Daniel J. Licht

faculty photo
Associate Professor of Neurology at the Children's Hospital of Philadelphia
Attending, Neurology ICU Consults, Children's Hospital, Philadelphia
Attending, PACT consults (Palliative Care), Children's Hospital, Philadelphia
Attending, Neuro-Cardiac Care Program, Children's Hospital, Philadelphia
Attending, Fetal Neurology Consults, Children's Hospital, Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Itmat Expertise

Dr. Licht is a pediatric neurologist who is interested in implementing innovative, non-invasive neuro-imaging techniques for clinical use. Current research involves the study of the influence of congenital heart defects on fetal brain development.

Selected Publications

Jalali Ali, Jones Gerard F, Licht Daniel J, Nataraj C: Application of Mathematical Modeling for Simulation and Analysis of Hypoplastic Left Heart Syndrome (HLHS) in Pre- and Postsurgery Conditions. BioMed research international 2015: 987293, Oct 2015.

Busch David R, Lynch Jennifer M, Winters Madeline E, McCarthy Ann L, Newland John J, Ko Tiffany, Cornaglia Mary Anne, Radcliffe Jerilynn, McDonough Joseph M, Samuel John, Matthews Edward, Xiao Rui, Yodh Arjun G, Marcus Carole L, Licht Daniel J, Tapia Ignacio E: Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome. Sleep 39(1): 209-16, Aug 2015.

Fogel Mark A, Li Christine, Wilson Felice, Pawlowski Tom, Nicolson Susan C, Montenegro Lisa M, Diaz Berenstein Laura, Spray Thomas L, Gaynor J William, Fuller Stephanie, Keller Marc S, Harris Matthew A, Whitehead Kevin K, Clancy Robert, Elci Okan, Bethel Jim, Vossough Arastoo, Licht Daniel J: Relationship of cerebral blood flow to aortic-to-pulmonary collateral/shunt flow in single ventricles. Heart (British Cardiac Society) 101(16): 1325-31, Jun 2015.

Wu J, Awate S P, Licht D J, Clouchoux C, du Plessis A J, Avants B B, Vossough A, Gee J C, Limperopoulos C: Assessment of MRI-Based Automated Fetal Cerebral Cortical Folding Measures in Prediction of Gestational Age in the Third Trimester. AJNR. American journal of neuroradiology 36(7): 1369-74, Jun 2015.

McCarthy Ann L, Winters Madeline E, Busch David R, Gonzalez-Giraldo Ernesto, Ko Tiffany S, Lynch Jennifer M, Schwab Peter J, Xiao Rui, Buckley Erin M, Vossough Arastoo, Licht Daniel J: Scoring System for Periventricular Leukomalacia in Infants with Congenital Heart Disease. Pediatric research 78(3): 304-9, May 2015 Notes: We developed and validated an observational scale for rating white matter injury in this population of infants with severe congenital heart surgery. This is a first step for a multicenter collaborative trial.

Starling Rebecca M, Shekdar Karuna, Licht Dan, Nadkarni Vinay M, Berg Robert A, Topjian Alexis A: Early Head CT Findings Are Associated With Outcomes After Pediatric Out-of-Hospital Cardiac Arrest. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 16(6): 542-8, Apr 2015.

Naim Maryam Y, Gaynor J William, Chen Jodi, Nicolson Susan C, Fuller Stephanie, Spray Thomas L, Dlugos Dennis J, Clancy Robert R, Costa Livia Vianez, Licht Daniel J, Xiao Rui, Meldrum Heather, Abend Nicholas S: Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. The Journal of thoracic and cardiovascular surgery 150(1): 169-80, Apr 2015.

Sinclair Adriane J, Fox Christine K, Ichord Rebecca N, Almond Christopher S, Bernard Timothy J, Beslow Lauren A, Chan Anthony K C, Cheung Michael, deVeber Gabrielle, Dowling Michael M, Friedman Neil, Giglia Therese M, Guilliams Kristin P, Humpl Tilman, Licht Daniel J, Mackay Mark T, Jordan Lori C: Stroke in Children With Cardiac Disease: Report From the International Pediatric Stroke Study Group Symposium. Pediatric neurology 52(1): 5-15, Jan 2015.

Peart Jenna M, Licht Daniel J, Prange Erin O'Connor, Treat James R: Intractable Nodulocystic Acne in a Patient with Trisomy 13. Pediatric dermatology 32(3): 381-2, Jan 2015.

Sultan Sally M, Beslow Lauren A, Vossough Arastoo, Elkind Mitchell S V, Kasner Scott E, Mirsky David M, Licht Daniel J, Ichord Rebecca N: Predictive validity of severity grading for cerebral steno-occlusive arteriopathy in recurrent childhood ischemic stroke. International journal of stroke : official journal of the International Stroke Society 10(2): 213-8, Aug 2014.

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Last updated: 04/26/2016
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