saving Care. The Journal of pediatrics 192(1): 144-151.e1, Jan 2018.

Mavroudis Constantine D, Karlsson Michael, Ko Tiffany, Hefti Marco, Gentile Javier I, Morgan Ryan W, Plyler Ross, Mensah-Brown Kobina G, Boorady Timothy W, Melchior Richard W, Rosenthal Tami M, Shade Brandon C, Schiavo Kellie L, Nicolson Susan C, Spray Thomas L, Sutton Robert M, Berg Robert A, Licht Daniel J, Gaynor J William, Kilbaugh Todd J: Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 54(1): 162-168, Jan 2018.

Szwast Anita, Putt Mary, Gaynor J William, Licht Daniel, Rychik Jack: Cerebrovascular Response to Maternal Hyperoxygenation (MH) in Fetuses with Hypoplastic Left Heart Syndrome (HLHS) Depends Upon Gestational Age (GA) and Baseline Cerebrovascular Resistance. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Oct 2017 Notes: epub ahead of print.

Antiel Ryan M, Lin Nan, Licht Daniel J, Hoffman Casey, Waqar Lindsay, Xiao Rui, Monos Stylianos, D'Agostino Jo Ann, Bernbaum Judy, Herkert Lisa M, Rintoul Natalie E, Peranteau William H, Flake Alan W, Adzick N Scott, Hedrick Holly L: Growth trajectory and neurodevelopmental outcome in infants with congenital diaphragmatic hernia. Journal of pediatric surgery 52(12): 1944-1948, Sep 2017.

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Last updated: 10/18/2018
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