John A. Detre
Professor of Neurology
Director, Center for Functional Neuroimaging
Director, Brain Science Center
co-Director, Center for Advanced Magnetic Resonance Imaging and Spectroscopy
Department: Neurology
Contact information
3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104
Office: (215) 349-8465
Fax: (215) 614-1927
Fax: (215) 614-1927
Email:
DETRE@MAIL.MED.UPENN.EDU
DETRE@MAIL.MED.UPENN.EDU
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Brain Science Center website
Neuroscience graduate group faculty webpage.
Lab Website
Search PubMed for articles
Brain Science Center website
Neuroscience graduate group faculty webpage.
Lab Website
Education:
B.S. (Chemistry)
Yale University , 1981.
M.D.
Yale University, 1986.
B.S. (Chemistry)
Yale University , 1981.
M.D.
Yale University, 1986.
Post-Graduate Training
Intern in Medicine, University Health Ctr. of Pittsburgh, PA, 1986-1987.
Research Fellow, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 1987-1989.
Research Fellow, Department of Biochemistry/Biophysics, University of Pennsylvania, Philadelphia, PA, 1989-1990.
Resident in Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1993.
Intern in Medicine, University Health Ctr. of Pittsburgh, PA, 1986-1987.
Research Fellow, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 1987-1989.
Research Fellow, Department of Biochemistry/Biophysics, University of Pennsylvania, Philadelphia, PA, 1989-1990.
Resident in Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1993.
Certifications
American Board of Neurology and Psychiatry, 1994.
Permanent linkAmerican Board of Neurology and Psychiatry, 1994.
Description of Research Expertise
KEY WORDS:magnetic resonance, brain mapping, cerebral blood flow, brain injury
RESEARCH INTERESTS
Brain physiology and pathophysiology of functional activation. Clinical and translational neuroimaging.
RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.
RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, epilepsy, traumatic brain injury, aging, and dementia. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods.
Description of Clinical Expertise
headache, facial pain syndromes, strokeSelected Publications
Adebimpe, A., Bertolero, M., Dolui, S., Cieslak, M., Murtha, K., Baller, E. B., Boeve, B., Boxer, A., Butler, E. R., Cook, P., Colcombe, S., Covitz, S., Davatzikos, C., Davila, D. G., Elliott, M. A., Flounders, M. W., Franco, A. R., Gur, R. E., Gur, R. C., Jaber, B., McMillian, C., Allftd Consortium, Milham, M., Mutsaerts, Hjmm, Oathes, D. J., Olm, C. A., Phillips, J. S., Tackett, W., Roalf, D. R., Rosen, H., Tapera, T. M., Tisdall, M. D., Zhou, D., Esteban, O., Poldrack, R. A., Detre, J. A., Satterthwaite, T. D.: ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion. Nat Methods 19(6): 683-686, 2022.Kim, W. S. H., Luciw, N. J., Atwi, S., Shirzadi, Z., Dolui, S., Detre, J. A., Nasrallah, I. M., Swardfager, W., Bryan, R. N., Launer, L. J., MacIntosh, B. J.: Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy. Hum Brain Mapp 43(12): 3680-3693, 2022.
Jacobs, P. S., Benyard, B., Cember, A., Nanga, R. P. R., Cao, Q., Tisdall, M. D., Wilson, N., Das, S., Davis, K. A., Detre, J., Roalf, D., Reddy, R.: Repeatability of B1 (+) inhomogeneity correction of volumetric (3D) glutamate CEST via High-permittivity dielectric padding at 7T. Magn Reson Med 88(6): 2475-2484, 2022.
Hu, F., Weinstein, S. M., Baller, E. B., Valcarcel, A. M., Adebimpe, A., Raznahan, A., Roalf, D. R., Robert-Fitzgerald, T. E., Gonzenbach, V., Gur, R. C., Gur, R. E., Vandekar, S., Detre, J. A., Linn, K. A., Alexander-Bloch, A., Satterthwaite, T. D., Shinohara, R. T.: Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition. Hum Brain Mapp 43(15): 4650-4663, 2022.
Dolui, S., Detre, J. A., Gaussoin, S. A., Herrick, J. S., Wang, D. J. J., Tamura, M. K., Cho, M. E., Haley, W. E., Launer, L. J., Punzi, H. A., Rastogi, A., Still, C. H., Weiner, D. E., Wright, J. T., Jr., Williamson, J. D., Wright, C. B., Bryan, R. N., Bress, A. P., Pajewski, N. M., Nasrallah, I. M.: Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial. JAMA Neurol 79(4): 380-389, 2022.
Jiang, H., Simms, A. G., Sadaghiani, S., Jiang, Y. Y., Morgan, J. I. W., Aguirre, G. K., Pattany, P. M., Detre, J. A., Wang, J.: Multi-Center Repeatability of Macular Capillary Perfusion Density Using Optical Coherence Tomography Angiography. Clin Ophthalmol 16: 3069-3078, 2022.
Clement, P., Castellaro, M., Okell, T. W., Thomas, D. L., Vandemaele, P., Elgayar, S., Oliver-Taylor, A., Kirk, T., Woods, J. G., Vos, S. B., Kuijer, J. P. A., Achten, E., van Osch, M. J. P., Bids maintainers, Detre, J. A., Lu, H., Alsop, D. C., Chappell, M. A., Hernandez-Garcia, L., Petr, J., Mutsaerts, Hjmm: ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data 9(1): 543, 2022.
Cember, A. T. J., Wilson, N. E., Rich, L. J., Bagga, P., Nanga, R. P. R., Swago, S., Swain, A., Thakuri, D., Elliot, M., Schnall, M. D., Detre, J. A., Reddy, R.: Integrating (1)H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans. Neuroimage 251: 118977, 2022.
Bouhrara, M., Triebswetter, C., Kiely, M., Bilgel, M., Dolui, S., Erus, G., Meirelles, O., Bryan, N. R., Detre, J. A., Launer, L. J.: Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Netw Open 5(9): e2231189, 2022.
Baller, E. B., Valcarcel, A. M., Adebimpe, A., Alexander-Bloch, A., Cui, Z., Gur, R. C., Gur, R. E., Larsen, B. L., Linn, K. A., O'Donnell, C. M., Pines, A. R., Raznahan, A., Roalf, D. R., Sydnor, V. J., Tapera, T. M., Tisdall, M. D., Vandekar, S., Xia, C. H., Detre, J. A., Shinohara, R. T., Satterthwaite, T. D.: Developmental coupling of cerebral blood flow and fMRI fluctuations in youth. Cell Rep 38(13): 110576, 2022.