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Alice S. Chen-Plotkin, MD

Parker Family Associate Professor of Neurology
Attending Neurologist, Pennsylvania Hospital
Attending Neurologist, Hospital of the University of Pennsylvania
Department: Neurology

Contact information
Hospital of the University of Pennsylvania
150 Johnson Pavilion
Philadelphia, PA 19104
Office: 215-829-6500
Lab: 215-746-8191
Graduate Group Affiliations
AB (English)
Harvard-Radcliffe College, 1996.
MSc (Biology)
University of Oxford, 1998.
Harvard Medical School, 2003.
Post-Graduate Training
Intern in Medicine, Brigham and Women's Hospital, Harvard Medical School, 2003-2004.
Resident in Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Partners Neurology, Harvard Medical School, 2004-2007.
Fellow in Movement Disorders, Pennsylvania Hospital, University of Pennsylvania School of Medicine, 2007-2008.
Postdoctoral Research in Neurodegenerative Disease, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 2007-2010.
American Board of Psychiatry and Neurology (Neurology), 2008.
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Description of Research Expertise

The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes. Our general approach is to use unbiased genomic- or proteomic-scale screens to generate leads, which are then followed mechanistically in relevant systems. The rationale behind using genomic/proteomic-scale screens of genetic variation, mRNA expression, microRNA expression, or protein expression is that (1) they avoid bias generated by one’s preconceptions of what may be key disease genes or proteins and (2) they can give one a more global picture of pathophysiology, a picture that encompasses what is happening to an organism as a whole, or at least an organism’s genome/proteome as a whole, as these diseases progress. To conduct the type of research outlined here, we employ a combination of bench and computational methods.

Description of Clinical Expertise

Movement disorders
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Last updated: 06/21/2019
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