Laura A Adang, M.D., PhD
Assistant Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology
Contact information
The Children's Hospital of Philadelphia
3400 Civic Blvd.
Philadelphia, PA 19104
3400 Civic Blvd.
Philadelphia, PA 19104
Office: 215-590-1710
Email:
adangl@email.chop.edu
adangl@email.chop.edu
Education:
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
Post-Graduate Training
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Certifications
American Board of Psychiatry and Neurology, 2014.
Permanent linkAmerican Board of Psychiatry and Neurology, 2014.
Description of Clinical Expertise
LeukodystrophiesDescription of Research Expertise
Clinical and biologic outcome measures in the leukodystrophiesSelected Publications
Cusack SV, Gavazzi F, de Barcelos IP, Modesti NB, Woidill S, Formanowski B, DeMauro SB, Lorch S, Vincent A, Jawad AF, Estilow T, Glanzman AM, Vanderver A, Adang LA.: Characterization of Fine Motor and Visual Motor Skills in Aicardi-Goutières Syndrome. J Child Neurol Mar 2024.Laugwitz L, Schoenmakers DH, Adang LA, Beck-Woedl S, Bergner C, Bernard G, Bley A, Boyer A, Calbi V, Dekker H, Eichler F, Eklund E, Fumagalli F, Gavazzi F, Grønborg SW, van Hasselt P, Langeveld M, Lindemans C, Mochel F, Oberg A, Ram D, Saunier-Vivar E, Schöls L, Scholz M, Sevin C, Zerem A, Wolf NI, Groeschel S.: Newborn screening in metachromatic leukodystrophy - European consensus-based recommendations on clinical management. Eur J Paediatr Neurol 49: 141-154, Mar 2024.
Adang LA, Sevagamoorthy A, Sherbini O, Fraser JL, Bonkowsky JL, Gavazzi F, D'Aiello R, Modesti NB, Yu E, Mutua S, Kotes E, Shults J, Vincent A, Emrick LT, Keller S, Van Haren KP, Woidill S, Barcelos I, Pizzino A, Schmidt JL, Eichler F, Fatemi A, Vanderver A.: Longitudinal natural history studies based on real-world data in rare diseases: Opportunity and a novel approach. Mol Genet Metab 142: 108453, Mar 2024.
Tricoli L, Sase S, Hacker J, Pham V, Smith S, Chappell M, Breda L, Hurwitz S, Tanaka N, Castracani CC, Guerra A, Hou Z, Schlotawa L, Radhakrishnan K, Kurre P, Ahrens-Nicklas R, Adang L, Vanderver A, Rivella S.: Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations. bioRxiv Mar 2024.
Gavazzi F, Gonzalez CD, Arnold K, Swantkowski M, Charlton L, Modesti N, Dar AA, Vanderver A, Bennett M, Adang LA.: Nucleotide metabolism, leukodystrophies, and CNS pathology. J Inherit Metab Dis Feb 2024.
Schoenmakers DH, Mochel F, Adang LA, Boelens JJ, Calbi V, Eklund EA, Grønborg SW, Fumagalli F, Groeschel S, Lindemans C, Sevin C, Schöls L, Ram D, Zerem A, Graessner H, Wolf NI.: Inventory of current practices regarding hematopoietic stem cell transplantation in metachromatic leukodystrophy in Europe and neighboring countries. Orphanet J Rare Dis 19: 46, Feb 2024.
de Barcelos IP, Woidill S, Gavazzi F, Modesti NB, Sevagamoorthy A, Vanderver A, Adang L.: Systematic analysis of genotype-phenotype variability in siblings with Aicardi Goutières Syndrome (AGS). Mol Genet Metab 142: 108346, Feb 2024.
Adang LA, Mowafy S, Herbst ZM, Zhou Z, Schlotawa L, Radhakrishnan K, Bentley B, Pham V, Yu E, Pillai NR, Orchard PJ, De Castro M, Vanderver A, Pasquali M, Gelb MH, Ahrens-Nicklas RC.: Biochemical signatures of disease severity in multiple sulfatase deficiency. J Inherit Metab Dis 2024.
Goldberg G, Coelho L, Mo G, Adang LA, Patne M, Chen Z, Garcia-Bassets I, Mesci P, Muotri AR.: TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids. Mol Psychiatry Dec 2023.
Adang LA, Mowafy S, Herbst ZM, Zhou Z, Schlotawa L, Radhakrishnan K, Bentley B, Pham V, Yu E, Pillai NR, Orchard PJ, De Castro M, Vanderver A, Pasquali M, Gelb MH, Ahrens-Nicklas RC.: Biochemical signatures of disease severity in Multiple Sulfatase Deficiency. JIMD Page: doi:0.1002/jimd.12688, October 2023.