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David John Irwin, MD

Assistant Professor of Neurology
Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Institute of Aging (Associate Fellow), University of Pennsylvania
Department: Neurology

Contact information
Hospital of the University of Pennsylvania
Department of Neurology
3400 Spruce Street, 3 W Gates
Philadelphia, Pa 19104
Graduate Group Affiliations
Drew University, 2001.
Drexel University College of Medicine, 2006.
University of Pennsylvania Perelman School of Medicine, 2015.
Post-Graduate Training
Intern in Medicine, Hahnemann Hospital, Philadelphia, 2006-2007.
Resident in Neurology, Hahnemann Hospital, Philadelphia, 2007-2010.
Chief Resident in Neurology, Hahnemann Hospital, Philadelphia, 2009-2010.
Fellowship in Cognitive Neurology/Neurodegenerative Disease, Hospital of the University of Pennsylvania, Philadelphia, 2010-2014.
American Board of Psychiatry and Neurology, 2010.
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Description of Clinical Expertise

My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.

Description of Other Expertise

Research Interests: Neuropathology of Neurodegenerative Disease.

Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.

Research Details: We use novel quantitative approach to histopathological studies to relate postmortem measures of disease to antemortem imaging and biofluid biomarkers to improve the antemortem diagnosis of neurodegenerative disease. Techniques and skills include neuropathology, gross anatomy and microanatomy, immunohistochemistry, digital image analysis, advanced patient classification statistics.

Rotation projects: Quantification of neuron loss and gliosis in neurodegenerative disease, Distribution of TDP-43 pathology across the spectrum of ALS and FTLD-TDP, Distribution of tau and amyloid-beta in non-amnestic Alzheimer's disease patients.

Lab Personnel: Claire Peterson- research assistant, Rebecca Lobrovich- research assistant, Lucia Giannini- visiting scholar, Dan Ohm- Postodctoral fellow, Alejandra Bahena- Penn PURM researcher.

Description of Research Expertise

My research program focuses on the interface of clinical symptoms and underlying neuropathology in neurodegenerative disease. The purpose of this approach is to better identify clinically, pathologically and genetically homogeneous patient populations for inclusion into clinical trials to efficiently study emerging disease modifying treatments that target the pathogenic proteins specific for each neuropathological subtype of disease (e.g. FTLD-associated with tau or TDP-43 protein inclusions).

Selected Publications

Irwin David J*, LleĆ³ Alberto, Xie Sharon X, McMillan Corey T, Wolk David A, Lee Edward B, Van Deerlin Viviana M, Shaw Leslie M, Trojanowski John Q, Grossman Murray: Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Annals of neurology 82(2): 247-258, Aug 2017 Notes: *Corresponding author.

Irwin David J*, Grossman Murray, Weintraub Daniel, Hurtig Howard I, Duda John E, Xie Sharon X, Lee Edward B, Van Deerlin Vivianna M, Lopez Oscar L, Kofler Julia K, Nelson Peter T, Jicha Gregory A, Woltjer Randy, Quinn Joseph F, Kaye Jeffery, Leverenz James B, Tsuang Debby, Longfellow Katelan, Yearout Dora, Kukull Walter, Keene C Dirk, Montine Thomas J, Zabetian Cyrus P, Trojanowski John Q: Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology 16(1): 55-65, Jan 2017 Notes: *Corresponding author.

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Last updated: 02/21/2020
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