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Denise J Xu, MD
4eAssistant Professor of Clinical Neurology
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Assistant Program Director, Neurology Residency, University of Pennsylvania
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Director for the Neurology Sub-I, University of Pennsylvania, Perelman School of Medicine
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Penn PORTAL Clinician Leader, University of Pennsylvania
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Department: Neurology
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Contact information
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Hospital of the University of Pennsylvania
35 3400 Spruce Street
Philadelphia, PA 19104
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35 3400 Spruce Street
Philadelphia, PA 19104
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Education:
21 7 BA 5c (Bachelor of Arts in Neurobiology, Magna Cum Laude, Citation in Mandarin Chinese) c
37 Harvard College, Cambridge, MA, 2011.
21 7 MD 3d (Medical Doctor, Certificate in Medical Education) c
56 Perelman School of Medicine at the University of Pennsylvania, 2018.
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21 7 BA 5c (Bachelor of Arts in Neurobiology, Magna Cum Laude, Citation in Mandarin Chinese) c
37 Harvard College, Cambridge, MA, 2011.
21 7 MD 3d (Medical Doctor, Certificate in Medical Education) c
56 Perelman School of Medicine at the University of Pennsylvania, 2018.
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Post-Graduate Training
24 73 Preliminary Year, Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 2018-2019.
24 5f Neurology Residency, University of Pennsylvania, Philadelphia, PA, 2019-2022.
24 66 Neurohospitalist Fellowship, University of California, San Francisco, CA, 2022-2023.
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Permanent link24 73 Preliminary Year, Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 2018-2019.
24 5f Neurology Residency, University of Pennsylvania, Philadelphia, PA, 2019-2022.
24 66 Neurohospitalist Fellowship, University of California, San Francisco, CA, 2022-2023.
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Description of Clinical Expertise
23 Inpatient neurology62
Description of Other Expertise
60 Undergraduate medical education, graduate medical education, quality improvement1a 29
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105 Rock M, Shipley SC, Little JN, Berger J, Xu DJ: Clinical Reasoning: A 60-Year-Old Man with Rapidly Progressive Left Hemibody Weakness and Vision Loss. Neurology 105(2): e213869, July 2025.
106 Xu D, Cristancho D, Price R: Expanding the Inpatient General Neurology Consultation Service: An Initiative to Improve Care Delivery. American Academy of Neurology, San Diego, CA April 2025.
143 Liu P, Napole A, Denison L, Shaik N, Venezia G, Ljungberg L, Karamardian M, Peachey C, Buckley M, Bae C, Stein L, Xu D, Ellis C: Are Routine Overnight Vitals Necessary for Neurology Inpatients? American Academy of Neurology, San Diego, CA April 2025.
126 Little J, Shipley S, Rock M, Berger JR, Xu DJ: Paraneoplastic Tumefactive Demyelination with Anti-LUZP4 Antibody Associated with Metastatic Seminoma: A Case Report. American Academy of Neurology, San Diego, CA April 2025.
1c8 Shaik NF, Denison L, Venezia GMA, Ljungberg L, Lebrón-Cruz A, Resnick D, Peachey C, Ziemba C, Buckley M, Karamardian M, Liu PZ, Napole A, Hong J, Zeng R, Yu C, Chan A, Bae C, Stein L, Ellis CA, Xu DJ: Improving sleep on the inpatient general, non-stroke neurology service: a quasi-experimental interventional trial Journal of Hospital Medicine 2025 Notes: Accepted for publication.
12c Eisinger RS, Jones FJ, Pai EL, Xu D, Berger JR, Prasad S: Ideomotor Apraxia and 'Milky Way' Sign in Progressive Multifocal Leukoencephalopathy. Neurology 103(10): e209938, November 2024 Notes: DOI: 10.1212/WNL.0000000000209938.
146 Karamardian M, Stein L, Resnick D, Chambers C, Peachey C, Malinovitch A, Rosin R, Bae C, Buckley M, Xu DJ: Restoring Sleep for Neurology Inpatients. American Academy of Neurology, Denver, CO April 2024 Notes: Platform presentation and accepted abstract.
14e Lebron-Cruz A, Liu P, Venezia G, Ljungberg L, Peachey C, Buckley M, Karamardian M, Xu DJ, Bae C, Stein L, Ellis C: Characterizing Inpatient Sleep on the Neurology Service. American Academy of Neurology, Denver, CO April 2024 Notes: Poster and accepted abstract.
bb Douglas AG, Xu DJ, Shah MP: Approach to Myelopathy and Myelitis. Neurologic Clinics 40(1): 133-156, February 2022.
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Selected Publications
15f Ellis CA, Liu PZ, Napole A, Denison L, Shaik NF, Venezia GA, Ljungberg L, Karamardian MA, Peachey C, Buckley M, Bae CJ, Stein L, Xu DJ: Promoting Sleep for Neurology Inpatients: The Value of Routine Overnight Vital Signs. Neurology Clinical Practice 15(4): e200492, August 2025.105 Rock M, Shipley SC, Little JN, Berger J, Xu DJ: Clinical Reasoning: A 60-Year-Old Man with Rapidly Progressive Left Hemibody Weakness and Vision Loss. Neurology 105(2): e213869, July 2025.
106 Xu D, Cristancho D, Price R: Expanding the Inpatient General Neurology Consultation Service: An Initiative to Improve Care Delivery. American Academy of Neurology, San Diego, CA April 2025.
143 Liu P, Napole A, Denison L, Shaik N, Venezia G, Ljungberg L, Karamardian M, Peachey C, Buckley M, Bae C, Stein L, Xu D, Ellis C: Are Routine Overnight Vitals Necessary for Neurology Inpatients? American Academy of Neurology, San Diego, CA April 2025.
126 Little J, Shipley S, Rock M, Berger JR, Xu DJ: Paraneoplastic Tumefactive Demyelination with Anti-LUZP4 Antibody Associated with Metastatic Seminoma: A Case Report. American Academy of Neurology, San Diego, CA April 2025.
1c8 Shaik NF, Denison L, Venezia GMA, Ljungberg L, Lebrón-Cruz A, Resnick D, Peachey C, Ziemba C, Buckley M, Karamardian M, Liu PZ, Napole A, Hong J, Zeng R, Yu C, Chan A, Bae C, Stein L, Ellis CA, Xu DJ: Improving sleep on the inpatient general, non-stroke neurology service: a quasi-experimental interventional trial Journal of Hospital Medicine 2025 Notes: Accepted for publication.
12c Eisinger RS, Jones FJ, Pai EL, Xu D, Berger JR, Prasad S: Ideomotor Apraxia and 'Milky Way' Sign in Progressive Multifocal Leukoencephalopathy. Neurology 103(10): e209938, November 2024 Notes: DOI: 10.1212/WNL.0000000000209938.
146 Karamardian M, Stein L, Resnick D, Chambers C, Peachey C, Malinovitch A, Rosin R, Bae C, Buckley M, Xu DJ: Restoring Sleep for Neurology Inpatients. American Academy of Neurology, Denver, CO April 2024 Notes: Platform presentation and accepted abstract.
14e Lebron-Cruz A, Liu P, Venezia G, Ljungberg L, Peachey C, Buckley M, Karamardian M, Xu DJ, Bae C, Stein L, Ellis C: Characterizing Inpatient Sleep on the Neurology Service. American Academy of Neurology, Denver, CO April 2024 Notes: Poster and accepted abstract.
bb Douglas AG, Xu DJ, Shah MP: Approach to Myelopathy and Myelitis. Neurologic Clinics 40(1): 133-156, February 2022.
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