faculty photo

Jay A. Gottfried, M.D., Ph.D.

Clinical Associate of Neurology
Department: Neurology

Contact information
Stellar-Chance Laboratories, 5th Floor
422 Curie Blvd
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
BA (Molecular Biology)
Princeton University, 1989.
Ph.D. (Physiology/Neuroscience)
New York University, 1997.
MD (Medicine)
New York University, 1997.
Post-Graduate Training
Intern in General Medicine, Mount Sinai Medical Center, New York, NY, 1997-1998.
Resident in Adult Neurology, University of Pennsylvania, Philadelphia, PA, 1998-2001.
HHMI Physician-Scientist Postdoctoral Fellow, Olfactory Neuroscience and Neuroimaging, University College London, London, UK, 2001-2004.
Certifications
American Board of Psychiatry and Neurology, 2003.
American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Research Interests:
Our lab focuses on understanding how the human brain transforms olfactory inputs into perceptual representations, and how learning, memory, and experience modulate this information to enhance odor object recognition and discrimination at the behavioral, cognitive, and neural levels.

Keywords:
Sensory Systems and Perception; Olfaction; Behavioral Neuroscience; Cognitive Neuroscience; Functional MRI; Intracranial EEG; Psychophysics; Neuroanatomy and Immunostaining

Research Details:
Our research can be thematically organized into three broad components ranging from the microscopic to the macroscopic: molecular and cellular analysis of human olfactory tissue; in vivo electrophysiological analysis using intracranial EEG recordings in patients with temporal lobe epilepsy; and systems-level analysis using functional MRI and olfactory psychophysical techniques in human subjects, and also in mouse subjects. Currently even the most well-founded research assumptions – the cellular organization of the peripheral olfactory system; the cortical projection pathways and centrifugal feedback connections; the physiological coding principles that underlie odor processing and memory consolidation – remain almost completely untested in humans. Together these different research strands support a consolidated research platform to investigate human olfaction with a neuroscientific breadth intended to connect the dots from molecules to mind, and from health to disease.

Description of Clinical Expertise

Neurobehavioral Disorders
Cognitive Neurology
Disorders of Smell and Taste
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Last updated: 09/28/2017
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