Daniel J. Licht

faculty photo
Associate Professor of Neurology at the Children's Hospital of Philadelphia
Attending, Neurology ICU Consults, Children's Hospital, Philadelphia
Attending, PACT consults (Palliative Care), Children's Hospital, Philadelphia
Attending, Neuro-Cardiac Care Program, Children's Hospital, Philadelphia
Attending, Fetal Neurology Consults, Children's Hospital, Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Itmat Expertise

Dr. Licht is a pediatric neurologist who is interested in implementing innovative, non-invasive neuro-imaging techniques for clinical use. Current research involves the study of the influence of congenital heart defects on fetal brain development.

Selected Publications

Grasty Madison A, Ittenbach Richard F, Knightly Carol, Solot Cynthia B, Gerdes Marsha, Bernbaum Judy C, Wernovsky Gil, Spray Thomas L, Nicolson Susan C, Clancy Robert R, Licht Daniel J, Zackai Elaine, Gaynor J William, Burnham Nancy B: Hearing Loss after Cardiac Surgery in Infancy: An Unintended Consequence of Life-Saving Care. The Journal of pediatrics 192: 144-151.e1, Jan 2018.

Szwast Anita, Putt Mary, Gaynor J William, Licht Daniel, Rychik Jack: Cerebrovascular Response to Maternal Hyperoxygenation (MH) in Fetuses with Hypoplastic Left Heart Syndrome (HLHS) Depends Upon Gestational Age (GA) and Baseline Cerebrovascular Resistance. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Oct 2017.

Antiel Ryan M, Lin Nan, Licht Daniel J, Hoffman Casey, Waqar Lindsay, Xiao Rui, Monos Stylianos, D'Agostino Jo Ann, Bernbaum Judy, Herkert Lisa M, Rintoul Natalie E, Peranteau William H, Flake Alan W, Adzick N Scott, Hedrick Holly L: Growth trajectory and neurodevelopmental outcome in infants with congenital diaphragmatic hernia. Journal of pediatric surgery 52(12): 1944-1948, Sep 2017.

Smith Brendan, Vu Eric, Kibler Kathleen, Rusin Craig, Easley Ronald B, Andropoulos Dean, Heinle Jeffrey, Czosnyka Marek, Licht Daniel, Lynch Jennifer, Brady Ken: Does hypothermia impair cerebrovascular autoregulation in neonates during cardiopulmonary bypass? Paediatric anaesthesia 27(9): 905-910, Jun 2017.

Baker Wesley B, Parthasarathy Ashwin B, Gannon Kimberly P, Kavuri Venkaiah C, Busch David R, Abramson Kenneth, He Lian, Mesquita Rickson C, Mullen Michael T, Detre John A, Greenberg Joel H, Licht Daniel J, Balu Ramani, Kofke W Andrew, Yodh Arjun G: Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37(8): 271678X17709166, Jan 2017.

Billinghurst Lori L, Beslow Lauren A, Abend Nicholas S, Uohara Michael, Jastrzab Laura, Licht Daniel J, Ichord Rebecca N: Incidence and predictors of epilepsy after pediatric arterial ischemic stroke. Neurology 88(7): 630-637, Jan 2017.

Lin Jainn-Jim, Banwell Brenda L, Berg Robert A, Dlugos Dennis J, Ichord Rebecca N, Kilbaugh Todd J, Kirsch Roxanne E, Kirschen Matthew P, Licht Daniel J, Massey Shavonne L, Naim Maryam Y, Rintoul Natalie E, Topjian Alexis A, Abend Nicholas S: Electrographic Seizures in Children and Neonates Undergoing Extracorporeal Membrane Oxygenation. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 18(3): 249-257, Jan 2017.

Uohara Michael Y, Beslow Lauren A, Billinghurst Lori, Jones Brianna M, Kessler Sudha K, Licht Daniel J, Ichord Rebecca N: Incidence of Recurrence in Posterior Circulation Childhood Arterial Ischemic Stroke. JAMA neurology 74(3): 316-323, Jan 2017.

Fogel Mark A, Li Christine J, Elci Okan U, Pawlowski Tom, Schwab Peter J, Wilson Felice B, Nicolson Susan C, Montenegro Lisa M, Diaz Laura, Spray Thomas L, Gaynor J William, Fuller Stephanie, Mascio Christopher E, Keller Marc S, Harris Matthew A, Whitehead Kevin K, Bethel James, Vossough Arastoo, Licht Daniel J: Neurologic Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction. Circulation 135(7): 671-682, Dec 2016.

Ouyang Minhui, Liu Peiying, Jeon Tina, Chalak Lina, Heyne Roy, Rollins Nancy K, Licht Daniel J, Detre John A, Roberts Timothy P L, Lu Hanzhang, Huang Hao: Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. NeuroImage 147: 233-242, Dec 2016.

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Last updated: 12/19/2017
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