faculty photo

Matthew K Schindler, MD, PhD

Assistant Professor of Neurology at the Pennsylvania Hospital
Assistant Professor, Department of Neurology, University of Pennsylvania
Department: Neurology

Contact information
Department of Neurology
3 West Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 2156623606
BA (Philosophy - Neuroscience - Cognitive Psychology)
Washington University, 2001.
MD/PhD (Neuroscience)
Wake Forest University School of Medicine, 2010.
Post-Graduate Training
Intern - Internal Medicine, Yale - New Haven Hospital, 2010-2011.
Resident in Neurology, University of Pennsylvania, 2011-2014.
Neuroimmunology Fellow, National Institute of Neurological Disorders and Stroke, Translational Neuroradiology Section, 2014-2018.
NRSA T32 Fellow, Department of Neurology, University of Pennsylvania, 2018-2019.
Master's in Translational Research, University of Pennsylvania, Institute for Translational Medicine and Therapeutics, 2019-2021.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Multiple Sclerosis, Neuroinflammatory Diseases

Description of Research Expertise

MRI, Ultra high-field (7T) MRI, Neuroinflammation

Selected Publications

Ian Z. Ong, Dennis L. Kolson, Matthew K. Schindler: Mechanisms, Effects, and Management of Neurological Complications of Post-acute Sequelae of COVID-19 (NC-PASC). Biomedicines 11(2), Feb 2023.

Abby Manning, Erin S. Beck, Matthew K. Schindler, Daniel S. Reich, Russell T. Shinohara, Andrew J. Solomon: T1/ T2 Ratio from 3T MRI Improves Multiple Sclerosis Cortical Lesion Contrast. J Neuroimaging 2023.

Raghav R Mattay, Karapet Davtyan, Jeffrey D Rudie, Govind S Mattay, Dina A Jacobs, Matthew Schindler, Laurie A Loevner, Mitchell D Schnall, Michel Bilello, Alexander C Mamourian, Tessa S Cook: Economic impact of selective use of contrast for routine follow-up MRI of patients with multiple sclerosis. J Neuroimaging Mar 2022.

Hu M, Crainiceanu C, Schindler MK, Dewey B, Reich DS, Shinohara RT, Eloyan A: Matrix decomposition for modeling lesion development processes in multiple sclerosis. Biostatistics Jan 2022.

Carolyn Lou, Pascal Sati, Martina Absinta, Kelly Clark, Jordan D. Dworkin, Alessandra M. Valcarcel, Matthew K. Schindler, Daniel S. Reich, Elizabeth M. Sweeney, Russell T. Shinohara: Fully automated detection of paramagnetic rims in multiple sclerosis lesions on 3T susceptibility-based MR imaging NeuroImage: Clinical 2021.

Lynn Daboul, Carly M. O’Donnell, Quy Cao, David Moreno-Dominguez, Paulo Rodrigues, John Derbyshire, Christina Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter Calabresi, Bruce A.C. Cree, Leorah Freeman, Roland G. Henry, Erin E. Longbrake, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D. Samudralwar, Suradech Suthiphosuwan, Matthew K. Schindler, Elias S. Sotirchos, Nancy L. Sicotte, Andrew J. Solomon, Russell T. Shinohara, Daniel S. Reich, Daniel Ontaneda, Pascal Sati: Gadolinium Improves Detection of Central Vein Lesions in MS Using 3T FLAIR* AJNR. American Journal of Neuroradiology 2021.

Thomas Campbell Arnold; Danni Tu; Serhat V. Okar; Govind Nair; Samantha By; Karan D. Kawatra; Timothy E. Robert-Fitzgerald; Lisa M. Desiderio; Matthew K. Schindler; Russell T. Shinohara; Daniel S. Reich; Joel M. Stein: Sensitivity of Portable Low-Field Magnetic Resonance Imaging for Multiple Sclerosis Lesions. Neuroimage: Clinical 2021.

Ontaneda D, Sati P, Raza P, Kilbane M, Gombos E, Alvarez E, Azevedo C, Calabresi P, Cohen JA, Freeman L, Henry RG, Longbrake EE, Mitra N, Illenberger N, Schindler M, Moreno-Dominguez D, Ramos M, Mowry E, Oh J, Rodrigues P, Chahin S, Kaisey M, Waubant E, Cutter G, Shinohara R, Reich DS, Solomon A, Sicotte NL: Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial. Neuroimage: Clinical Sept 2021.

Irene Cortese, Erin S. Beck, Omar Al-Louzi, Joan Ohayon, Frances Andrada, Ikesinachi Osuorah, Jen Dwyer, B. Jeanne Billioux, Nigar Dargah-zada, Matthew K. Schindler, Kyle Binder, Lauren Reoma, Gina Norato, Yoshimi Enose-Akahata, Bryan Smith, Maria Chiara Monaco, Eugene O. Major, Steve Jacobson, David Stroncek, Steven Highfill, Sandhya Panch, Daniel S. Reich, John Barrett, Avindra Nath, Pawel Muranski: BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot study. Lancet Neurology Aug 2021 Notes: in-press.

Rudie Jeffrey D, Mattay Raghav R, Schindler Matthew, Steingall Samantha, Cook Tessa S, Loevner Laurie A, Schnall Mitchell D, Mamourian Alexander C, Bilello Michel: An Initiative to Reduce Unnecessary Gadolinium-Based Contrast in Multiple Sclerosis Patients. Journal of the American College of Radiology : JACR 16(9 Pt A): 1158-1164, Sep 2019.

Cortese Irene, Muranski Pawel, Enose-Akahata Yoshimi, Ha Seung-Kwon, Smith Bryan, Monaco MariaChiara, Ryschkewitsch Caroline, Major Eugene O, Ohayon Joan, Schindler Matthew K, Beck Erin, Reoma Lauren B, Jacobson Steve, Reich Daniel S, Nath Avindra: Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. The New England journal of medicine 380(17): 1597-1605, Apr 2019.

Schindler Matthew K, Sati Pascal, Reich Daniel S: Insights from Ultrahigh Field Imaging in Multiple Sclerosis. Neuroimaging clinics of North America 27(2): 357-366, May 2017.

Schindler MK, Pittaluga S, Enose-Akahata Y, Su HC, Rao VK, Rump A, Jacobson S, Cortese I, Reich DS, Uzel G: Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder. Journal of Clinical Investigation 130(10): 5551-5561, Oct 2020.

Valcarcel AM, Muschelli J, Pham DL, Martin ML, Yushkevich P, Brandstadter R, Patterson KR, Schindler MK, Calabresi PA, Bakshi R, Shinohara RT : TAPAS: A threshold approach for probability map automatic segmentation in multiple sclerosis. Neuroimage. Clinical 27: 102256, 2020 Notes: Epub 2020 May.

back to top
Last updated: 11/20/2023
The Trustees of the University of Pennsylvania