Alice S. Chen-Plotkin, MD
150 Johnson Pavilion
Philadelphia, PA 19104
Harvard-Radcliffe College, 1996.
University of Oxford, 1998.
Harvard Medical School, 2003.
Intern in Medicine, Brigham and Women's Hospital, Harvard Medical School, 2003-2004.
Resident in Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Partners Neurology, Harvard Medical School, 2004-2007.
Postdoctoral Research in Neurodegenerative Disease, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 2007-2010.
Fellow in Movement Disorders, Pennsylvania Hospital, University of Pennsylvania School of Medicine, 2007-2008.
American Board of Psychiatry and Neurology (Neurology), 2008.
Description of Research ExpertiseThe over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes.
Our general approach is to use unbiased genomic- or proteomic-scale screens in human-derived materials to generate leads, which are then followed mechanistically in relevant systems including neuronal culture and in vivo animal models. The pace of technology development is allowing us to acquire more data, faster, than ever before, but this does not always translate into biological understanding. We believe that to unlock the true potential of leads generated in this way, computational methods must work hand-in-hand with bench-based manipulative experiments.