Laura A Adang, M.D., PhD
Associate Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology
Contact information
The Children's Hospital of Philadelphia
3400 Civic Blvd.
Philadelphia, PA 19104
3400 Civic Blvd.
Philadelphia, PA 19104
Office: 215-590-1710
Email:
adangl@email.chop.edu
adangl@email.chop.edu
Education
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
Post-Graduate Training
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Certifications
American Board of Psychiatry and Neurology, 2014.
Permanent linkAmerican Board of Psychiatry and Neurology, 2014.
Description of Clinical Expertise
LeukodystrophiesDescription of Research Expertise
Clinical and biologic outcome measures in the leukodystrophiesSelected Publications
Videbaek CS, Kim DH, Hart HS, Thompson R, Aziz-Bose R, Purnell-Savoy L, Bharill S, Hashemi E, Orsini J, Seeger E, McAuliffe M, Srivastava I, MacLean JA, Shah S, Fatemi A, Cohen JS, Mallack E, Lund T, Eichler F, Bonkowsky JL, Adang L, He Z, Lund AM, van Haren KP.: Disease Outcomes in Boys with ABCD1 Variants Identified by Newborn Screening for X-ALD. medRxiv Jul 2026.Karandikar S, Sevagamoorthy A, Zimmerman D, D'Aiello R 3rd, Dorfschmidt L, Cyr K, Jung B, Levitis E, Adang LA, Arnold K, Bennett ML, Charsar BA, Dominguez Gonzalez CA, Gavazzi F, Hong P, Orthmann-Murphy JL, Pham ST, Kelley K, Lerner M, Shults J, Thakur N, Vossough A, Waldman AT, White A, Whitehead MT, Emrick L, Fraser J, Van Haren K, Keller S, Fatemi A, Eichler F, Bonkowsky JL; Global Leukodystrophy Initiative Clinical Trials Network Workgroup; Seidlitz J, Alexander-Bloch AF, Vanderver A.: Normative modeling for quantitative brain MRI phenotyping and biomarker discovery for pediatric leukodystrophies. medRxiv May 2026.
Cusack SV, Glanzman AM, Gavazzi F, Woidill S, Jawad AF, Estilow T, Waldman AT, Vanderver A, Adang L; Children's Hospital of Philadelphia Leukodystrophy Workgroup.: Performance outcomes of the PEDI-CAT for assessing functional ability in the population with leukodystrophy. Dev Med Child Neurol Apr 2026.
Calame DG, Wiener EK, Gavazzi F, Sevagamoorthy A, Pizzino A, Arnold K, Dominguez Gonzalez C, Jammihal T, Bennett M, Adang L, Woidill S, Whitehead MT, Vossough A, D'Aiello R, Takanohashi A, Lele J, Simons C, Rius R, Formaini E, Sullivan KE, Andzelm M, Ebrahimi-Fakhari D, Otten C, Wong S, Reynolds T, Schiffmann R, Wolf NI, Waisfisz Q, Niermeijer JM, DeMarzo D, Dawood M, Gandhi M, Levine JM, Chinn IK, Fisher K, Emrick L, Alam CA, Kaiyrzhanov R, Maroofian R, Houlden H, Jhangiani SN, Mehta HH, Muzny DM, Sedlazeck FJ, Posey JE, Lupski JR, Gibbs RA, Rajagopalan R, Vanderver A.: PTPN1-related autoinflammation is a common cause of Aicardi-Goutières Syndrome with reduced penetrance. medRxiv Apr 2026.
Sevagamoorthy A, Woidill S, Sudilovsky G, Kelley K, Vaia Y, Gavazzi F, Schmidt JL, Pizzino A, D'Aiello R, Uebergang E, Bruschi F, Mirchi A, Abe-Hatano C, Sartorelli J, Nicita F, Cunningham C, Tonduti D, Bertini E, Bernard G, Inoue K, Wolf NI, Adang LA, Shults J, Vanderver A.: Developmental trajectory of individuals with Pelizaeus-Merzbacher Disease (PMD). Mol Genet Metab 2026.
Sevagamoorthy A, Gavazzi F, Tashnim Z, Hong P, Vaia Y, Lee-Kirsch MA, Eleftheriou D, Beerepoot S, Hully M, Berry Kravis EM, Ventola P, Raspa M, Wheeler A, DeMauro SB, Glanzman AM, Townsend E, Duong T, Cusack S, Harrington AT, Pierce S, Fitzgerald M, Fazzi E, Galli J, Orcesi S, Tonduti D, Wassmer E, Cordova D, Adang LA, Butts C, Vanderver A.: A novel patient-Centered approach to clinical trial readiness in rare diseases: Application in Aicardi-Goutières Syndrome (AGS). Mol Genet Metab 2026.
Gavazzi F, Woidill S, Sevagamoorthy A, Jawad AF, D'Aiello R, Bradford J, Lerner M, Hong P, White A, Tashnim Z, Cusack SV, Glanzman AM, Harrington A, Waldman AT, Vanderver A, Adang LA.: Design of a Pediatric Low Motor Function Item Battery in leukodystrophies. Mol Genet Metab 2026.
Varesio C, Politano D, Adang L, Ballante E, Battini R, Bertini E, Borgatti R, De Giorgis V, Del Boca A, Dragoni F, Fazzi E, Galli J, Garau J, Gavazzi F, Gardani A, La Piana R, Moroni I, Nicita F, Pichiecchio A, Pini A, Ricci F, Sartori S, Tonduti D, Vanderver A, Orcesi S.: Clinical Characterization of a Multicenter International Cohort of Patients With Aicardi-Goutières Syndrome Homozygous for the RNASEH2B:p.Ala177Thr Variant: Early Clinical Markers of Disease Severity. Pediatric Neurology 171: 92-99, October 2025.
Asbreuk MABC, Schoenmakers DH, Adang LA, Beerepoot S, Bergner C, Bley A, Boelens JJ, Bugiani M, Calbi V, García-Cazorla À, Eklund EA, Fumagalli F, Grønborg SW, Groeschel S, Van Hasselt PM, Hollak CEM, Jones SA, de Koning TJ, van Kuilenburg ABP, Laugwitz L, Lindemans C, Mochel F, Øberg A, Ram D, Schöls L, Sevin C, Sinha J, Vaz FM, Zerem A, Wolf NI.: Metachromatic Leukodystrophy: New Therapy Advancements and Emerging Research Directions. Neurology 105(2): e213817, July 2025.
Mohajer A, Sevagamoorthy A, Bean K, Mutua S, Pang F, Adang LA.: Characterizing Diagnostic Delays in Metachromatic Leukodystrophy: A Real-World Data Approach. JIMD 48(4), July 2025.