faculty photo

Pedro Gonzalez-Alegre, MD, PhD

Associate Professor of Neurology at the Pennsylvania Hospital
Co-Director, Clinical Programs, Raymond G. Perelman Center for Molecular & Cellular Therapy Children Hospital of Philadelphia
Director, Neurogenetics Program Department of Neurology The University of Pennsylvania
Director, Huntington's Disease Center of Excellence Department of Neurology The University of Pennsylvania
Co-Director, Division of Movement Disorders Department of Neurology The University of Pennsylvania
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
800 Spruce Street
Philadelphia, PA 19107
University of Malaga Medical School, Málaga (Spain), 1996.
PhD (Neuroscience)
University of Malaga Medical School, Málaga (Spain), 2009.
Post-Graduate Training
Intern, Department of Medicine, Saint Vincent Hospital, 1998-1999.
Resident, Department of Neurology, University of Iowa , 1999-2002.
Fellow, Movement Disorders/Neurogenetics, University of Iowa , 2002-2004.
Educational Commission for Foreign Medical Graduates, 1997.
American Board of Psychiatry and Neurology (recertification March 2013), 2003.
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Selected Publications

Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P.: Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo. Brain Research Oct 2018.

Hitti FL, Gonzalez-Alegre P, Lucas TH.: Gene Therapy for Neurological Disease: A Neurosurgical Review. World Neurosurgery Sep 2018.

Schultz JL, Nopoulos PC, Gonzalez-Alegre P.: Human Immunodeficiency Virus Infection in Huntington's Disease is Associated with an Earlier Age of Symptom Onset. Journal of Huntington's Disease 7(2): 163-166, Jun 2018.

Bardakjian TM, Helbig I, Quinn C, Elman LB, McCluskey LF, Scherer SS, Gonzalez-Alegre P.: Genetic test utilization and diagnostic yield in adult patients with neurological disorders. Neurogenetics 19(2): 105-110, May 2018.

Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P and Ehrlich ME: Mutations in THAP1/DYT6 Reveal that Diverse Dystonia Genes Disrupt Similar Neuronal Pathways and Functions. PLoS Genetics Jan 2018.

Bardakjian T, Gonzalez-Alegre P.: Towards precision medicine. Handb Clin Neurol 147: 93-102, Jan 2018.

Beauvais Genevieve, Rodriguez-Losada Noela, Ying Lei, Zakirova Zuchra, Watson Jaime L, Readhead Ben, Gadue Paul, French Deborah L, Ehrlich Michelle E, Gonzalez-Alegre Pedro: Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience Dec 2017.

Aguilo Francesca, Zakirova Zuchra, Nolan Katie, Wagner Ryan, Sharma Rajal, Hogan Megan, Wei Chengguo, Sun Yifei, Walsh Martin J, Kelley Kevin, Zhang Weijia, Ozelius Laurie J, Gonzalez-Alegre Pedro, Zwaka Thomas P, Ehrlich Michelle E: THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem cell reports 9(1): 92-107, Jul 2017.

Reichert Sara Chadwick, Gonzalez-Alegre Pedro, Scharer Gunter H: Biallelic TOR1A variants in an infant with severe arthrogryposis. Neurology. Genetics 3(3): e154, Jun 2017.

Lee Jessica K, Ding Yue, Conrad Amy L, Cattaneo Elena, Epping Eric, Mathews Kathy, Gonzalez-Alegre Pedro, Cahill Larry, Magnotta Vincent, Schlaggar Bradley L, Perlmutter Joel S, Kim Regina E Y, Dawson Jeffrey D, Nopoulos Peg: Sex-specific effects of the Huntington gene on normal neurodevelopment. Journal of neuroscience research 95(1-2): 398-408, Jan 2017.

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Last updated: 11/01/2018
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