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Delia Maria Talos, MD
4eResearch Associate Professor of Neurology
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Co-Director, Penn Epilepsy Biobank
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Department: Neurology
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Contact information
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University of Pennsylvania
23 Perelman School of Medicine
26 263 Clinical Research Building
36 415 Curie Boulevard
Philadelphia, PA 19104
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23 Perelman School of Medicine
26 263 Clinical Research Building
36 415 Curie Boulevard
Philadelphia, PA 19104
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Office: 215-573-8328
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32 Fax: 215-662-3362
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Graduate Group Affiliations
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- Neuroscience e
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Education:
21 7 MD 15 (Medicine) c
37 University of Cologne, Germany, 1992.
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21 7 MD 15 (Medicine) c
37 University of Cologne, Germany, 1992.
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Post-Graduate Training
24 71 Resident in Surgery, Clinic for Surgery and Reconstructive Surgery, Aachen, Germany, 1994-1996.
24 61 Research Fellow in Neurophysiology, University of Muenster, Germany, 1998-2000.
24 73 Research Fellow in Neurology and Neuroscience, Boston Children's Hospital, Boston, MA, 2001-2006.
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Permanent link24 71 Resident in Surgery, Clinic for Surgery and Reconstructive Surgery, Aachen, Germany, 1994-1996.
24 61 Research Fellow in Neurophysiology, University of Muenster, Germany, 1998-2000.
24 73 Research Fellow in Neurology and Neuroscience, Boston Children's Hospital, Boston, MA, 2001-2006.
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6f 2) Research interests: Neuronal and glial development, synaptic function, epilepsy, autism, cognition.
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ab 3) Research techniques: Quantitative protein and gene expression, immunohistochemistry, fluorescence microscopy, transgenic animals, EEG recordings, mouse behavior
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236 4) Research summary: My research focuses on understanding the cellular and molecular mechanisms of epilepsy and its associated neuropsychiatric co-morbidities, with a particular emphasis on genetic, immunological and neurodegenerative processes. The laboratory uses both human brain samples and translational mouse models to study and treat genetic epilepsies such as Tuberous Sclerosis Complex and CDKL5 deficiency disorder, as well as more common forms of epilepsy, caused by status epilepticus, traumatic brain injury and neurodegenerative brain disorders.
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Description of Research Expertise
53 1) Key words: epilepsy, neurodevelopment, aging, neuroinflammation8
6f 2) Research interests: Neuronal and glial development, synaptic function, epilepsy, autism, cognition.
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236 4) Research summary: My research focuses on understanding the cellular and molecular mechanisms of epilepsy and its associated neuropsychiatric co-morbidities, with a particular emphasis on genetic, immunological and neurodegenerative processes. The laboratory uses both human brain samples and translational mouse models to study and treat genetic epilepsies such as Tuberous Sclerosis Complex and CDKL5 deficiency disorder, as well as more common forms of epilepsy, caused by status epilepticus, traumatic brain injury and neurodegenerative brain disorders.
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182 Fukushima K, Higashiyama H, Kazuta Y, Hashimoto K, Watanabe N, Furuya Y, Ito Y, Wu T, Kosasa T, Talos DM, Song Y, Roberts NS, Jensen FE, Hanada T, Ido K: Discovery of E2730, a novel selective uncompetitive GAT1 inhibitor, as a candidate for anti-seizure medication. Epilepsia Open Online ahead of print, Apr 2023.
154 Barbour AJ, Gourmaud S, Li X, Stewart D, Irwin DJ, Talos DM, Jensen FE : Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease with attenuation after rapamycin treatment. bioRxiv Mar 2023 Notes: doi: https://doi.org/10.1101/2023.03.02.530499.
14c Juul HM, Brooks-Kayal AR, Talos DM: Why do febrile seizures involve specifically the developing brain? Febrile Seizures, 2nd edition. Tallie Z. Baram, Shlomo Shinnar and Carl E. Stafstrom (eds.). UK: Academic Press, Page: 155-178, Sept 2022 Notes: Chapter 9.
159 Xu HN*, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM*, Li LZ*: Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer's Disease. Metabolites 12(9): 786, Aug 2022 Notes: *Equal contribution.
14d Gourmaud S, Stewart DA, Irwin DJ, Roberts NS, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos* DM, Jensen FJ*: The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain 145(1): 324-339, Mar 2022 Notes: *Equal contribution.
f1 Xu HN, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM, Li LZ: Optical redox imaging of ex vivo hippocampal slices differentiates normal from Alzheimer’s disease in mouse models 2 69 World Molecular Imaging Congress, Miami Beach, FL 2022 Notes: Oral presentation.
11e Juul H, Sansalone KA, Chen I, Talos DM: Selective metabolic alterations in therapy resistant temporal lobe epilepsy. American Epilepsy Society Meeting, Nashville, TN. Abstract Viewer Abst 3.099 2022 Notes: Poster.
5a Xing B, Babrowicz B, Li X, Talos DM, Jensen FE df : Tracking the evolution of synaptic dysplasticity after early life seizures. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No 038.05. Online 2022 Notes: Poster.
148 Rodemer W, Juul H, Mehta S, Farag M, Porta S, Talos DM, Lee VM-Y: Seizures in a doxycycline-regulatable mouse model of TDP-43 proteinopathy. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No 537.03. Online 2022 Notes: Poster.
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Selected Publications
10d Roberts NS, Handy MJ, Ito Y, Hashimoto K, Jensen FE, Talos DM: Anti-seizure efficacy of perampanel in two established rodent models of early-life epilepsy. Epilepsy Behavior 143: 109194, Jun 2023.182 Fukushima K, Higashiyama H, Kazuta Y, Hashimoto K, Watanabe N, Furuya Y, Ito Y, Wu T, Kosasa T, Talos DM, Song Y, Roberts NS, Jensen FE, Hanada T, Ido K: Discovery of E2730, a novel selective uncompetitive GAT1 inhibitor, as a candidate for anti-seizure medication. Epilepsia Open Online ahead of print, Apr 2023.
154 Barbour AJ, Gourmaud S, Li X, Stewart D, Irwin DJ, Talos DM, Jensen FE : Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease with attenuation after rapamycin treatment. bioRxiv Mar 2023 Notes: doi: https://doi.org/10.1101/2023.03.02.530499.
14c Juul HM, Brooks-Kayal AR, Talos DM: Why do febrile seizures involve specifically the developing brain? Febrile Seizures, 2nd edition. Tallie Z. Baram, Shlomo Shinnar and Carl E. Stafstrom (eds.). UK: Academic Press, Page: 155-178, Sept 2022 Notes: Chapter 9.
159 Xu HN*, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM*, Li LZ*: Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer's Disease. Metabolites 12(9): 786, Aug 2022 Notes: *Equal contribution.
14d Gourmaud S, Stewart DA, Irwin DJ, Roberts NS, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos* DM, Jensen FJ*: The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain 145(1): 324-339, Mar 2022 Notes: *Equal contribution.
f1 Xu HN, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM, Li LZ: Optical redox imaging of ex vivo hippocampal slices differentiates normal from Alzheimer’s disease in mouse models 2 69 World Molecular Imaging Congress, Miami Beach, FL 2022 Notes: Oral presentation.
11e Juul H, Sansalone KA, Chen I, Talos DM: Selective metabolic alterations in therapy resistant temporal lobe epilepsy. American Epilepsy Society Meeting, Nashville, TN. Abstract Viewer Abst 3.099 2022 Notes: Poster.
5a Xing B, Babrowicz B, Li X, Talos DM, Jensen FE df : Tracking the evolution of synaptic dysplasticity after early life seizures. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No 038.05. Online 2022 Notes: Poster.
148 Rodemer W, Juul H, Mehta S, Farag M, Porta S, Talos DM, Lee VM-Y: Seizures in a doxycycline-regulatable mouse model of TDP-43 proteinopathy. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No 537.03. Online 2022 Notes: Poster.
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