Laura Joan Balcer, M.D., M.S.C.E.
240 E. 38th Street, 20th Floor ACC
New York, NY 10016
Dulaney High School, 1983.
College of William and Mary, 1987.
The Johns Hopkins University School of Medicine, 1991.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania School of Medicine, 2000.
Intern in Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1991-1992.
Resident in Neurology, Hospital of the University of Pennsylvania, Philadelphia, 1992-1995.
Fellowship, Neuro-Ophthalmology, Hospital of the University of Pennsylvania, Scheie Eye Institute, Philadelphia, 1995-1996.
American Board of Psychiatry and Neurology Certificate #42767, 2006.
Description of Research ExpertiseDr. Balcer’s primary research focus is on the identification and development of clinical visual outcome measures for multiple sclerosis (MS) trials. Dr. Balcer’s group, funded jointly by the National Eye Institute and the National MS Society, focuses on determining which clinical tests best identify visual dysfunction in patients with MS. These studies have also examined the relation of visual function to neurologic impairment, magnetic resonance imaging abnormalities, and health-related quality of life. Data from these and other investigations at U. Penn have led to the inclusion of low-contrast letter acuity as a secondary outcome measure in 2 international MS treatment trials. A new ocular imaging technique, optical coherence tomography (OCT), has been used to examine retinal nerve fiber layer and macular thickness as biologic markers of neuronal and axonal loss in patients with MS.
Description of Clinical ExpertiseNeuro-Ophthalmology; Neuro-Ophthalmologic features of multiple sclerosis (MS)
Selected PublicationsVentura RE, Galetta SL, Balcer LJ: The neuro-ophthalmology of head trauma. Lancet Neurol 13: 1006-1013, 2014.
Balcer LJ, Galetta SL: OCT and NMO: are there methods to our madness? J Neuro-Ophthalmol 33: 209-12, 2013.
Fisher M.J., Loguidice M., Gutman D.H., Listernick R., Ferner R.E., Ullrich N.J., Packer R.J., Tabori U., Hoffman R.O., Ardern-Holmes S.L., Hummel T.R., Hargrave D.R., Bouffet E., Charrow J., Bilaniuk L.T., Balcer L.J., Liu G.T. : Visual outcomes in children with neurofibromatosis type 1 - associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis. Neuro-Oncology 14: 790-797, 2012.
Balcer L.J., Galetta S.L., Polman C.H., Eggenberger E., Calabresi P.A., Zhang A., Scanlon J.V., Hyde R. : Low-contrast acuity measures visual improvement in phase 3 trial of natalizumab in relapsing MS. Journal of the Neurological Sciences 318: 119-124, 2012.
Moss H.E., McCluskey L., Elman L., Hoskins K., Talman L., Grossman M., Balcer L.J., Galetta S.L., Liu G.T. : Cross-sectional evaluation of clinical neuro-ophthalmic abnormalities in an amyotrophic lateral sclerosis population. Journal of the Neurological Sciences 314: 97-101, 2012.
Galetta K.M., Graves J., Talman L.S., Lile D.J., Frohman E.M., Calabresi P.A., Galetta S.L., Balcer L.J.: Visual pathway axonal loss in benign multiple sclerosis: a longitudinal study. Journal of Neuro-Ophthalmology 32: 116-123, 2012.
Davies E.C., Henderson S., Balcer L.J., Galetta S.L.: The King-Devick test and sleep deprivation: study in pre- and post-call neurology residents. Neurology 78: e103-106, 2012.
Walter S.D., Ishikawa H., Galetta K.M., Sakai R.E., Feller D.J., Wilson J.A., Maguire M.G., Galetta S.L., Frohman E.M., Calabresi P.A., Schuman J.S., Balcer L.J.: Ganglion cell loss in relation to visual disability in multiple sclerosis. Ophthalmology 119: 1250-1257, 2012.
Seigo M.A., Sotirchos E.S., Newsome S., Babiarz A., Eckstein C., Ford E., Oakley J.D., Syc S.B., Frohman T.C., Ratchford J.N., Balcer L.J., Frohman E.M., Calabresi P.A., Saidha S.: In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques. Journal of Neurology 2012.
Ontaneda D, LaRocca N, Coetzee T, Rudick R: NMSS MSFC Task Force. Revisiting the multiple sclerosis functional composite: proceedings from the National Multiple Sclerosis Society(NMSS) Task Force on Clinical Disability Measures. Mult Scler 18: 1074-80, 2012.