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Jennifer McGuire, M.D., M.S.C.E.

Assistant Professor of Neurology at the Children's Hospital of Philadelphia
Associate Program Director, Child Neurology Residency, Children's Hospital of Philadelphia
Pediatric Neurology block director within MS1 Brain and Behavior course, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Hub for Clinical Collaboration
10th Floor, Division of Neurology
3501 Civic Center Blvd
Philadelphia, PA 19104
Education:
B.S. (Chemical Engineering, cum laude)
Cornell University, 2000.
M.D.
Dartmouth Medical School, 2005.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2014.
Post-Graduate Training
Intern in Pediatrics, University of Colorado Health Sciences Center, 2005-2006.
Resident in Pediatrics, University of Colorado Health Sciences Center, 2006-2007.
Fellow in Child Neurology, Children’s Hospital of Philadelphia; University of Pennsylvania, 2007-2010.
Research Fellow in Clinical Epidemiology, with a focus on Pediatric Neuroimmunology and Neurological Infections, Children’s Hospital of Philadelphia; University of Pennsylvania, 2010-2012.
Certifications
American Board of Psychiatry and Neurology, with Special Qualification in Child Neurology, 2010.
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Description of Research Expertise

HIV-associated neurocognitive disorders in adolescents
Host immune system modulation of viral infections in the central nervous system.
Viral encephalitis

Description of Clinical Expertise

General Child Neurology
Infectious Diseases of the Nervous System
Neurologic complications of HIV

Selected Publications

McGuire JL, Douglas SD: Neuroimmune Dysregulation in HIV-Associated Neurocognitive Disorders. Psychiatric Annals 43(5): 212-216, 2013.

McGuire JL, Goodkin K, Douglas SD: The Neuropathogenesis of Central Nervous System HIV Infection. Psychiatric Annals 43(5): 217-222, 2013.

JL McGuire and AM Greene: Central Nervous System Infections (Chapter 16). Pediatric Neurocritical Care. NS Abend and M Helfaer (eds.). Demos, New York, Page: 267-336, 2013.

JL McGuire, JH Kempen, JE Ellenberg, SD Douglas: Immune Markers of Neuropsychiatric Outcomes in HIV Infected Adolescents. International Society of Neurovirology Annual Meeting, New York, NY April 2012 Notes: poster.

JL McGuire, J Zorc, D Licht RL Hodinka, SS Shah: Herpes Simplex Testing in Neonates and Young Infants in the Emergency Department. Pediatric Emergency Care 28(10): 949-955, 2012.

JL McGuire, V Fridman, I Koralnik, D Jacobs: Progressive Multifocal Leukoencephalopathy in a Patient with an Isolated CD8+ T Cell Deficiency. J Neurovirol 17: 500-503, 2011.

JL McGuire: What are the Clinical Features of Infant Bolulism? How is it Treated? (chapter 26). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 123-126, 2015.

JL McGuire: Mycoplasma Encephalitis (chapter 8). Symptom-Based Diagnosis in Pediatrics. SS Shah, S Ludwig (eds.). McGraw-Hill Professional, New York, Page: 208-211, 2013.

JS Barrett, G Bajaj, JL McGuire, D Wu, S Spitsin, G Moorthy, X Zhao, P Tebas, DL Evans, SD Douglas: Modeling and Simulation Support for Dosing and Study Design Requirements for Treating HIV-Related Neuropsychiatric Disease with the NK1r Antagonist Aprepitant. Current HIV Research 12(2): 121-131, 2014.

JL McGuire, LA Beslow, RS Finkel, RA Zimmerman, FA Henretig: A Teenager with Focal Weakness. Pediatric Emergency Care 24(12): 875-879, 2008.

AA Link, T Kino, JA Worth, JL McGuire, ML Crane, GP Chrousos, RL Wilder, and IJ Elenkov: Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes J. Immunology 164: 436-442, 2000.

JL McGuire: What are the Causes of Guillain-Barre Syndrome, How Often Does it Occur, and How is it Treated? (chapter 32). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 157-162, 2015.

JS Barrett, JL McGuire, H Vezina, S Spitsin, SD Douglas: PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: Are we asking the right questions? Journal of Clinical Psychopharmacology 33(6): 725-728, 2013.

JL McGuire, JS Barrett, H Vezina, S Spitsin, SD Douglas: Adjuvant Therapies for HIV-Associated Neurocognitive Disorders. Annals of Clinical and Translational Neurology 1(11): 938-952, 2014.

JL McGuire, J Kempen, R Localio, JE Ellenberg, SD Douglas: Immune Markers Predictive of Neuropsychiatric Symptoms in HIV Infected Youth. Clinical and Vaccine Immunology 22(1): 27-36, 2015.

AJ Lautz, B Jenssen, JL McGuire, JA St Geme: Diagnostic Dilemmas and Clinical Reasoning: A 33-month old with fever and altered mental status. Pediatrics 135(1): 120-125, 2015 Notes: Epub ahead of print 12/8/14.

JL McGuire, A Gill, SD Douglas, D Kolson: Central and Peripheral Markers of Neurodegeneration and Monocyte Activation in HIV-Associated Neurocognitive Disorders. J Neurovirology 21(4): 439-48, Aug 2015.

NS Abend, D Bearden, I Helbig, J McGuire, S Narula, JA Panzer, A Topjian, DJ Dlugos: Status Epilepticus and Refractory Status Epilepticus Management. Seminars in Pediatric Neurology 21: 263-274, 2014.

JL McGuire, A Gill, SD Douglas, D Kolson: The Complement System, Neuronal Injury, and Cognitive Function in Horizontally-Acquired HIV-Infected Youth. J Neurovirology 22(6): 823-830, June 2016 Notes: DOI: 10.1007/s13365-016-0460-5.

Gofshteyn, J; Shaw, P.A.; Teachey D.T.; Grupp, S; Maude, S; Banwell, B; Chen F; Lacey, S.F.; Melenhorst, J.J.; Edmonson M.J.; Panzer J; Barrett D.M. and McGuire, J: Neurotoxicity after CTL-19 in a Pediatric and Young Adult Cohort. Annals of Neurology 84(4): 537-546, Oct 2018 Notes: doi: 10.1002/ana.25315.

McGuire JL, Tuite N, Swami S, Avery RA: Assessment of the Diagnostic Yield of Non-Culture CSF Infection Testing in Children. JAMA Network Open 2(7): e197307, July 2019.

Matesanz S*, McGuire JL*, Hopkins S, *co-first authors: Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center. J Pediatr 215: 272-276.e1, December 2019 Notes: doi: 10.1016/j.jpeds.2019.07.015 [Epub ahead of print]

WR Otto, WZ Paden, M Connors, T Joerger, A Buzi, M Rizzi, J Huh, PB Storm, G Heuer, B Kennedy, J McGuire, S Swami, SS Lang: Suppurative intracranial complications of pediatric sinusitis: a single-center experience. J Pediatric Infect Dis Soc 10(3): 309-316, Apr 2021 Notes: doi: 10.1093/jpids/piaa101.

AE Becker, K Chiotos, JL McGuire, BB Bruins, AM Alcamo: Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children. J Pediatr 233: 263-267, June 2021.

C Del Valle Mojica, J Montoya, J McGuire, KL Plama, KV Shekdar, R McLeod, DG Contopoulos-Ioannidis: Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report. J Pediatr S0022-3476(21): Epub ahead of print. May 2021 Notes: doi: 10.1016/j.jpeds.2021.05.040.

V Dhawan, JL McGuire, K Busl: Emergency Neurologic Life Support: Meningitis and Encephalitis Module V 5.0. Neurocritical Care Society Publishing. G Lopez, S Peacock, and A Aysenne (eds.). March 2022.

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Last updated: 11/01/2023
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