Ethan M. Goldberg | Department of Neurology | Perelman School of Medicine at the University of Pennsylvania

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Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology

Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia

Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania

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Department: Neurology

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46 Contact information
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The Children's Hospital of Philadelphia
1d Division of Neurology
2b Abramson Research Center, Room 510D
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104

2e Office: 215-590-6894
32 Fax: 215-590-1771
32 Lab: 215-590-5671
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Email:
goldberge@email.chop.edu

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1f Graduate Group Affiliations 8

Neuroscience

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18 Publications
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26 Search PubMed for articles c

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Links
e1 Search PubMed for articles
7b The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
94 Division of Neurology, The Children's Hospital of Philadelphia
5b Goldberg Lab Web Link
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13 Education:
21 9 B.A. 19 (Neurobiology) c
2b Harvard University, 1999.
21 a Ph.D. 26 (Physiology & Neuroscience) c
3f New York University School of Medicine, 2006.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 2008.
21 a Cert. 6d (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER)) c
39 University of Wisconsin-Madison , 2022.
21 a Cert. 31 (Raising a Resilient Scientist Series) c
6d National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
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1f Post-Graduate Training
24 5b Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
24 5d Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
24 95 Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
24 70 Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
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17 Certifications
28 4a American Board of Psychiatry and Neurology (ABPN), 2013.
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3 8d Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Clinical Expertise

8e Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.
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Description of Research Expertise

60 Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.
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Selected Publications

163 Prentice, A.J., McSalley, I., Magielski, J.H., Mercurio, J., Tefft, S., Winters, A., Kaufman, M.C., Ruggiero, S.M., McGarry, L., Hood, V., McKee, J.L., Goldberg, E., Helbig, I.: Characterizing SCN1A-Related Disorders Using Real-World Data Across 681 Patient-Years. medRxiv Mar 2026.

ef Hill, S.F., Goldberg, E.M.: A hit for base editing: Treatment of developmental epilepsy in a mouse model. Journal of Clinical Investigation 136(3): e200689, Feb 2026.

182 Hill, S.F., Enakhimion, E.A., Furlanis, E., Dai, M., Garcia, B.L., Willis, S., Tran, T., Fishell, G., Wang, Y., Goldberg, E.M.: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome. bioRxiv 2026.02.02.702918, 2026 Notes: doi: https://doi.org/10.64898/2026.02.02.702918.

125 Dabrowski, A., Somarowthu, A., Liebergall, S., Lorenzo, D., Goldberg, E.M.: Compensatory rearrangement of parvalbumin interneuron voltage-gated sodium channel subunits in a mouse model of Dravet syndrome. Epilepsia 2026.

232 Ellis, C.A., Copeland, J., Velez, I., Oliver, K.L., Shalaby, H., Baldwin, A., Armstrong, C., Back, A., Berlin, B., Cohen, S., Cuddapah, V.A., deCampo, D., Dubbs, H., Ginn, N., Harrison, A.G., Lewin, N., Lusk, L., Marsh, E.D., Massey, S.L., McDonnell, P.P., McKee, J.L., Ortiz-Gonzalez, X., Prentice, A.J., Sullivan, K.R., Taub, K.S., Ruggiero, S.M., Fitzgerald, M.P., Goldberg, E., Helbig, I.: Genetic testing for familial epilepsies: diagnostic yield and genetic findings. Epilepsia 2026.

f9 Clatot, J., Monnerie, H., Panzer, A., Platzer, K., Goldberg, E.M.: An epilepsy-associated KV3.1 potassium channel variant acts via dominant positive effect. J Gen Physiol 2026.

127 Sherer, M., Goldberg, E.M.: Flip of the Switch: Targeting GABA Dysregulation to Treat Nonseizure Comorbidities in Dravet Syndrome. Epilepsy Currents Nov 14 2025 Notes: Online ahead of print. doi: 10.1177/15357597251389967.

134 Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.

181 Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. 50 bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 1e Jun 2025.

1c9 Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.

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26 Last updated: 05/27/2026
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