Department of Neurology

Department of Neurology
faculty photo

Sabrina W. Yum, M.D.

Assistant Professor of Neurology at the Children's Hospital of Philadelphia
Attending Neurologist, Children's Hospital of Philadelphia
Department: Neurology

Contact information
Abramson Research Building, Rm502A
3615 Civic Center Boulevard
Philadelphia, pa 19104
Office: 215-590-1719
Fax: 215-590-1771
Education:
M.D. (Medicine)
Guangzhou Medical College, 1983.
Post-Graduate Training
Postdoctoral Research Fellow, Center for Neural Injury, University of California, San Francisco/Veterans Administration Medical Center, 1985-1989.
Intern in Pediatrics , Albert Einstein College of Medicine/Montefiore Medical Center, NY, 1989-1990.
Resident in Pediatrics, Albert Einstein College of Medicine/Montefiore Medical Center, NY, 1990-1992.
Fellow in Pediatric Neurology, Dept. of Neurology at Johns Hopkins University School of Medicine , 1992-1995.
Fellow in Neuromuscular Diseases and EMG, Dept. of Neurology at University of Pennsylvania, 1995-1996.
Certifications
USA Educational Commission for Foreign Medical Graduate Certificate ( No. 405-021-7) , 1987.
American Board of Pediatrics (No. 052501), 1993.
American Board of Psychiatry and Neurology, with special qualification in child neurology (No. 1065), 1997.
American Board of Psychiatry and Neurology, in the subspecialty of clinical Neurophysiology (No. 1211), 1999.
American Board of Psychiatry and Neurology, with special qualification in Child Neurology (No. 1065), re-certification, 2007.
American Board of Psychiatry and Neurology, in the subspecialty of clinical Neurophysiology (No. 1211), re-certification , 2009.
American Board of Psychiatry and Neurology, in the subspecialty of Neuromuscular Medicine (No. 626) , 2012.
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Description of Research Expertise

Biology and pathogenesis of connexin mutations associated with Charcot-Marie-Tooth disease, hearing loss
The role of neurofilaments in axonal degeneration
Charcot-Marie-Tooth disease

Description of Clinical Expertise

Pediatric Neurology
Pediatric Neuromuscular diseases
Charcot-Marie-Tooth disease
Nerve conduction study and EMG
Muscle ultrasound
BOTOX injection for patients with movement disorders

Selected Publications

27. Sanmaneechai O, Feely S, Scherer SS, Herrmann DN, Burns J, Muntoni F, Li J, Siskind CS, Day JW, Laura M, Sumner CJ, Lloyd TE, Ramchandren S, Shy RR, Grider T, Bacon C, Finkel RS, Yum SW, Moroni I, Piscosquito G, Pareyson D, Reilly MM, Michael E. Shy ME and the Inherited Neuropathies Consortium - Rare Disease Clinical Research Consortium (INCRDCRC): Phenotype-genotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the Myelin Protein Zero gene. Brain Epub 2015 Aug 25, August 2015.

Harding BN, Kariya S, Monani UR, Chung W, Benton M, Yum SW, and Finkel RS: Spectrum of Neuropathophysiology in Spinal Muscular Atrophy type I. JNEN 74(1): 15-24, 2015.

Kayla MD. Cornett KMD, Menezes MP, Shy R, Yum SW, Estilow T, Moroni I, Pagliano E, Pareyson D, Laura M, Muntoni F, Reilly MM, Finkel RS, Eichinger K, Herrmann DN, Shy ME, Burns J, on behalf of the Inherited Neuropathies Consortium: Rate of Charcot-Marie-Tooth disease progression during childhood. Journal of Peripheral Nervous System Journal of Peripheral Nervous System 2015.

Yum, SW: What are the most important components of the exam in evaluating a hypotonic Baby? Curbside Consultation in Pediatric Neurology: 49 Clinical Questions Licht DJ, Ryan NR (eds.). SLACK Incorporated, 2015.

Jenssen BP, Lautz AJ, Yum SW, Waanders A, Fox E (2015): A 6 year old girl with leg cramp. Pediatrics Accepted for publication, 2015.

Kayla MD. Cornett KMD, Menezes MP, Shy R, Yum SW, Estilow T, Moroni I, Pagliano E, Pareyson D, Laura M, Muntoni F, Reilly MM, Finkel RS, Eichinger K, Herrmann DN, Shy ME, Burns J, on behalf of the Inherited Neuropathies Consortium: Heterogeneity of Charcot-Marie-Tooth disease severity during childhood. Journal of Peripheral Nervous System 2015.

Kamiya k, Yum SW, Kurebayashi-Kunihiro N, Muraki M, Ogawa K, Karasawa K, Gotoh R, Suginani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K: Connexin26 mutations that cause hereditary deafness lead to macromolecular complex degradation of cochlear gap junction plaques. J Clinical Investigation 124(4): 1598-607, April 2014.

Guo X and Yum SW : Role of mitochondrial reactive oxygen species in cell death caused by connexin 26 mutations associated with keratitis-ichthyosis-deafness syndrome. Neurology 82(10): Supplement P2.281 April 2014.

Brownstein C, Beggs A, Homer N, Merriman B, et al, Yum SW, et al, Kohane I, Margulies D: An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results: The CLARITY Challenge. Genome Biology 15(3): R53, March 2014.

Fridman V, Bacon C, Burns J, Day J, Feely S, Finkel RS, Grider T, Hall C, Hermann DN, LaurĂ¡ M, Li J, Lloyd T., Muntoni F, Pareyson D, Ramchandren S, Reilly MM, Scherer S, Shy R, Sorey A, Yum SW, Zuhner S, Shy ME: Distribution of CMT Subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium (INC) Natural History Study between 2009 and 2014. JNNP Page: 1-6, 2014.

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Last updated: 09/04/2015
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