Brian Litt, MD
Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology
Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Fax: (215)-349-5733
Email:
littb@pennmedicine.upenn.edu
littb@pennmedicine.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Lab Web Page
Penn Neuroengineering Research Lab
Center for Neuroengineering and Therapeutics
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
PennBrain
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Search PubMed for articles
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Lab Web Page
Penn Neuroengineering Research Lab
Center for Neuroengineering and Therapeutics
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
PennBrain
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Education
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Certifications
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Permanent linkAmerican Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Description of Research Expertise
Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.Description of Clinical Expertise
Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEGDescription of Other Expertise
Entrepreneurship:I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000
I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.
I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).
I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)
I have participated in helping bring several implantable NeuroDevices to market.
Selected Publications
Pattnaik AR, Xu Z, Ojemann WKS, Aguila CA, Lucas A, Lavelle S, Goldblum Z, Galer PD, Gallagher R, Davis KA, Sinha N, Conrad EC, Litt B.: The seizure embedding map: a spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale. J Neural Eng 23: 046011, Jul 2026.Dong R, Chen Y, Garg R, Averbeck SR, Wun C, Unegbu P, Shankar S, Ahmad S, Jung J, Zahed MA, Zhang D, Gogotsi Y, Takano H, Litt B, Vitale F.: Artifact-free, colocalized opto-electrophysiology enabled by a flexible, multimodal interface integrating transparent MXene microelectrodes and microLEDs. Biosens Bioelectron 304: 118620, Jul 2026.
Feys O, Walsh KG, Nix KC, Josyula M, Sinha N, Lavelle SB, Wagenaar J, Michalak A, Morrell MJ, Jeschke J, Khambhati AN, Conrad EC, Kleen JK, Litt B, Rao VR, Friedman D, Davis KA.: Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement. medRxiv Jun 2026.
Conrad EC, Chang E, Xie K, Aguila CA, Kim J, Shi H, Ojemann WK, Jing J, Westover MB, Sinha SR, Litt B, Davis KA, Cao Q, Ellis CA.: Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort. medRxiv Jun 2026.
Davis P, B Tomlinson S, Armstrong C, Conrad EC, Ojemann WKS, Peters J, Litt B, Gilman C, Kennedy BC, Marsh ED.: Cortical stimulation reveals effective disconnection of the epileptogenic network at seizure onset. Epilepsia Jun 2026.
Aguila CA, Zhou Z, Lavelle SB, Ojemann WKS, Kim J, Walsh K, Mournani SS, Lucas A, Sinha N, Feys O, Scheid BH, Davis KA, Litt B, Conrad EC.: Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases. medRxiv May 2026.
Vizcarra JA, Hefter K, Lafontant DE, Duong MT, Ertefaie A, Litt B, Bassett DS, Siderowf A; Parkinson's Progression Markers Initiative.: Sex Differences in Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis. Mov Disord Clin Pract May 2026.
Kojima J, Shi H, Jaikumar S, Ojemann WKS, Aguila C, Kim J, Ganguly TM, Litt B, Conrad EC.: How Much Does the Reduced EEG Montage Matter for Seizure Detection?: A Large-Cohort Simulation Study. medRxiv May 2026.
Chen Y, Litt B, Vitale F, Takano H.: On-demand seizures facilitate rapid screening of therapeutics for epilepsy. Elife 13: RP101859, Apr 2026.
Haggerty J, Qureshi Q, Gabriel ED, Borges PG, Davis P, Wingel K, Cai J, Sargur K, Kim MJ, Dubey A, Garwood I, Vaz A, Richardson AG, Chen HI, Hammer LH, Gold J, Litt B, Yoshor D, Beauchamp M, Halpern C, Pesaran B, Cajigas I.: Thalamus: a real-time system for synchronized, closed-loop multimodal behavioral and electrophysiological data capture. Commun Eng 5: 93, Mar 2026.