Laura A Adang, M.D., PhD
Assistant Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology
Contact information
The Children's Hospital of Philadelphia
3400 Civic Blvd.
Philadelphia, PA 19104
3400 Civic Blvd.
Philadelphia, PA 19104
Office: 215-590-1710
Email:
adangl@email.chop.edu
adangl@email.chop.edu
Education:
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
BS (Interdisciplinary Studies: Neurology - Magna cum laude with Honors)
University of Georgia, 2001.
PhD (Microbiology)
University of Virginia, 2007.
MD
University of Virginia, 2009.
MS (Translational Research )
Penn, 2018.
Post-Graduate Training
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Pediatric Residency, The Children's Hospital of Philadelphia, 2009-2011.
Child Neurology Residency, The Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania, 2011-2014.
Multiple Sclerosis and Demyelinating Diseases Fellowship, The Children's Hospital of Philadelphia, 2015-2016.
Lysosomal Disease Network (LDN) research fellowship, CHOP, 2017-2018.
Certifications
American Board of Psychiatry and Neurology, 2014.
Permanent linkAmerican Board of Psychiatry and Neurology, 2014.
Description of Clinical Expertise
LeukodystrophiesDescription of Research Expertise
Clinical and biologic outcome measures in the leukodystrophiesSelected Publications
Varesio C, Politano D, Adang L, Ballante E, Battini R, Bertini E, Borgatti R, De Giorgis V, Del Boca A, Dragoni F, Fazzi E, Galli J, Garau J, Gavazzi F, Gardani A, La Piana R, Moroni I, Nicita F, Pichiecchio A, Pini A, Ricci F, Sartori S, Tonduti D, Vanderver A, Orcesi S.: Clinical Characterization of a Multicenter International Cohort of Patients With Aicardi-Goutières Syndrome Homozygous for the RNASEH2B:p.Ala177Thr Variant: Early Clinical Markers of Disease Severity. Pediatric Neurology 171: 92-99, October 2025.Asbreuk MABC, Schoenmakers DH, Adang LA, Beerepoot S, Bergner C, Bley A, Boelens JJ, Bugiani M, Calbi V, García-Cazorla À, Eklund EA, Fumagalli F, Grønborg SW, Groeschel S, Van Hasselt PM, Hollak CEM, Jones SA, de Koning TJ, van Kuilenburg ABP, Laugwitz L, Lindemans C, Mochel F, Øberg A, Ram D, Schöls L, Sevin C, Sinha J, Vaz FM, Zerem A, Wolf NI.: Metachromatic Leukodystrophy: New Therapy Advancements and Emerging Research Directions. Neurology 105(2), July 2025.
Kotes ER, Woidill S, D'Aiello R, Khan A, McCann J, Ramos M, Gavazzi F, Keller S, Van Haren K, Fatemi A, Eichler F, Bonkowsky J, Fraser J, Emrick L, Sherbini O, Hackett A, Gauna J, Amos D, Goodman J, Fine AS, Nagy A, Lee S, Page N, Schmidt J, Pizzino A, Muirhead K, Bennett M, Waldman A, Shults J, Adang L, Grundmeier R, Vanderver A.: Clinically Important Endpoints in Individuals With Leukodystrophy: A Multisite Study. Ann Child Neurol Soc July 2025.
Mohajer A, Sevagamoorthy A, Bean K, Mutua S, Pang F, Adang LA.: Characterizing Diagnostic Delays in Metachromatic Leukodystrophy: A Real-World Data Approach. JIMD 48(4), July 2025.
Gavazzi F, Martin A, Sevagamoorthy A, Vaia Y, Vincent A, Woidill S, D'Aiello R 3rd, DeMauro SB, Lorch SA, Vanderver A, Adang LA.: Experiences and Hope in Caregivers of Children With Aicardi Goutières Syndrome. J Child Neurology 22, May 2025.
Schoenmakers DH, Asbreuk MABC, Martin T, Datema M, Beerepoot S, Inbar-Feigenberg M, Groeschel S, Kehrer C, Øberg A, Sevin C, Fumagalli F, Bergner CG, Vieira P, Bley A, Uusimaa J, Horn MA, Brožová K, Stögmann E, Pichler H, Lüftinger R, Eklund EA, Mochel F, Adang LA, Laugwitz L, Boelens JJ, Calbi V, Darling A, García-Cazorla Á, Grønborg SW, Lindemans CA, van Hasselt PM, Hollak CEM, de Koning TJ, Ram D, Dekker H, Schöls L, Zerem A, Graessner H, Wolf NI.: Key lessons from the first international treatment eligibility committee: the case of metachromatic leukodystrophy. Eur J Paediatr Neurol 29(57): 72-81, May 2025.
Gavazzi F, Yu E, Tashnim Z, Woidill S, Sevagamoorthy A, Arnold K, Ammann-Schnell L, Groeschel S, Krägeloh-Mann I, Breitling V, Schlotawa L, Ahrens-Nicklas R, Adang LA.: Exploration Into Lived Experiences of Multiple Sulfatase Deficiency-Affected Individuals and Their Families. J. Child Neurology(14), May 2025.
Dominguez Gonzalez CA, Spinner NB, Ahrens-Nicklas RC, Young LR, Voss LA, Reichert SL, Gallo DJ, Cohen JS, Bonkowsky JL, Keller SR, Bennett ML, Pizzino AM, Swantkowski M, Arnold K, Fraser JL, Emerson FJ, Miettunen K, Fatemi A, Van Haren KP, Adang L, Waldman A, Emrick L, Eichler F, Vanderver A.: Reporting ABCD1 Variants as Actionable Secondary Findings on Exome and Genome Sequencing. Genet Med 5(101425), April 2025.
Gavazzi F, Charsar B, Hamilton E, Erler JA, Patel V, Woidill S, Sevagamoorthy A, Helman G, Schmidt J, Pizzino A, Muirhead K, Takanohashi A, Bonkowsky JL, Meyerhoffer K, Simons C, Doi H, Satoko M, Matsumoto N, Delgado MR, Sanchez-Castillo M, Wang J, de Carvalho DR, Tournev I, Chamova T, Jordanova A, Clegg NJ, Nicita F, Bertini E, Teng M, Williams D, Tonduti D, Houlden H, Stellingwerff M, Wassmer E, Garcia-Cazorla A, Bernard G, Mirchi A, Toutounchi H, Wolf NI, van der Knaap MS, Shults J, Adang LA, Vanderver AL.: The natural history of variable subtypes in pediatric-onset TUBB4A-related leukodystrophy. Mol Genet Metab 144(3), March 2025.
Kotes E, Gavazzi F, Woidill S, Sevagamoorthy A, Yang E, Smith V, Dubbs H, Pierce SR, Pucci K, Vithayathil J, Thakur N, Adang LA: Determination of Health Concepts in β-Propeller Protein-Associated Neurodegeneration. Journal of Child Neurology 40(1): 15-25, January 2025.