Ethan M. Goldberg, M.D., Ph.D.
Associate Professor of Neurology
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
Department: Neurology
Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Fax: 215-590-1771
Lab: 215-590-5671
Email:
goldberge@email.chop.edu
goldberge@email.chop.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
Division of Neurology, The Children's Hospital of Philadelphia
Goldberg Lab Web Link
Search PubMed for articles
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
Division of Neurology, The Children's Hospital of Philadelphia
Goldberg Lab Web Link
Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
Certifications
American Board of Psychiatry and Neurology (ABPN), 2013.
Permanent linkAmerican Board of Psychiatry and Neurology (ABPN), 2013.
Description of Clinical Expertise
Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.Description of Research Expertise
Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.Selected Publications
Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. bioRxiv July 2024 Notes: doi.org/10.1101/2024.07.17.603924.Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability Epilepsy Currents 24(4), Jul-Aug 2024.
Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, Apr 2024.
Liebergall S.R., Goldberg, E.M. : Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome. J Neurosci 44(17): e1977232024, Apr 2024.
Clatot, J., Goldberg, E.M.: No Pain, No Gain of Function: Epilepsy-Associated Variants in SCN2A Defy Classification Epilepsy Currents 24(2): 126-128, Mar-Apr 2024.
Gracia-Diaz, C., Perdomo, J.E., Kham, M.E., Disanza, B., Cajka, G.G., Lei, S., Gagne, A., Maguire, J.A., Roule, T., Shalem, O., Bhoj, E.J., Ahrens-Nicklas, R.C., French, D., Goldberg, E.M., Wang, K., Glessner, J., Akizu, N.: High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs Cell Stem Cell 31(3): 288-289, Mar 2024.
Feng, H., Clatot, J., Kaneko, K., Flores-Mendez, M., Wengert, E.R., Koutcher, C., Hoddeson, E., Lopez, E., Lee, D., Arias, L., Liang, Q., Zhang, X., Somarowthu, A., Covarrubias, M., Gunthorpe, M.J., Large, C.H.., Akizu, N., Goldberg, E.M.: Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Reports Medicine 4(2): 101389, Feb 2024.
Clatot, J., Currin, C.B., Liang, Q., Pipatpolkai, T., Massey, S.L., Helbig, I., Delemotte, L., Vogels, T.P., Covarrubias, M., Goldberg, E.M.: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. PNAS 121(3): e2307776121, Jan 2024.
Waxman, E., Dungan, L., DeFlitch, L., Merchant, J., Gagne, A., Goldberg, E.M., French, D.: A Reproducible Protocol for Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Excitatory Cortical Neuron Cultures with Checkpoints for Success. Current Protocols 3(12): e948, Dec 2023.
Fadila, S., Beucher, B., González-Dopeso Reyes, I., Mavashov, A., Brusel, M., Anderson, K., Goldberg, E.M., Ricobaraza, A., Hernandez-Alcoceba, R., Kremer, E.J., Rubinstein, M.: Exogenous NaV1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet. J Clin Invest 133(12), June 2023.