faculty photo

Pedro Gonzalez-Alegre, MD, PhD

Associate Professor of Neurology at the Pennsylvania Hospital
Co-Director, Clinical Programs, Raymond G. Perelman Center for Molecular & Cellular Therapy Children Hospital of Philadelphia
Director, Neurogenetics Program Department of Neurology The University of Pennsylvania
Director, Huntington's Disease Center of Excellence Department of Neurology The University of Pennsylvania
Co-Director, Division of Movement Disorders Department of Neurology The University of Pennsylvania
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
800 Spruce Street
Philadelphia, PA 19107
University of Malaga Medical School, Málaga (Spain), 1996.
PhD (Neuroscience)
University of Malaga Medical School, Málaga (Spain), 2009.
Post-Graduate Training
Intern, Department of Medicine, Saint Vincent Hospital, 1998-1999.
Resident, Department of Neurology, University of Iowa , 1999-2002.
Fellow, Movement Disorders/Neurogenetics, University of Iowa , 2002-2004.
Educational Commission for Foreign Medical Graduates, 1997.
American Board of Psychiatry and Neurology (recertification March 2013), 2003.
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Selected Publications

Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P and Ehrlich ME: Mutations in THAP1/DYT6 Reveal that Diverse Dystonia Genes Disrupt Similar Neuronal Pathways and Functions. PLoS Genetics 2018.

Beauvais Genevieve, Rodriguez-Losada Noela, Ying Lei, Zakirova Zuchra, Watson Jaime L, Readhead Ben, Gadue Paul, French Deborah L, Ehrlich Michelle E, Gonzalez-Alegre Pedro: Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience Dec 2017.

Aguilo Francesca, Zakirova Zuchra, Nolan Katie, Wagner Ryan, Sharma Rajal, Hogan Megan, Wei Chengguo, Sun Yifei, Walsh Martin J, Kelley Kevin, Zhang Weijia, Ozelius Laurie J, Gonzalez-Alegre Pedro, Zwaka Thomas P, Ehrlich Michelle E: THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem cell reports 9(1): 92-107, Jul 2017.

Reichert Sara Chadwick, Gonzalez-Alegre Pedro, Scharer Gunter H: Biallelic TOR1A variants in an infant with severe arthrogryposis. Neurology. Genetics 3(3): e154, Jun 2017.

Lee Jessica K, Ding Yue, Conrad Amy L, Cattaneo Elena, Epping Eric, Mathews Kathy, Gonzalez-Alegre Pedro, Cahill Larry, Magnotta Vincent, Schlaggar Bradley L, Perlmutter Joel S, Kim Regina E Y, Dawson Jeffrey D, Nopoulos Peg: Sex-specific effects of the Huntington gene on normal neurodevelopment. Journal of neuroscience research 95(1-2): 398-408, Jan 2017.

Mendizabal A, Vu AT, Thibault D, Gonzalez-Alegre P, Willis A.: Hospitalizations of Children with Huntington disease in the United States. Mov Disord Clin Pract 4(5), 2017.

Keiser Megan S, Monteys Alejandro Mas, Corbau Romuald, Gonzalez-Alegre Pedro, Davidson Beverly L: RNAi prevents and reverses phenotypes induced by mutant human ataxin-1. Annals of neurology 80(5): 754-765, Nov 2016.

Beauvais Genevieve, Bode Nicole M, Watson Jaime L, Wen Hsiang, Glenn Kevin A, Kawano Hiroyuki, Harata N Charles, Ehrlich Michelle E, Gonzalez-Alegre Pedro: Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience 36(40): 10245-10256, Oct 2016.

García-Casares Natalia, García-Arnés Juan A, Rioja Jose, Ariza María José, Gutiérrez Antonio, Alfaro Francisco, Nabrozidis Alejandro, González-Alegre Pedro, González-Santos Pedro: Alzheimer's like brain changes correlate with low adiponectin plasma levels in type 2 diabetic patients. Journal of diabetes and its complications 30(2): 281-6, Mar 2016.

Klionsky et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1): 1-222, 2016.

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Last updated: 01/10/2018
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