Joel H. Greenberg, Ph.D.
3450 Hamilton Walk
Philadelphia, PA 19104
B.Sc. (Engineering Physics)
University of Manitoba, 1968.
University of Pennsylvania, 1974.
Research Fellow, Imperial College of Science and Technology, London, England, 1968-1968.
Description of Research ExpertiseKEY WORDS
cerebral circulation, cerebral blood flow control, cerebral ischemia,
emission tomography, autoradiography
Optical imaging, laser Doppler flowmetry, autoradiography, emission tomography, near infrared spectroscopy
There remains intense interest in discovering novel neuroprotective therapies for use in acute cerebral ischemia. Most recent research efforts have focused on compounds designed to interfere with the cascade of deleterious events that occur in tissue during and in the minutes and hours following cerebral ischemia. Although many compounds have been investigated in our laboratory as well as in several other laboratories, to-date none have proven clinically useful in humans. Non-pharmacological treatment techniques such as hypothermia and hyperoxemia have also been proposed, but it remains to be seen how they transfer from laboratory to bedside. There are even studies suggesting that electrical stimulation of the cerebellar fastigial nucleus prior to ischemia, or the spinal cord weeks and months following the ischemic insult can reduce damage. More recently we have shown in the rat that functional stimulation of the forepaw or of the vagus nerve during cerebral ischemia are neuroprotective. Our laboratory has been investigating the mechanism by which such stimulation can reduce neuronal damage.
Sun Zhenghui, Baker Wesley, Hiraki Teruyuki, Greenberg Joel H: The effect of right vagus nerve stimulation on focal cerebral ischemia: an experimental study in the rat. Brain stimulation Feb 2011.
Luckl Janos, Baker Wesley, Sun Zheng-Hui, Durduran Turgut, Yodh Arjun G, Greenberg Joel H: The biological effect of contralateral forepaw stimulation in rat focal cerebral ischemia: a multispectral optical imaging study. Frontiers in neuroenergetics 2, 2010.
Zhou Chao, Shimazu Tomokazu, Durduran Turgut, Luckl Janos, Kimberg Daniel Y, Yu Guoqiang, Chen Xiao-Han, Detre John A, Yodh Arjun G, Greenberg Joel H: Acute functional recovery of cerebral blood flow after forebrain ischemia in rat. Journal of cerebral blood flow and metabolism. 28(7): 1275-84, Jul 2008.
Burnett Mark G, Shimazu Tomokazu, Szabados Tamas, Muramatsu Hiromi, Detre John A, Greenberg Joel H: Electrical forepaw stimulation during reversible forebrain ischemia decreases infarct volume. Stroke 37(5): 1327-31, May 2006.
Shimazu Tomokazu, Inoue Ikuo, Araki Nobuo, Asano Yoshio, Sawada Masahiko, Furuya Daisuke, Nagoya Harumitsu, Greenberg Joel H: A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke 36(2): 353-9, Feb 2005.
Ances B M, Greenberg J H, Detre J A: Effects of variations in interstimulus interval on activation-flow coupling response and somatosensory evoked potentials with forepaw stimulation in the rat. Journal of cerebral blood flow and metabolism. 20(2): 290-7, Feb 2000.
Takahashi K, Greenberg J H, Jackson P, Maclin K, Zhang J: Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism. 17(11): 1137-42, Nov 1997.
Uematsu D, Araki N, Greenberg J H, Sladky J, Reivich M: Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurology 41(1): 88-94, Jan 1991.
Uematsu D, Greenberg J H, Hickey W F, Reivich M: Nimodipine attenuates both increase in cytosolic free calcium and histologic damage following focal cerebral ischemia and reperfusion in cats. Stroke 20(11): 1531-7, Nov 1989.
Greenberg J H, Reivich M, Alavi A, Hand P, Rosenquist A, Rintelmann W, Stein A, Tusa R, Dann R, Christman D, Fowler J, MacGregor B, Wolf A: Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique. Science 212(4495): 678-80, May 1981.