faculty photo

Brian Litt, MD

Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Certifications
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise

Entrepreneurship:

I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000


I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

John M Bernabei, Adam Li, Andrew Y Revell, Rachel J Smith, Kristin M Gunnarsdottir, Ian Z Ong, Kathryn A Davis, Nishant Sinha, Sridevi Sarma, Brian Litt: Quantitative approaches to guide epilepsy surgery from intracranial EEG. BRAIN advanced online, January 2023.

TC Arnold, CW Freeman, B Litt, JM Stein: Low‐field MRI: Clinical promise and challenges. Journal of Magnetic Resonance Imaging 57(1): 25-44, January 2023.

Erin C Conrad, Andrew Y Revell, Adam S Greenblatt, Ryan S Gallagher, Akash R Pattnaik, Nicole Hartmann, James J Gugger, Russell T Shinohara, Brian Litt, Eric D Marsh, Kathryn A Davis: Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy. Epilepsia online ahead of print, December 2022.

Brian Litt: Engineers drive new directions in translational epilepsy research. BRAIN 145(11): 3725-3726, November 2022.

TC Arnold, D Tu, S Okar, G Nair, S By, K Kawatra, T Roberts-Fitzgerald, L Desiderio, M Schindler, B Litt, R Shinohara, D Reich, J Stein: Assessing lesion sensitivity and brain atrophy using portable low-field MRI in multiple sclerosis. The Multiple Sclerosis Journal 10: 975-976, October 2022.

Rory J Piper, R Mark Richardson, Gregory Worrell, David W Carmichael, Torsten Baldeweg, Brian Litt, Timothy Denison, Martin M Tisdall: Towards network-guided neuromodulation for epilepsy. BRAIN 145(10): 3347-3362, October 2022.

Barbara M Decker, Alexandra Turco, Jian Xu, Samuel W Terman, Nikitha Kosaraju, Alisha Jamil, Kathryn A Davis, Brian Litt, Colin A Ellis, Pouya Khankhanian, Chloe E Hill: Development of a natural language processing algorithm to extract seizure types and frequencies from the electronic health record. Seizure 101: 48-51, October 2022.

Erin C Conrad, John M Bernabei, Nishant Sinha, Nina J Ghosn, Joel M Stein, Russell T Shinohara, Brian Litt: Addressing spatial bias in intracranial EEG functional connectivity analyses for epilepsy surgical planning. Journal Of Neural Engineering 19(5): 056019, September 2022.

Arian Ashourvan, Sérgio Pequito, Maxwell Bertolero, Jason Z Kim, Danielle S Bassett, Brian Litt: External drivers of BOLD signal’s non-stationarity. Plos One 17(9): e0257580, September 2022.

Erin C Conrad, Russell T Shinohara, James J Gugger, Andrew Y Revell, Sandhitsu Das, Joel M Stein, Eric D Marsh, Kathryn A Davis, Brian Litt: Implanting intracranial electrodes does not affect spikes or network connectivity in nearby or connected brain regions. Network Neuroscience 6(3): 834-849, July 2022.

back to top
Last updated: 01/30/2023
The Trustees of the University of Pennsylvania