Ethan M. Goldberg, M.D., Ph.D.
Associate Professor of Neurology
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
Department: Neurology
Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Fax: 215-590-1771
Lab: 215-590-5671
Email:
goldberge@email.chop.edu
goldberge@email.chop.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
Division of Neurology, The Children's Hospital of Philadelphia
Goldberg Lab Web Link
Search PubMed for articles
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
Division of Neurology, The Children's Hospital of Philadelphia
Goldberg Lab Web Link
Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
Certifications
American Board of Psychiatry and Neurology (ABPN), 2013.
Permanent linkAmerican Board of Psychiatry and Neurology (ABPN), 2013.
Description of Clinical Expertise
Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.Description of Research Expertise
Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.Selected Publications
Goff, K.M., Liebergall, S.R., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Reports 42(6), Jun 2023.Fadila, S., Beucher, B., González-Dopeso Reyes, I., Mavashov, A., Brusel, M., Anderson, K., Goldberg, E.M., Ricobaraza, A., Hernandez-Alcoceba, R., Kremer, E.J., Rubinstein, M.: Exogenous NaV1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet. J Clin Invest 133(12), June 2023.
Clatot, J., Ginn, N., Costain, G., Goldberg, E.M.: A KCNC1-related neurological disorder due to gain of Kv3.1 function. Ann Clin Trans Neurol Jan 2023.
Kravchenko, J.A., Goldberg, E.M., Mattis, J.: Optogenetic and chemogenetic manipulation of seizure threshold in mice. STAR Protoc 4(1): 102019, Jan 2023.
Kayumi, S., Pérez-Jurado, L.A., Palomares, M., Rangu, S., Sheppard, S.E., Chung, W.K., Kruer, M.C., Kharbanda, M., Amor, D.J., McGillivray, G., Cohen, J.S., García-Miñaúr, S., van Eyk, C.L., Harper, K., Jolly, L.A., Webber, D.L., Barnett, C.P., Santos-Simarro, F., Pacio-Míguez, M., del Pozo, A., Bakhtiari, S., Deardorff, M., Dubbs, H.A., Izumi, K., Grand, K., Gray, C., Mark, P.R., Bhoj, E.J., Li, D., Ortiz-Gonzalez, X.R., Keena, B., Zackai, E.H., Goldberg, E.M., Perez de Nanclares, G., Pereda, A., Llano-Rivas, I., Arroyo, I., Fernández-Cuesta, M.A., Thauvin-Robinet, C., Faivre, L., Garde, A., Mazel, B., Bruel, A.-L., Tress, M.L., Brilstra, E., Fine, A.S., Crompton, K.E., Stegmann, A.P.A., Sinnema, M., Stevens, S.C.J., Nicolai, J., Lesca, G., Lion-François, L., Haye, D., Chatron, N., Piton, A., Nizon, M., Cogne, B., Srivastava, S., Bassetti, J., Muss, C., Gripp, K.W., Procopio, R.A., Millan, F., Morrow, M.M., Assaf, M., Moreno-De-Luca, A., Joss, S., Hamilton, M.J., Bertoli, M., Foulds, N., McKee, S., MacLennan, A.H., Gecz, J., Corbett, M.: Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants. Genetics in Medicine 24(11): 2351-2366, November 2022.
Clatot, J., Parthasarathy., S, Cohen., S, McKee., J.L., Massey, S., Somarowthu, A., Goldberg, E.M. Helbig, I.: SCN1A gain-of-function mutation causing an early onset epileptic encephalopathy. Epilepsia Page: 1-3, October 2022 Notes: https://doi-org.proxy.library.upenn.edu/10.1111/epi.17444.
Goff, K.M., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron dysfunction underlies impaired neocortical state transitions and behavior in a model of Dravet syndrome (38) Poster presentation at the Gordon Research Conference: Mechanisms of Epilepsy and Neuronal Synchronization. Barcelona, Spain. July 2022.
Lawlor, P.N., Goldberg, E.M.: Dynamic fluorescence imaging in experimental epilepsy Epilepsy Currents 22(6), Jul 2022.
Kaneko, K., Currin, C.B., Goff, K.M., Somarowthu, A., Vogels, T.P., Goldberg, E.M.: Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. Cell Reports March 2022.
Schwarz, N., Seiffert, S., Pendziwiat, M., [...], Goldberg, E.M., Zara, F., Lal, D., May, P., Muhle, H., Helbig., I., Weber, Y.: Spectrum of phenotypic, genetic, and functional characteristics in epilepsy patients with KCNC2 pathogenic variants. Neurology March 2022.