faculty photo

Brian Litt, MD

Professor of Neurology and Professor of Bioengineering
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise


I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000

I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Litt Brian: Engineering the next generation of brain scientists. Neuron 86(1): 16-20, Apr 2015.

Ives Z, Yan Z, Zheng N, Litt B, Wagenaar J: Looking at Everything in Context. Conference paper, 7th biennial Conference on Innovative Data Systems Research (CDIR) 2015.

Wulsin D, Fox E, Litt B: Modeling the complex dynamics and changing correlations of epileptic events. Artificial Intelligence 216: 55-75, Nov. 2014.

Duygu Kuzum, Hajime Takano, Euijae Shim, Jason C. Reed, Halvor Juul, Andrew G. Richardson, Julius de Vries, Hank Bink, Mark Dichter, Timothy H. Lucas, Douglas A. Coulter, Ertugrul Cubukcu, Brian Litt: Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nature Communications 5: 5259, October 2014.

Geller Aaron S, Burke John F, Sperling Michael R, Sharan Ashwini D, Litt Brian, Baltuch Gordon H, Lucas Timothy H, Kahana Michael J: Eye closure causes widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 125(9): 1764-73, Sep 2014.

Weixuan Chen, Xilin Liu, Litt B: Logistic-weighted regression improves decoding of finger flexion from electrocorticographic signals. Conf Proc IEEE Eng Med Biol Soc. Page: 2629-32, August 2014.

Denison Timothy, Litt Brian: Advancing neuromodulation through control systems: a general framework and case study in posture-responsive stimulation. Neuromodulation : journal of the International Neuromodulation Society 17 Suppl 1: 48-57, Jun 2014.

Escabi Monty Armando, Read Heather L, Viventi Jonathan, Kim Dae-Hyeong, Higgins Nathan C, Storace Douglas, Liu Andrew S K, Gifford Adam M, Burke John F, Campisi Matthew, Kim Yun-Soung, Avrin Andrew E, Van der Spiegel Jan, Huang Yonggang, Li Ming, Wu Jian, Rogers John A, Litt Brian, Cohen Yale E: A high-density, high-channel count, multiplexed µECoG array for auditory-cortex recordings. Journal of neurophysiology Jun 2014.

Rodriguez Merzagora Anna, Coffey Thomas J, Sperling Michael R, Sharan Ashwini, Litt Brian, Baltuch Gordon, Jacobs Joshua: Repeated stimuli elicit diminished high-gamma electrocorticographic responses. NeuroImage 85 Pt 2: 844-52, Jan 2014.

Howbert J Jeffry, Patterson Edward E, Stead S Matt, Brinkmann Ben, Vasoli Vincent, Crepeau Daniel, Vite Charles H, Sturges Beverly, Ruedebusch Vanessa, Mavoori Jaideep, Leyde Kent, Sheffield W Douglas, Litt Brian, Worrell Gregory A: Forecasting seizures in dogs with naturally occurring epilepsy. PloS one 9(1): e81920, 2014.

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Last updated: 01/08/2021
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