David John Irwin | Department of Neurology | Perelman School of Medicine at the University of Pennsylvania

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David John Irwin, MD, MTR

Associate Professor of Neurology

Member , Penn Institute for Translational Medicine and Therapeutics

Associate Fellow; Internal Advisory Board Member, Penn Institute on Aging

Co-Director, Penn Frontotemporal Degeneration Center

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Department: Neurology

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46 Contact information
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Hospital of the University of Pennsylvania
1f Department of Neurology
40 3400 Spruce Street, 3 W Gates
Philadelphia, Pa 19104

2e Office: 215-573-6417
32 Fax: 215-349-5579
32 Lab: 215-573-1912
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1f Graduate Group Affiliations 8

Neuroscience

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18 Publications
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26 Search PubMed for articles c

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Links
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72 Research Gate Profile
81 Google Scholar Profile
6f Irwin Lab Website
b6 PubMed Bibliography
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13 Education:
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28 Drew University, 2001.
21 7 MD c
3e Drexel University College of Medicine, 2006.
21 8 MTR c
4f University of Pennsylvania Perelman School of Medicine, 2015.
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1f Post-Graduate Training
24 52 Intern in Medicine, Hahnemann Hospital, Philadelphia, 2006-2007.
24 55 Resident in Neurology, Hahnemann Hospital, Philadelphia, 2007-2010.
24 5b Chief Resident in Neurology, Hahnemann Hospital, Philadelphia, 2009-2010.
24 93 Fellowship in Cognitive Neurology/Neurodegenerative Disease, Hospital of the University of Pennsylvania, Philadelphia, 2010-2014.
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17 Certifications
28 43 American Board of Psychiatry and Neurology, 2010.
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3 8d Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Clinical Expertise

1bc My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.
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Description of Other Expertise

60 Research Interests: Neuropathology and Biomarkers of Neurodegenerative Disease.
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104 Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
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188 Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
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213 Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
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100 Rotation projects: Quantification of neuron loss and gliosis in neurodegenerative disease, Distribution of TDP-43 pathology across the spectrum of ALS and FTLD-TDP, Distribution of tau and amyloid-beta in non-amnestic Alzheimer's disease patients.
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156 Lab Personnel: Claire Peterson- research assistant, Emily Xie- research assistant, Rebecca Lobrovich- research assistant, Lucia Giannini- visiting scholar, Daniel T Ohm- Postodctoral fellow, Sanaz Arezoumandan- Postdoctoral Fellow, Alejandra Bahena- Penn PURM researcher, Emily Kopp- Penn ITMAT Translational Research Program Intern \.
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Description of Research Expertise

431 The overall mission of my translational research program is to improve the diagnosis and treatment for young-onset and atypical neurodegenerative dementias. A major limitation for therapeutic trials in these disorders is that the gold-standard for diagnosis is neuropathological examination at autopsy. To address this problem, my lab (Penn Digital Neuropathology Lab) develops novel open-source digital image analysis tools to study gold-standard histopathology in an objective and reproducible manner with rigorous validation. My lab utilizes both innovative “wet-lab” human brain histology techniques and novel “dry-lab” digital image analysis methods and bioinformatics to integrate fine-grained measures of postmortem neuropathology with antemortem clincial data. My goal is to identify diagnostic and prognostic markers of disease progression that can serve as endpoints in treatment trials. The approach of my lab represents the blending of my training in two separate but complementary specialties of cognitive neurology and neuropathology.
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26 Last updated: 01/30/2026
34 The Trustees of the University of Pennsylvania c

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