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Jennifer McGuire, M.D., M.S.C.E.

Assistant Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building
10th Floor, Division of Neurology, Room 10032
3501 Civic Center Blvd
Philadelphia, PA 19104
B.S. (Chemical Engineering, cum laude)
Cornell University, 2000.
Dartmouth Medical School, 2005.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2014.
Post-Graduate Training
Intern in Pediatrics, University of Colorado Health Sciences Center, 2005-2006.
Resident in Pediatrics, University of Colorado Health Sciences Center, 2006-2007.
Fellow in Child Neurology, Children’s Hospital of Philadelphia; University of Pennsylvania, 2007-2010.
Research Fellow in Clinical Epidemiology, with a focus on Pediatric Neuroimmunology and Neurological Infections, Children’s Hospital of Philadelphia; University of Pennsylvania, 2010-2012.
American Board of Psychiatry and Neurology, with Special Qualification in Child Neurology, 2010.
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Description of Research Expertise

HIV-associated neurocognitive disorders in adolescents
Host immune system modulation of viral infections in the central nervous system.
Viral encephalitis

Description of Clinical Expertise

General Child Neurology
Infectious Diseases of the Nervous System
Neurologic complications of HIV

Selected Publications

McGuire JL, Douglas SD: Neuroimmune Dysregulation in HIV-Associated Neurocognitive Disorders. Psychiatric Annals 43(5): 212-216, 2013.

McGuire JL, Goodkin K, Douglas SD: The Neuropathogenesis of Central Nervous System HIV Infection. Psychiatric Annals 43(5): 217-222, 2013.

JL McGuire and AM Greene: Central Nervous System Infections (Chapter 16). Pediatric Neurocritical Care. NS Abend and M Helfaer (eds.). Demos, New York, Page: 267-336, 2013.

JL McGuire, JH Kempen, JE Ellenberg, SD Douglas: Immune Markers of Neuropsychiatric Outcomes in HIV Infected Adolescents. International Society of Neurovirology Annual Meeting, New York, NY April 2012 Notes: poster.

JL McGuire, J Zorc, D Licht RL Hodinka, SS Shah: Herpes Simplex Testing in Neonates and Young Infants in the Emergency Department. Pediatric Emergency Care 28(10): 949-955, 2012.

JL McGuire, V Fridman, I Koralnik, D Jacobs: Progressive Multifocal Leukoencephalopathy in a Patient with an Isolated CD8+ T Cell Deficiency. J Neurovirol 17: 500-503, 2011.

JL McGuire: What are the Clinical Features of Infant Bolulism? How is it Treated? (chapter 26). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 123-126, 2015.

JL McGuire: Mycoplasma Encephalitis (chapter 8). Symptom-Based Diagnosis in Pediatrics. SS Shah, S Ludwig (eds.). McGraw-Hill Professional, New York, Page: 208-211, 2013.

JS Barrett, G Bajaj, JL McGuire, D Wu, S Spitsin, G Moorthy, X Zhao, P Tebas, DL Evans, SD Douglas: Modeling and Simulation Support for Dosing and Study Design Requirements for Treating HIV-Related Neuropsychiatric Disease with the NK1r Antagonist Aprepitant. Current HIV Research 12(2): 121-131, 2014.

JS Barrett, JL McGuire, H Vezina, S Spitsin, SD Douglas: PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: Are we asking the right questions? Journal of Clinical Psychopharmacology 33(6): 725-728, 2013.

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Last updated: 03/04/2020
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