1f
12
9
1a
8
20
8
49
16
8
19
1
49
2
8
1b
1d
18
79
3b
1d
2 29
1d
25
3b
Ethan M. Goldberg, M.D., Ph.D.
45Associate Professor of Neurology
28
97
3
60
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
8a
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
11
Department: Neurology
4
1
b
1d
46
Contact information
55
4
3
23
55
The Children's Hospital of Philadelphia
1d Division of Neurology
2b Abramson Research Center, Room 510D
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
26
1d Division of Neurology
2b Abramson Research Center, Room 510D
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
2e
Office: 215-590-6894
32 Fax: 215-590-1771
32 Lab: 215-590-5671
18
91
32 Fax: 215-590-1771
32 Lab: 215-590-5671
18
Email:
goldberge@email.chop.edu
12
goldberge@email.chop.edu
1f
Graduate Group Affiliations
8
3
1d
-
64
- Neuroscience e
18
Publications
23 a
3
2
29
23 a
Links
e1 Search PubMed for articles
95 Division of Neurology, The Children's Hospital of Philadelphia
5b Goldberg Lab Web Link
7a The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
c
4
b
1f
e1 Search PubMed for articles
95 Division of Neurology, The Children's Hospital of Philadelphia
5b Goldberg Lab Web Link
7a The Epilepsy Neurogenetics Initiative (ENGIN) Web Link
c
13
Education:
21 9 B.A. 19 (Neurobiology) c
2b Harvard University, 1999.
21 a Ph.D. 26 (Physiology & Neuroscience) c
3f New York University School of Medicine, 2006.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 2008.
21 a Cert. 6d (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER)) c
39 University of Wisconsin-Madison , 2022.
21 a Cert. 31 (Raising a Resilient Scientist Series) c
6d National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
c
3
3
21
21 9 B.A. 19 (Neurobiology) c
2b Harvard University, 1999.
21 a Ph.D. 26 (Physiology & Neuroscience) c
3f New York University School of Medicine, 2006.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 2008.
21 a Cert. 6d (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER)) c
39 University of Wisconsin-Madison , 2022.
21 a Cert. 31 (Raising a Resilient Scientist Series) c
6d National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
c
1f
Post-Graduate Training
24 5b Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
24 5d Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
24 95 Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
24 70 Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
c
3
25
24 5b Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
24 5d Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
24 95 Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
24 70 Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
c
17
Certifications
28 4a American Board of Psychiatry and Neurology (ABPN), 2013.
c
3
8d
Permanent link28 4a American Board of Psychiatry and Neurology (ABPN), 2013.
c
2 29
21
1e
1d
24
5e
71
e 29
27
Description of Clinical Expertise
8e Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.71
Description of Research Expertise
60 Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.e 29
23
134 Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.
181 Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. 50 bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 1e Jun 2025.
1c9 Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.
3a6 Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron 32 113(10): 1525-1547, May 2025.
1e5 Clatot, J., Thompson, C.H., Susan Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S.M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, Jr., A.L., Goldberg, E.M.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.
17b Wengert, E.R., Cheng, M.A., Liebergall, S.R., Markwalter, K.H., Hong, Y., Arias, L., Marsh, E.D., Zhang, X., Somarowthu, A., Goldberg, E.M.: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy. eLife 13(RP103784), December 2024 Notes: https://doi.org/10.7554/eLife.103784.1 14
10b Epi25 Collaborative.: Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes. Nat Neurosci 27(10): 1864-1879, Oct 2024.
a7 Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability 48 Epilepsy Currents 24(4): 286-288, Jul-Aug 2024.
164 Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, April 2024.
2c
7
1d
1f
Selected Publications
127 Sherer, M., Goldberg, E.M.: Flip of the Switch: Targeting GABA Dysregulation to Treat Nonseizure Comorbidities in Dravet Syndrome. Epilepsy Currents Nov 14 2025 Notes: Online ahead of print. doi: 10.1177/15357597251389967.134 Hill, S.F., Liebergall, S.L., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. J Neurophysiol 133(6): 1692-1698, Jun 2025.
181 Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. 50 bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 1e Jun 2025.
1c9 Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. Nat Commun 15((2_suppl)): 793S-822S, May 2025 Notes: doi.org/10.1101/2024.10.31.621357.
3a6 Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron 32 113(10): 1525-1547, May 2025.
1e5 Clatot, J., Thompson, C.H., Susan Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S.M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, Jr., A.L., Goldberg, E.M.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.
17b Wengert, E.R., Cheng, M.A., Liebergall, S.R., Markwalter, K.H., Hong, Y., Arias, L., Marsh, E.D., Zhang, X., Somarowthu, A., Goldberg, E.M.: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy. eLife 13(RP103784), December 2024 Notes: https://doi.org/10.7554/eLife.103784.1 14
10b Epi25 Collaborative.: Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes. Nat Neurosci 27(10): 1864-1879, Oct 2024.
a7 Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability 48 Epilepsy Currents 24(4): 286-288, Jul-Aug 2024.
164 Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, April 2024.
2c