Thomas Francis Tropea, DO, MPH, MSTR
Philadelphia, PA 19107
Tufts University, 2005.
DO (Osteopathic Medicine)
University of New England College of Osteopathic Medicine, 2011.
MPH (Public Health)
University of New England, 2011.
MSTR (Translational Research)
University of Pennsylvania, 2018.
Medicine, Weill Cornell Medical College/NY Presbyterian Hospital, 2011-2012.
Neurology, Weill Cornell Medical College/NY Presbyterian Hospital, 2012-2015.
Movement Disorders and Translational Research, University of Pennsylvania Perelman School of Medicine, 2015-2018.
NeuroNEXT Fellow, University of Pennsylvania and NINDS, 2018-2019.
American Board of Psychiatric and Neurology, 2015.
Selected PublicationsTropea TF, Mak J, Guo MH, Xie SX, Suh E, Rick J, Siderowf A, Weintraub D, Grossman M, Irwin D, Wolk DA, Trojanowski JQ, Van Deerlin V, Chen-Plotkin AS.: TMEM106B Effect on Cognition in Parkinson's Disease and Frontotemporal Dementia. Annals of Neurology April 2019.
Tropea Thomas F, Xie Sharon X, Rick Jacqueline, Chahine Lana M, Dahodwala Nabila, Doshi Jimit, Davatzikos Christos, Shaw Leslie M, Van Deerlin Vivianna, Trojanowski John Q, Weintraub Daniel, Chen-Plotkin Alice S: APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 33(2): 289-297, Feb 2018.
Tropea Thomas F, Chen-Plotkin Alice S: Unlocking the mystery of biomarkers: A brief introduction, challenges and opportunities in Parkinson Disease. Parkinsonism & related disorders 46 Suppl 1: S15-S18, Jan 2018.
Martínez-Rivera A, Hao J, Tropea T F, Giordano T P, Kosovsky M, Rice R C, Lee A, Huganir R L, Striessnig J, Addy N A, Han S, Rajadhyaksha A M: Enhancing VTA Ca1.3 L-type Ca channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular psychiatry 22(12): 1735-1745, Dec 2017.
Schierberl Kathryn, Hao Jin, Tropea Thomas F, Ra Stephen, Giordano Thomas P, Xu Qinghao, Garraway Sandra M, Hofmann Franz, Moosmang Sven, Striessnig Joerg, Inturrisi Charles E, Rajadhyaksha Anjali M: Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(38): 13562-75, Sep 2011.
Ren Jia-Qian, Jiang Yan, Wang Zhihui, McCarthy Deirdre, Rajadhyaksha Anjali M, Tropea Thomas F, Kosofsky Barry E, Bhide Pradeep G: Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacology 60(2-3): 295-302, Feb-Mar 2011.
Tropea Thomas F, Kabir Zeeba D, Kaur Gagandeep, Rajadhyaksha Anjali M, Kosofsky Barry E: Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry 2: 67, 2011.
Giordano Thomas P, Tropea Thomas F, Satpute Shirish S, Sinnegger-Brauns Martina J, Striessnig Joerg, Kosofsky Barry E, Rajadhyaksha Anjali M: Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience 30(50): 17051-62, Dec 2010.
Gregus Ann M, Tropea Thomas F, Wang Yanran, Hauck Stefanie C R, Costa Alberto C S, Rajadhyaksha Anjali M, Inturrisi Charles E: Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. Neuroscience letters 468(3): 186-9, Jan 2010.
Tropea Thomas F, Kosofsky Barry E, Rajadhyaksha Anjali M: Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry 106(4): 1780-90, Aug 2008.