David John Irwin, MD, MTR
Associate Professor of Neurology
Member , Penn Institute for Translational Medicine and Therapeutics
Associate Fellow; Internal Advisory Board Member, Penn Institute on Aging
Co-Director, Penn Frontotemporal Degeneration Center
Department: Neurology
Contact information
Hospital of the University of Pennsylvania
Department of Neurology
3400 Spruce Street, 3 W Gates
Philadelphia, Pa 19104
Department of Neurology
3400 Spruce Street, 3 W Gates
Philadelphia, Pa 19104
Office: 215-573-6417
Fax: 215-349-5579
Lab: 215-573-1912
Fax: 215-349-5579
Lab: 215-573-1912
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Research Gate Profile
Irwin Lab Website
PubMed Bibliography
Google Scholar Profile
Search PubMed for articles
Research Gate Profile
Irwin Lab Website
PubMed Bibliography
Google Scholar Profile
Education:
BA
Drew University, 2001.
MD
Drexel University College of Medicine, 2006.
MTR
University of Pennsylvania Perelman School of Medicine, 2015.
BA
Drew University, 2001.
MD
Drexel University College of Medicine, 2006.
MTR
University of Pennsylvania Perelman School of Medicine, 2015.
Post-Graduate Training
Intern in Medicine, Hahnemann Hospital, Philadelphia, 2006-2007.
Resident in Neurology, Hahnemann Hospital, Philadelphia, 2007-2010.
Chief Resident in Neurology, Hahnemann Hospital, Philadelphia, 2009-2010.
Fellowship in Cognitive Neurology/Neurodegenerative Disease, Hospital of the University of Pennsylvania, Philadelphia, 2010-2014.
Intern in Medicine, Hahnemann Hospital, Philadelphia, 2006-2007.
Resident in Neurology, Hahnemann Hospital, Philadelphia, 2007-2010.
Chief Resident in Neurology, Hahnemann Hospital, Philadelphia, 2009-2010.
Fellowship in Cognitive Neurology/Neurodegenerative Disease, Hospital of the University of Pennsylvania, Philadelphia, 2010-2014.
Certifications
American Board of Psychiatry and Neurology, 2010.
Permanent linkAmerican Board of Psychiatry and Neurology, 2010.
Description of Clinical Expertise
My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.Description of Other Expertise
Research Interests: Neuropathology and Biomarkers of Neurodegenerative Disease.Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Rotation projects: Quantification of neuron loss and gliosis in neurodegenerative disease, Distribution of TDP-43 pathology across the spectrum of ALS and FTLD-TDP, Distribution of tau and amyloid-beta in non-amnestic Alzheimer's disease patients.
Lab Personnel: Claire Peterson- research assistant, Emily Xie- research assistant, Rebecca Lobrovich- research assistant, Lucia Giannini- visiting scholar, Daniel T Ohm- Postodctoral fellow, Sanaz Arezoumandan- Postdoctoral Fellow, Alejandra Bahena- Penn PURM researcher, Emily Kopp- Penn ITMAT Translational Research Program Intern \.